Opportunities of ICG-fluorescent imaging of lymph nodes during radical cystectomy in patients with bladder cancer: A review

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Abstract

Today, the "golden standard" for the treatment of aggressive forms of bladder cancer is radical cystectomy. An important stage is the pelvic lymphadenectomy. This procedure is crucial for staging the tumor process, determining the subsequent treatment tactics and improving the results of surgery. Currently, the concept of a signaling lymph node (LN) is actively developing, which allows reducing the necessary level of dissection of the pelvic LN. Reducing the number of resected LN increases the level of surgical safety of the patient. The leading method of intraoperative visualization of signal LN is the fluorescence of indocyanine green in the near infrared range of the spectrum. The prospects of this diagnostic method for radical cystectomy in patients with bladder cancer determine the vector of future scientific research in this area.

About the authors

Valentin N. Pavlov

Bashkir State Medical University

Email: pavlov@bashgmu.ru
ORCID iD: 0000-0003-2125-4897
SPIN-code: 2799-6268
Scopus Author ID: 666803

D. Sci. (Med.), Prof., Corr. Memb. RAS

Russian Federation, Ufa

Marat F. Urmantsev

Bashkir State Medical University

Author for correspondence.
Email: urmantsev85@mail.ru
ORCID iD: 0000-0002-4657-6625
SPIN-code: 3506-7753
Scopus Author ID: 889757

Cand. Sci. (Med.)

Russian Federation, Ufa

Marat R. Bakeev

Bashkir State Medical University

Email: m.r.bakeev@bk.ru
ORCID iD: 0000-0002-4160-2820

Student

Russian Federation, Ufa

References

  1. Witjes JA, Compérat E, Cowan NC, et al. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol. 2014;65(4):778-92.
  2. Mehlen P, Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer. 2006;6(6):449-58.
  3. Nguyen DX, Bos PD, Massagué J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009;9(4):274-84.
  4. Pini G, Matin SF, Suardi N, et al. Robot assisted lymphadenectomy in urology: pelvic, retroperitoneal and inguinal. Minerva Urol Nefrol. 2017;69(1):38-55.
  5. Polom W, Markuszewski M, Cytawa W, et al. Fluorescent Versus Radioguided Lymph Node Mapping in Bladder Cancer. Clin Genitourin Cancer. 2017;15(3):e405-9.
  6. Leissner J, Ghoneim MA, Abol-Enein H, et al. Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol. 2004;171(1):139-44.
  7. Inoue S, Shiina H, Mitsui Y, et al. Identification of lymphatic pathway involved in the spread of bladder cancer: Evidence obtained from fluorescence navigation with intraoperatively injected indocyanine green. Can Urol Assoc J. 2013;7(5-6):E322-8.
  8. Polom K, Murawa D, Rho YS, et al. Current trends and emerging future of indocyanine green usage in surgery and oncology: a literature review. Cancer. 2011;117(21):4812-22.
  9. Xiong L, Gazyakan E, Yang W, et al. Indocyanine green fluorescence-guided sentinel node biopsy: a meta-analysis on detection rate and diagnostic performance. Eur J Surg Oncol. 2014;40(7):843-9.
  10. Абоян И.А., Пакус Д.И., Пакус С.М., и др. Робот-ассистированная тазовая лимфаденэктомия с использованием ICG-диагностики у пациентов с раком предстательной железы. Онкоурология 2018;14(3):51-7 [Aboyan IA, Pakus DI, Pakus SM, et al. Robot-assisted pelvic lymph node dissection using ICG testing in patients with prostate cancer. Onkourologiya = Cancer Urology. 2018;14(3):51-7 (in Russian)].
  11. Imboden S, Papadia A, Nauwerk M, et al. A Comparison of Radiocolloid and Indocyanine Green Fluorescence Imaging, Sentinel Lymph Node Mapping in Patients with Cervical Cancer Undergoing Laparoscopic Surgery. Ann Surg Oncol. 2015;22(13):4198-203.
  12. Papadia A, Imboden S, Siegenthaler F, et al. Laparoscopic Indocyanine Green Sentinel Lymph Node Mapping in Endometrial Cancer. Ann Surg Oncol. 2016;23(7):2206-11.
  13. Hachey KJ, Gilmore DM, Armstrong KW, et al. Safety and feasibility of near-infrared image-guided lymphatic mapping of regional lymph nodes in esophageal cancer. J Thorac Cardiovasc Surg. 2016;152(2):546-54.
  14. Kinami S, Oonishi T, Fujita J, et al. Optimal settings and accuracy of indocyanine green fluorescence imaging for sentinel node biopsy in early gastric cancer. Oncol Lett. 2016;11(6):4055-2.
  15. Currie AC, Brigic A, Thomas-Gibson S, et al. A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer. Eur J Surg Oncol. 2017;43(11):2044-51.
  16. Pathak RA, Hemal AK. Intraoperative ICG-fluorescence imaging for robotic-assisted urologic surgery: current status and review of literature. Int Urol Nephrol. 2019;51(5):765-71.
  17. Schaafsma BE, Mieog JS, Hutteman M, et al. The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. J Surg Oncol. 2011;104(3):323-32.
  18. Schols RM, Bouvy ND, van Dam RM, Stassen LP. Advanced intraoperative imaging methods for laparoscopic anatomy navigation: an overview. Surg Endosc. 2013;27(6):1851-9.
  19. Chennamsetty A, Zhumkhawala A, Tobis SB, et al. Lymph node fluorescence during robot-assisted radical prostatectomy with indocyanine green: prospective dosing analysis. Clin Genitourin Cancer. 2017;15(4):e529-34.
  20. Buda A, Bussi B, Di Martino G, et al. Sentinel lymph node mapping with near-infrared fluorescent imaging using indocyanine green: a new tool for laparoscopic platform in patients with endometrial and cervical cancer. J Minim Invasive Gynecol. 2016;23(2):265-9.
  21. Buda A, Dell'Anna T, Vecchione F, et al. Near-infrared sentinel lymph node mapping with indocyanine green using the VITOM II ICG exoscope for open surgery for gynecologic malignancies. J Minim Invasive Gynecol. 2016;23(4):628-32.
  22. Buda A, Passoni P, Corrado G, et al. Near-infrared fluorescence-guided sentinel node mapping of the ovary with indocyanine green in a minimally invasive setting: a feasible study. J Minim Invasive Gynecol. 2017;24(1):165-70.
  23. van Manen L, Handgraaf HJM, Diana M, et al. A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery. J Surg Oncol. 2018;118(2):283-300.
  24. Ishizawa T, Masuda K, Urano Y, et al. Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma. Ann Surg Oncol. 2014;21(2):440-8.
  25. Aoki T, Yasuda D, Shimizu Y, et al. Image-guided liver mapping using fluorescence navigation system with indocyanine green for anatomical hepatic resection. World J Surg. 2008;32(8):1763-7.
  26. Boogerd LS, Handgraaf HJ, Lam HD, et al. Laparoscopic detection and resection of occult liver tumors of multiple cancer types using real-time near-infrared fluorescence guidance. Surg Endosc. 2017;31(2):952-61.
  27. Peloso A, Franchi E, Canepa MC, et al. Combined use of intraoperative ultrasound and indocyanine green fluorescence imaging to detect liver metastases from colorectal cancer. HPB (Oxford). 2013;15(12):928-34.
  28. Abo T, Nanashima A, Tobinaga S, et al. Usefulness of intraoperative diagnosis of hepatic tumors located at the liver surface and hepatic segmental visualization using indocyanine green-photodynamic eye imaging. Eur J Surg Oncol. 2015;41(2):257-64.
  29. DeLong JC, Chakedis JM, Hosseini A, et al. Indocyanine green (ICG) fluorescence-guided laparoscopic adrenalectomy. J Surg Oncol. 2015;112(6):650-3.
  30. Sound S, Okoh AK, Bucak E, et al. Intraoperative tumor localization and tissue distinction during robotic adrenalectomy using indocyanine green fluorescence imaging: a feasibility study. Surg Endosc. 2016;30(2):657-62.
  31. Manny TB, Pompeo AS, Hemal AK. Robotic partial adrenalectomy using indocyanine green dye with near-infrared imaging: the initial clinical experience. Urology. 2013;82(3):738-42.
  32. Dip F, Roy M, Lo Menzo E, et al. Routine use of fluorescent incisionless cholangiography as a new imaging modality during laparoscopic cholecystectomy. Surg Endosc. 2015;29(6):1621-6.
  33. Dip FD, Asbun D, Rosales-Velderrain A, et al. Cost analysis and effectiveness comparing the routine use of intraoperative fluorescent cholangiography with fluoroscopic cholangiogram in patients undergoing laparoscopic cholecystectomy. Surg Endosc. 2014;28(6):1838-43.
  34. Siddighi S, Yune JJ, Hardesty J. Indocyanine green for intraoperative localization of ureter. Am J Obstet Gynecol. 2014;211(4):436.e1-2.
  35. Lee Z, Moore B, Giusto L, Eun DD. Use of indocyanine green during robot-assisted ureteral reconstructions. Eur Urol. 2015;67(2):291-8.
  36. Kumagai Y, Ishiguro T, Haga N, et al. Hemodynamics of the reconstructed gastric tube during esophagectomy: assessment of outcomes with indocyanine green fluorescence. World J Surg. 2014;38(1):138-43.
  37. Koyanagi K, Ozawa S, Oguma J, et al. Blood flow speed of the gastric conduit assessed by indocyanine green fluorescence: new predictive evaluation of anastomotic leakage after esophagectomy. Medicine (Baltimore). 2016;95(30):e4386.
  38. Watanabe J, Ota M, Suwa Y, et al. Evaluation of the intestinal blood flow near the rectosigmoid junction using the indocyanine green fluorescence method in a colorectal cancer surgery. Int J Colorectal Dis. 2015;30(3):329-35.
  39. Kin C, Vo H, Welton L, Welton M. Equivocal effect of intraoperative fluorescence angiography on colorectal anastomotic leaks. Dis Colon Rectum. 2015;58(6):582-7.
  40. Inoue Y, Arita J, Sakamoto T, et al. Anatomical liver resections guided by 3-dimensional parenchymal staining using fusion indocyanine green fluorescence imaging. Ann Surg. 2015;262(1):105-11.
  41. Kawaguchi Y, Nomura Y, Nagai M, et al. Liver transection using indocyanine green fluorescence imaging and hepatic vein clamping. Br J Surg. 2017;104(7):898-906.
  42. Котов С.В., Простомолотов А.О. Симптоматические лимфатические кисты после онкоурологических операций на органах малого таза и влияние их анатомической локализации на клиническую картину. Вестник урологии. 2020;8(4):72-9 [Kotov SV, Prostomolotov AО. Symptomatic lymphatic cysts after oncourological operations on the pelvic organs and influence of their anatomical localization on the clinical appearance. Urology Herald. 2020;8(4):72-9 (in Russian)].
  43. Hurle R, Naspro R. Pelvic lymphadenectomy during radical cystectomy: a review of the literature. Surg Oncol. 2010;19(4):208-20.
  44. Schaafsma BE, Verbeek FP, Elzevier HW, et al. Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging. J Surg Oncol. 2014;110(7):845-50.
  45. Manny TB, Hemal AK. Fluorescence-enhanced robotic radical cystectomy using unconjugated indocyanine green for pelvic lymphangiography, tumor marking, and mesenteric angiography: the initial clinical experience. Urology. 2014;83(4):824-9.
  46. Patel MN, Hemal AK. Molecular Targeted Fluorescence-Guided Intraoperative Imaging of Bladder Cancer Nodal Drainage Using Indocyanine Green During Radical and Partial Cystectomy. Curr Urol Rep. 2016;17(10):74.

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