Final data on the efficacy of the FORA study (FOrteca Real practice Assessment): a multicenter prospective observational study on the real-world efficacy of prolgolimab in patients with metastatic melanoma in Russia
- Authors: Orlova K.V.1, Fedyanin M.I.1,2,3, Simanenkov K.E.4, Dergunov A.S.5, Goldshmidt P.R.4, Saydullaeva A.F.5, Bogacheva D.V.6, Yavorskaya M.A.7, Azanov A.Z.8, Fedenko A.A.9, Bolotina L.V.9, Deshkina T.I.9, Babina K.G.10, Kuzevanova E.A.11, Zhukova L.G.12, Feoktistova P.S.12, Polshina N.I.12, Peganova E.V.13, Shikina V.E.14, Sobolev M.M.15, Mironov O.V.16, Vaschenko V.A.17, Ershova M.M.18, Mezhueva A.O.2, Orlova S.A.19, Tantsyrev D.A.20, Taskina D.K.21, Teterich A.A.22, Karabina E.V.23, Kostalanova Y.V.24, Bogacheva M.V.25, Zhukova N.V.26,27, Orlova R.V.27, Zinkevich M.V.28, Kazmin A.I.6, Volkonskiy M.V.29, Voronkova L.M.30, Karpova A.S.31, Maleyko M.L.32, Gorshenina M.N.33, Kryuchkova E.I.34, Moiseenko F.V.35, Murzina Y.I.36, Musin S.I.37, Ogloblin A.N.38, Perminova M.S.8, Dumbrava R.A.39, Emelyanov S.A.40, Protsenko S.A.41, Sultanbaev A.V.37, Tarasova A.V.24, Shakhnovich E.B.42, Demchenkova M.V.43, Lozovskaya Y.A.44, Musaeva K.S.45, Pavlova E.M.46, Skotnikov R.A.23, Chernova V.V.47, Chichkanova A.S.48, Akhmatova A.M.49, Zafirova M.A.18, Mischenko A.A.39, Ovsienko E.N.40, Petrukhnenko V.A.50, Syusyukaylova O.A.51, Tyugina Y.A.52, Shumilkina E.A.19, Stroyakovskiy D.L.29, Yurchenkov A.N.29, Baldin P.L.53, Belova A.S.54, Diduk O.V.55, Konovalova E.A.56, Lebedeva L.N.57, Li Y.A.58, Mashtapa V.V.44, Mironenkova Y.A.46, Narovenkova K.V.59, Pavlikova O.A.33, Parsadanova E.L.60, Pimonova I.S.61, Ruzhnikova A.A.57, Sivunova I.D.62, Soloveva E.P.57, Sosnin M.I.63, Temirsultanova K.T.45, Tyulegenova M.Z.64, Khodkevich A.V.59, Shakurova N.R.65, Efendieva S.N.66, Avagimyan K.L.44, Anokhina E.Р.67, Antoshkina M.I.33, Borzyanitsa S.M.8, Dzhentemirov S.K.68, Dmitrochenko M.V.34, Zheleznyak A.V.48, Komoza Y.V.59, Kopanev A.S.69, Kornienko T.I.16, Krasilnikova M.A.8, Lukhmanova D.A.67, Mazur N.S.18, Markina P.M.48, Mitapov Z.S.70, Osodoeva S.N.70, Prokopenko I.A.44, Radyukova I.M.71, Ramazanova M.S.69, Safarova A.R.72, Safronova M.A.34, Khabrieva K.M.73, Tsygankova N.S.34, Chermakova K.V.44, Chirkova T.A.74, Samoylenko I.V.1, Nazarova V.V.1, Akhmetyanova A.E.1, Demidov L.V.1
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Affiliations:
- Blokhin National Medical Research Center of Oncology
- Moscow Multidisciplinary Clinical Center “Kommunarka”
- Pirogov National Medical and Surgical Center
- Lipetsk Regional Oncological Dispensary
- Tver Regional Clinical Oncological Dispensary
- Voronezh Regional Clinical Oncology Dispensary
- Oncological Dispensary No. 2
- Rappoport Kuzbass Clinical Oncological Dispensary
- Hertsen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Centre
- Volgograd Regional Clinical Oncological Dispensary
- Regional Clinical Oncological Dispensary, Saratov
- Loginov Moscow Clinical Scientific Center
- Clinical Oncology Hospital
- Vladimirsky Moscow Regional Research Clinical Institute
- Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare
- Tambov Regional Oncological Clinical Dispensary
- Kostroma Oncological Dispensary
- Sverdlovsk Regional Oncological Dispensary
- Republican Clinical Oncological Dispensary
- Altai Regional Oncological Dispensary
- Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
- Belgorod Regional Oncological Dispensary
- Tula Regional Clinical Oncological Dispensary
- Samara Regional Clinical Oncology Dispensary
- Vologda Regional Clinical Hospital No. 2
- Saint Petersburg State University
- City Clinical Oncology Dispensary
- Leningrad Regional Clinical Oncology Dispensary
- Moscow City Oncological Hospital No. 62
- Republican Oncological Dispensary, Vladikavkaz
- Trans-Baikal Regional Oncological Dispensary
- Oncological Dispensary, Shakhty
- Republican Oncological Dispensary
- Smolensk Regional Oncological Clinical Dispensary
- Saint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology)
- Oncological Dispensary, Birobidzhan
- Republican Clinical Oncology Center
- Oryol Oncological Dispensary
- Primorsky Regional Oncological Dispensary
- Primushko Republican Clinical Oncological Dispensary
- Petrov National Medical Research Center of Oncology
- Korolyov City Hospital
- Irkutsk Regional Oncological Dispensary
- Ostroverkhov Kursk Cancer Research and Clinical Center
- Oncology Center “AiMed”
- Vologda Regional Oncological Dispensary
- 8Regional Clinical Oncological Dispensary, Ryazan
- Nizhny Novgorod Regional Clinical Oncology Center
- Oncological Dispensary, Nalchik
- Oncological Dispensary, Komsomolsk-on-Amur
- Ashkhamaf Adyghe Republican Clinical Oncology Center
- Ivanovo Regional Oncological Dispensary
- Naberezhnye Chelny Oncological Dispensary - branch of the Republican Clinical Oncological Dispensary
- Novgorod Regional Clinical Oncological Dispensary
- Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
- Murmansk Regional Oncological Dispensary
- Arkhangelsk Clinical Oncology Dispensary
- Clinic Lyadov
- Bryansk Regional Oncological Dispensary
- Sakhalin Regional Oncological Dispensary
- Tsyb Medical Radiological Research Center - branch of the National Medical Research Radiological Center
- Kamchatka Regional Oncology Center
- Krasnogorsk City Hospital No. 1
- Orenburg Regional Clinical Oncology Dispensary
- Tomsk Regional Oncological Dispensary
- Republican Cancer Center
- Regional Clinical Oncology Dispensary, Ulyanovsk
- Stavropol Regional Clinical Oncology Center
- Center of Oncology and Medical Radiology
- Buryat Republican Clinical Oncological Dispensary
- Clinical Oncological Dispensary
- Almetyevsk branch of the Republican Clinical Oncological Dispensary
- Republican Oncological Dispensary, Nazran
- Rappoport Novokuznetsk branch of the Kuzbass Clinical Oncological Dispensary
- Issue: Vol 26, No 1 (2024)
- Pages: 20-34
- Section: Articles
- URL: https://journals.rcsi.science/1815-1434/article/view/258570
- DOI: https://doi.org/10.26442/18151434.2024.1.202617
- ID: 258570
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Full Text
Abstract
Background. Prior to the introduction of new agents — immune checkpoint inhibitors — for inoperable and/or metastatic melanoma (IMM), chemotherapy outcomes were generally poor. The median (Me) overall survival (OS) in IMM was no more than 6-9 months, and the Me of progression-free survival (PFS) was about 2 months. The introduction of immune checkpoint inhibitors and targeted therapy changed the prognosis for the life of IMM patients dramatically. The development, studies, and approval of a new original PD-1 inhibitor, prolgolimab, in Russia in 2020 prompted the professional community to conduct a prospective observational study in the Russian Federation to assess its real-world efficacy and safety.
Aim To evaluate the real-world efficacy and safety of prolgolimab in patients with IMM.
Materials and methods. From October 2020 to October 2022, 700 patients with IMM receiving prolgolimab in real clinical settings in oncological institutions of various levels in the Russian Federation were included in the study. The main inclusion criteria were: pathology-confirmed diagnosis of melanoma; metastatic and/or inoperable type; use of prolgolimab outside of clinical trials; and signed informed consent. Objective response rate in the general population and the Intention-to-treat and Per Protocol populations was considered the main criterion for evaluating the efficacy of therapy, and the safety criterion was the incidence of grade 3-4 adverse events (AEs). PFS and OS rates were also assessed. Statistical analysis was performed using the SPSS 25.0 software package.
Results. The objective response rate for the Per Protocol population (with radiographic assessment available) was 42% (n=235/559). Disease progression was reported in 26.7% (n=149) of patients, stabilization in 31.3% (n=175), and disease control in 73.3% of patients with IMM, regardless of the line of therapy. At the follow-up Me of 12 months (0-36), PFS for all patients regardless of the line of therapy was 8 months (95% confidence interval [Cl] 6.537-9.463), 6-month PFS was 55%, and 12-month PFS was 41%. OS Me for all included patients was 32 months, 6-month OS was 82%, and 12-month OS was 69%. Depending on the line of therapy, the OS Me was: line 1 - not reached, line 2-30 months (95% Cl 16.007-43.993), line 3 and subsequent- 22 months (95% Cl 14.264-29.736); p=0.736. According to the CTCAE 5.0 general terminology criteria for AEs, a total of 136/693 (19.6%) AEs of varying degrees were reported, in particular: grade 1-2 - 105/693 (15.2%), grade 3-4 - 25/693 (3.6%), unknown grade - 5/693 (0.7%), as well as one fatal case (0.1%) due to thromboembolism in the vascular center with an unclear (according to the investigator's assessment) relation with prolgolimab.
Conclusion The results obtained at 12 months of follow-up confirm the high efficacy and satisfactory tolerability of prolgolimab in patients with IMM in real-world practice, regardless of the line of therapy and other characteristics.
Full Text
##article.viewOnOriginalSite##About the authors
Kristina V. Orlova
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0002-0442-5917
Cand. Sci. (Med.)
Russian Federation, MoscowMikhail Iu. Fedyanin
Blokhin National Medical Research Center of Oncology; Moscow Multidisciplinary Clinical Center “Kommunarka”; Pirogov National Medical and Surgical Center
Email: fedianinmu@mail.ru
ORCID iD: 0000-0001-5615-7806
SPIN-code: 4381-5628
D. Sci. (Med.)
Russian Federation, Moscow; Moscow; MoscowKonstantin E. Simanenkov
Lipetsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Department Head, Oncologist
Russian Federation, LipetskAleksandr S. Dergunov
Tver Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, TverPetr R. Goldshmidt
Lipetsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Deputy Chief doctor, Oncological Dispensary
Russian Federation, LipetskAleksandra F. Saydullaeva
Tver Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, TverDarya V. Bogacheva
Voronezh Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, VoronezhMarina A. Yavorskaya
Oncological Dispensary No. 2
Email: krisman03@gmail.com
Deputy Chief Doctor, Oncologist
Russian Federation, SochiArtur Z. Azanov
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, KemerovoAlexander A. Fedenko
Hertsen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Centre
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4927-5585
D. Sci. (Med.)
Russian Federation, MoscowLarisa V. Bolotina
Hertsen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Centre
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4879-2687
D. Sci. (Med.)
Russian Federation, MoscowTatyana I. Deshkina
Hertsen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Centre
Email: krisman03@gmail.com
Cand. Sci. (Med.), Oncologist
Russian Federation, MoscowKseniya G. Babina
Volgograd Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head chemotherapy
Russian Federation, VolgogradEkaterina A. Kuzevanova
Regional Clinical Oncological Dispensary, Saratov
Email: krisman03@gmail.com
Department Head, Regional Clinical Oncological Dispensary
Russian Federation, SaratovLiudmila G. Zhukova
Loginov Moscow Clinical Scientific Center
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4848-6938
D, Sci, (Med,), Corr, Memb. RAS
Russian Federation, MoscowPolina S. Feoktistova
Loginov Moscow Clinical Scientific Center
Email: krisman03@gmail.com
ORCID iD: 0000-0002-0340-7119
Cand, Sci, (Med,)
Russian Federation, MoscowNatalya I. Polshina
Loginov Moscow Clinical Scientific Center
Email: krisman03@gmail.com
ORCID iD: 0000-0001-5417-0425
Oncologist
Russian Federation, MoscowEkaterina V. Peganova
Clinical Oncology Hospital
Email: krisman03@gmail.com
Oncologist
Russian Federation, YaroslavlValentina E. Shikina
Vladimirsky Moscow Regional Research Clinical Institute
Email: krisman03@gmail.com
Cand, Sci, (Med,)
Russian Federation, MoscowMaksim M. Sobolev
Moscow City Oncological Hospital No. 1 of the Moscow Department of Healthcare
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, MoscowOleg V. Mironov
Tambov Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, TambovVera A. Vaschenko
Kostroma Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, KostromaMariya M. Ershova
Sverdlovsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, EkaterinburgAgniya O. Mezhueva
Moscow Multidisciplinary Clinical Center “Kommunarka”
Email: krisman03@gmail.com
Department Head, oncologist
Russian Federation, MoscowSvetlana A. Orlova
Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, CheboksaryDenis A. Tantsyrev
Altai Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
Russian Federation, BarnaulDarya K. Taskina
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Email: krisman03@gmail.com
Oncologist
Russian Federation, ChelyabinskAntonina A. Teterich
Belgorod Regional Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, BelgorodElena V. Karabina
Tula Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, TulaYuliya V. Kostalanova
Samara Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
Russian Federation, SamaraMarina V. Bogacheva
Vologda Regional Clinical Hospital No. 2
Email: krisman03@gmail.com
Oncologist
Russian Federation, VologdaNatalia V. Zhukova
Saint Petersburg State University; City Clinical Oncology Dispensary
Email: krisman03@gmail.com
ORCID iD: 0000-0002-0619-2205
Cand. Sci. (Med.)
Russian Federation, Saint Petersburg; Saint PetersburgRashida V. Orlova
City Clinical Oncology Dispensary
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4447-9458
D. Sci. (Med.), Prof.
Russian Federation, Saint PetersburgMaksim V. Zinkevich
Leningrad Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
Russian Federation, Saint PetersburgAleksandr I. Kazmin
Voronezh Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
Russian Federation, VoronezhMikhail V. Volkonskiy
Moscow City Oncological Hospital No. 62
Email: krisman03@gmail.com
ORCID iD: 0000-0003-4060-5015
Head of the Day Hospital
Russian Federation, MoscowLiya M. Voronkova
Republican Oncological Dispensary, Vladikavkaz
Email: krisman03@gmail.com
Department Head
Russian Federation, VladikavkazAnastasiya S. Karpova
Trans-Baikal Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, ChitaMikhail L. Maleyko
Oncological Dispensary, Shakhty
Email: krisman03@gmail.com
Cand. Sci. (Med.)
Russian Federation, ShakhtyMariya N. Gorshenina
Republican Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, Yoshkar-OlaElena I. Kryuchkova
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, SmolenskFedor V. Moiseenko
Saint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology)
Email: krisman03@gmail.com
ORCID iD: 0000-0003-2544-9042
D. Sci. (Med.)
Russian Federation, Saint Petersburg
Yuliya I. Murzina
Oncological Dispensary, Birobidzhan
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, BirobidzhanShamil I. Musin
Republican Clinical Oncology Center
Email: krisman03@gmail.com
Department Head
Russian Federation, UfaAndrey N. Ogloblin
Oryol Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, OryolMariya S. Perminova
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, KemerovoRegina A. Dumbrava
Primorsky Regional Oncological Dispensary
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, VladivostokSergey A. Emelyanov
Primushko Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, IzhevskSvetlana A. Protsenko
Petrov National Medical Research Center of Oncology
Email: krisman03@gmail.com
Department Head
Russian Federation, Saint PetersburgAlexander V. Sultanbaev
Republican Clinical Oncology Center
Email: krisman03@gmail.com
ORCID iD: 0000-0003-0996-5995
Cand. Sci. (Med.)
Russian Federation, UfaAnna V. Tarasova
Samara Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, SamaraElena B. Shakhnovich
Korolyov City Hospital
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, KorolyovMarina V. Demchenkova
Irkutsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, IrkutskYuliya A. Lozovskaya
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
Russian Federation, KurskKhedi S. Musaeva
Oncology Center “AiMed”
Email: krisman03@gmail.com
Department Head
Russian Federation, GroznyElena M. Pavlova
Vologda Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
Russian Federation, VologdaRoman A. Skotnikov
Tula Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, TulaVera V. Chernova
8Regional Clinical Oncological Dispensary, Ryazan
Email: krisman03@gmail.com
Oncologist
Russian Federation, RyazanAngelina S. Chichkanova
Nizhny Novgorod Regional Clinical Oncology Center
Email: krisman03@gmail.com
Head of the Day Hospital
Russian Federation, Nizhny NovgorodAdina M. Akhmatova
Oncological Dispensary, Nalchik
Email: krisman03@gmail.com
Oncologist, Oncological Dispensary
Russian Federation, NalchikMarina A. Zafirova
Sverdlovsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of Chemotherapy Service
Russian Federation, EkaterinburgAndrey A. Mischenko
Primorsky Regional Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital, Primorsky Regional Oncological Dispensary
Russian Federation, VladivostokElena N. Ovsienko
Primushko Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, IzhevskViktoriya A. Petrukhnenko
Oncological Dispensary, Komsomolsk-on-Amur
Email: krisman03@gmail.com
Department Head
Russian Federation, Komsomolsk-on-AmurOksana A. Syusyukaylova
Ashkhamaf Adyghe Republican Clinical Oncology Center
Email: krisman03@gmail.com
Department Head
Russian Federation, MaykopYana A. Tyugina
Ivanovo Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, Ivanovo
Elena A. Shumilkina
Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, CheboksaryDaniil L. Stroyakovskiy
Moscow City Oncological Hospital No. 62
Email: krisman03@gmail.com
ORCID iD: 0000-0003-1973-1092
Cand. Sci. (Med.)
Russian Federation, MoscowAleksandr N. Yurchenkov
Moscow City Oncological Hospital No. 62
Email: krisman03@gmail.com
Cand. Sci. (Med.)
Russian Federation, MoscowPavel L. Baldin
Naberezhnye Chelny Oncological Dispensary - branch of the Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, Naberezhnye ChelnyAnastasiya S. Belova
Novgorod Regional Clinical Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, Veliky NovgorodOlga V. Diduk
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, KrasnoyarskElena A. Konovalova
Murmansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, MurmanskLyudmila N. Lebedeva
Arkhangelsk Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, ArkhangelskYaroslav A. Li
Clinic Lyadov
Email: krisman03@gmail.com
Oncologist
Russian Federation, KhimkiViktoriya V. Mashtapa
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
Russian Federation, KurskYana A. Mironenkova
Vologda Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, VologdaKristina V. Narovenkova
Bryansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, BryanskOlga A. Pavlikova
Republican Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, Yoshkar-OlaElvira L. Parsadanova
Sakhalin Regional Oncological Dispensary
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, Yuzhno-SakhalinskIrina S. Pimonova
Tsyb Medical Radiological Research Center - branch of the National Medical Research Radiological Center
Email: krisman03@gmail.com
Oncologist
Russian Federation, ObninskAnna A. Ruzhnikova
Arkhangelsk Clinical Oncology Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, ArkhangelskIrina D. Sivunova
Kamchatka Regional Oncology Center
Email: krisman03@gmail.com
Department Head
Russian Federation, Petropavlovsk-KamchatskyEkaterina P. Soloveva
Arkhangelsk Clinical Oncology Dispensary
Email: krisman03@gmail.com
Cand. Sci. (Med.)
Russian Federation, ArkhangelskMaksim I. Sosnin
Krasnogorsk City Hospital No. 1
Email: krisman03@gmail.com
Oncologist
Russian Federation, KrasnogorskKh. Toita Temirsultanova
Oncology Center “AiMed”
Email: krisman03@gmail.com
Department Head
Russian Federation, GroznyMakhabbat Zh. Tyulegenova
Orenburg Regional Clinical Oncology Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
Russian Federation, OrenburgAleksandra V. Khodkevich
Bryansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, BryanskNadezhda R. Shakurova
Tomsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, TomskSureya N. Efendieva
Republican Cancer Center
Email: krisman03@gmail.com
Deputy Chief Doctor
Russian Federation, MakhachkalaKarine L. Avagimyan
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
Russian Federation, KurskEkaterina Р. Anokhina
Regional Clinical Oncology Dispensary, Ulyanovsk
Email: krisman03@gmail.com
Oncologist
Russian Federation, UlyanovskMariya I. Antoshkina
Republican Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, SaranskStanislav M. Borzyanitsa
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, KemerovoSamir K. Dzhentemirov
Stavropol Regional Clinical Oncology Center
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, StavropolMarina V. Dmitrochenko
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, SmolenskAlla V. Zheleznyak
Nizhny Novgorod Regional Clinical Oncology Center
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, Nizhny NovgorodYuliya V. Komoza
Bryansk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, BryanskAleksandr S. Kopanev
Center of Oncology and Medical Radiology
Email: krisman03@gmail.com
Oncologist
Russian Federation, KirovTatyana I. Kornienko
Tambov Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, TambovMargarita A. Krasilnikova
Rappoport Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Head of the Day Hospital
Russian Federation, KemerovoDarya A. Lukhmanova
Regional Clinical Oncology Dispensary, Ulyanovsk
Email: krisman03@gmail.com
Oncologist
Russian Federation, UlyanovskNatalya S. Mazur
Sverdlovsk Regional Oncological Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, EkaterinburgPolina M. Markina
Nizhny Novgorod Regional Clinical Oncology Center
Email: krisman03@gmail.com
Oncologist
Russian Federation, Nizhny NovgorodZhargal S. Mitapov
Buryat Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, Ulan-UdeSvetlana N. Osodoeva
Buryat Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, Ulan-UdeIrina A. Prokopenko
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Department Head
Russian Federation, KurskIrina M. Radyukova
Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, OmskMadina S. Ramazanova
Center of Oncology and Medical Radiology
Email: krisman03@gmail.com
Department Head
Russian Federation, KirovAlfiya R. Safarova
Almetyevsk branch of the Republican Clinical Oncological Dispensary
Email: krisman03@gmail.com
Chemotherapist
Russian Federation, AlmetyevskMariya A. Safronova
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, SmolenskKhalimat M. Khabrieva
Republican Oncological Dispensary, Nazran
Author for correspondence.
Email: krisman03@gmail.com
Oncologist
Russian Federation, NazranNatalya S. Tsygankova
Smolensk Regional Oncological Clinical Dispensary
Email: krisman03@gmail.com
Oncologist
Russian Federation, SmolenskKseniya V. Chermakova
Ostroverkhov Kursk Cancer Research and Clinical Center
Email: krisman03@gmail.com
Oncologist
Russian Federation, KurskTatyana A. Chirkova
Rappoport Novokuznetsk branch of the Kuzbass Clinical Oncological Dispensary
Email: krisman03@gmail.com
Department Head
Russian Federation, NovokuznetskIgor V. Samoylenko
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0001-7150-5071
Cand. Sci. (Med.)
Russian Federation, MoscowValeria V. Nazarova
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0003-0532-6061
Cand. Sci. (Med.)
Russian Federation, MoscowAngelina E. Akhmetyanova
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
Graduate Student
Russian Federation, MoscowLev V. Demidov
Blokhin National Medical Research Center of Oncology
Email: krisman03@gmail.com
ORCID iD: 0000-0002-8562-6082
D. Sci. (Med.), Prof.
Russian Federation, MoscowReferences
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