Multiple myeloma

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About the authors

Larisa P. Mendeleeva

National Research Center for Hematology

Author for correspondence.
Email: or@hpmp.ru
ORCID iD: 0000-0002-4966-8146

D. Sci. (Med.)

Russian Federation, Moscow

Olga M. Votiakova

Blokhin National Medical Research Center of Oncology

Email: or@hpmp.ru

Cand. Sci. (Med.), Blokhin National Medical Research Center of Oncology

Russian Federation, Moscow

Irina G. Rekhtina

National Research Center for Hematology

Email: or@hpmp.ru

D. Sci. (Med.), National Research Center for Hematology

Russian Federation, Moscow

Evgenii A. Osmanov

Blokhin National Medical Research Center of Oncology; Sechenov First Moscow State Medical University (Sechenov University)

Email: or@hpmp.ru

D. Sci. (Med.), Prof., Blokhin National Medical Research Center of Oncology, Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Irina V. Poddubnaya

Russian Medical Academy of Continuous Professional Education

Email: or@hpmp.ru
ORCID iD: 0000-0002-0995-1801

D. Sci. (Med.), Prof., Acad. RAS, Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow

Liudmila Iu. Grivtsova

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Email: or@hpmp.ru

Cand. Sci. (Med.), D. Sci. (Biol.), Tsyba Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Russian Federation, Obninsk

Natalia A. Falaleeva

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Email: or@hpmp.ru

D. Sci. (Med.), Tsyba Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Russian Federation, Obninsk

Vadim V. Baikov

Pavlov First Saint Petersburg State Medical University

Email: or@hpmp.ru

D. Sci. (Med.), Prof., Pavlov First Saint Petersburg State Medical University

Russian Federation, Saint Petersburg

Alla M. Kovrigina

National Research Center for Hematology; Academy of Postgraduate Education

Email: or@hpmp.ru

D. Sci. (Biol.), Prof., Academy of Postgraduate Education, National Research Center for Hematology

Russian Federation, Moscow

Aleksei A. Nevol’skikh

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Email: or@hpmp.ru

D. Sci. (Med.), Tsyba Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Russian Federation, Obninsk

Sergei A. Ivanov

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Email: or@hpmp.ru

D. Sci. (Med.), Prof. RAS, Tsyba Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Russian Federation, Obninsk

Zhanna V. Khailova

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Email: or@hpmp.ru

Cand. Sci. (Med.), Tsyba Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

Russian Federation, Obninsk

Tigran G. Gevorkian

Blokhin National Medical Research Center of Oncology

Email: or@hpmp.ru

deputy director, Blokhin National Medical Research Center of Oncology

Russian Federation, Moscow

References

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  81. Lewis EB. Leukemia, Multiple Myeloma, and Aplastic Anemia in American Radiologists. Science (80-.) 1963; 142 (3598): 1492–4.
  82. Linet MS, Harlow SD, McLaughlin JK. A case-control study of multiple myeloma in whites: chronic antigenic stimulation, occupation, and drug use. Cancer Res. 1987; 47 (11): 2978–81.
  83. Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 1998; 91 (1): 3–21.
  84. Kuehl WM, Bergsagel PL. Molecular pathogenesis of multiple myeloma and its premalignant precursor. J Clin Invest 2012; 122 (10): 3456–63.
  85. Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer 2012; 12 (5): 335–48.
  86. Fonseca R et al. International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review. Leukemia 2009; 23 (12): 2210–21.
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  89. Durie BGM, Salmon SE. A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975; 36 (3): 842–54.
  90. Greipp PR et al. International staging system for multiple myeloma. J Clin Oncol 2005; 23 (15): 3412–20.
  91. Palumbo A et al. Revised international staging system for multiple myeloma: A report from international myeloma working group. J Clin Oncol Am Soc Clin Oncol 2015; 33 (26): 2863–9.
  92. Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 2009; 23 (1): 3–9.
  93. Moreau P et al. Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol 2017; 28 (Suppl. 4): iv52–iv61.
  94. Rajkumar SV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 2014; 15 (12): e538–e548.
  95. Coppola A et al. Bleeding and thrombosis in multiple myeloma and related plasma cell disorders. Semin Thromb Hemost 2011; 37 (8): 929–45.
  96. Tripathy S. The role of serum protein electrophoresis in the detection of multiple myeloma: An experience of a corporate hospital. J Clin Diagnostic Res 2012; 6 (9): 1458–61.
  97. Misra A et al. Old but Still Relevant: High Resolution Electrophoresis and Immunofixation in Multiple Myeloma. Ind J Hematol Blood Transfusion 2016; 32 (1): 10–7.
  98. Любимова Н.В. и др. Свободные легкие цепи иммуноглобулинов в диагностике и прогнозе множественной миеломы. Альманах клин. медицины. 2017; 45 (2): 102–8. [Liubimova N.V. et al. Svobodnye legkie tsepi immunoglobulinov v diagnostike i prognoze mnozhestvennoi mielomy. Al’manakh klin. meditsiny. 2017; 45 (2): 102–8 (in Russian).]
  99. Pratt G, Goodyear O, Moss P. Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol 2007; 138 (5): 563–79.
  100. Julie D et al. Comparison of Bone marrow Aspirate and Bone marrow Biopsy in the workup of Patients with Multiple Myeloma. Clin Lymphoma Myeloma Leuk 2015; 15: e117.
  101. Pianko MJ et al. Whole-body low-dose computed tomography and advanced imaging techniques for multiple myeloma bone disease. Clinl Cancer Res 2014; 20 (23): 5888–97.
  102. Cavo M et al. Role of 18F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group. Lancet Oncol 2017; 18 (4): e206–e217.
  103. Mateos M-V, San Miguel J. V. Smoldering multiple myeloma. Hematol Oncol 2015; 33: 33–7.
  104. Zou Y et al. Bortezomib and lenalidomide as front-line therapy for multiple myeloma. Leuk Lymphoma 2014; 55 (9): 2024–31.
  105. Mateos MV et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III VISTA trial. J Clin Oncol 2010; 28 (13): 2259–66.
  106. Bringhen S et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood 2010; 116 (23): 4745–53.
  107. Takezako N et al. The Efficacy and Safety of Weekly Bortezomib Containing VMP Followed By Bortezomib Maintenance Therapy in Unfit or Frail Multiple Myeloma Patients. Blood 2016; 128 (22).
  108. Jagannath S et al. Extended follow-up of a phase 2 trial of bortezomib alone and in combination with dexamethasone for the frontline treatment of multiple myeloma. Br J Haematol 2009; 146 (6): 619–26.
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2. The induction therapy algorithm

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3. Treatment algorithm for the relapse of multiple myeloma

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