Email this article Ifosfamide/cyclofosfamide-induced methemoglobinemia in pediatric patients with hemoblastoses
- Authors: Valiev T.T.1,2, Korkina Y.S.1
-
Affiliations:
- Blokhin National Medical Research Center of Oncology
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 22, No 4 (2020)
- Pages: 139-142
- Section: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/61199
- DOI: https://doi.org/10.26442/18151434.2020.4.200481
- ID: 61199
Cite item
Full Text
Abstract
Rare side effects of already known chemotherapy drugs are a difficult case for clinician. In this article, there is a description of 15 cases of the development of methemoglobinemia after the use of ifosfamide and cyclophosphamide in the therapy of acute lymphoblastic leukemia and Burkitt lymphoma. And when ifosfamide-induced methemoglobinemia is already described in the world literature as a form of isolated cases, cyclophosphamide-induced one is presented for the first time in this article in our (domestic) clinical practice. Both pathophysiological basis and inducer drugs are described in the article in detail. Special attention is paid to hereditary variants of methemoglobinemia and to possible combinations of hereditary and drug-induced variants. Clinical and laboratory criteria for the methemoglobinemia diagnosis and corresponding treatment recommendations are provided by the authors.
Full Text
##article.viewOnOriginalSite##About the authors
Timur T. Valiev
Blokhin National Medical Research Center of Oncology; Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: timurvaliev@mail.ru
D. Sci. (Med.), Prof.
Russian Federation, MoscowYulia S. Korkina
Blokhin National Medical Research Center of Oncology
Email: timurvaliev@mail.ru
Medical Resident
Russian Federation, MoscowReferences
- Hadjiliadis D, Govert JA. Methemoglobinemia after infusion of ifosfamide chemotherapy: first report of a potentially serious adverse reaction related to ifosfamide. Chest 2000;118 (4): 1208–10.
- Shehadeh N, Dansey R, Seen S, Abella E. Cyclophosphamide-induced methemoglobinemia. Bone Marrow Transplant 2003; 32 (11): 1109–10.
- Атажанов Т.Б., Шведов К.С. Клинический случай метгемоглобинемии. Академическая наука – проблемы и достижения. 2019: 21–4. [Atazhanov T.B., Shvedov K.S. Clinical case of methemoglobinemia. Academic Science – Problems and Achievements. 2019: 21–4 (in Russian).]
- Куценко С.А. Военная токсикология, радиобиология и медицинская защита. СПб.: Фолиант, 2004. [Kutsenko S.A. Military toxicology, radiobiology and medical protection. Saint Petersburg: Foliant, 2004 (in Russian).]
- Берман Р.Э., Клигман Р.М., Дженсон Х.Б. Педиатрия по Нельсону. Т. 4. М.: Рид Элсивер; 2009. [Berman R.E., Kligman R.M., Jenson Kh.B. Nelson Textbook of Pediatrics. Vol. 4. Moscow: Rid Elsiver; 2009 (in Russian).]
- Клейменова И.С., Швырев А.П., Середняк В.Г. и др. Врожденная энзимопеническая метгемоглобинемия II типа. Российский вестник перинатологии и педиатрии. 2011; 56 (6): 80–7. [Kleimenova I.S., Shvyrev A.P., Serednyak V.G. et al. Type II hereditary enzymopenic methemoglobinemia. Russian Bulletin of Perinatology and Pediatrics. 2011; 56 (6): 80–7 (in Russian).]
- Галеева Н.М., Клейменова И.С., Ненашева С.А. и др. Наследственная метгемоглобинемия I и II типов: описание трех случаев с молекулярно-генетической верификацией. Медицинская генетика. 2012; 11 (6): 39–45. [Galeeva N.M., Kleymenova I.S., Nenasheva S.A. et al. Recessive co genital methemoglobinemia type I and II: 3 case reports with molecular confir mation. Medical Genetics. 2012; 11 (6): 39–45 (in Russian).]
- Бахрамов С.М., Мардонов А.К., Ашрабходжаева К.К., Турабов А.З. Метгемоглобинемии. Дневник Казанской медицинской школы. 2015; 3: 56–62. [Bakhramov S.M., Mardonov A.K., Ashrabkhodzhaeva K.K., Turabov A.Z. Methemoglobinemias. Kazan Medical School Diary. 2015; 3: 56–62 (in Russian).]
- Алексеев Н.А. Гематология и иммунология детского возраста. СПб.: Гиппократ; 2009. [Alekseev N.A. Pediatric Hematology and Immunology. Saint Petersburg: Hippocrates; 2009 (in Russian).]
- Файнштейн Ф.Э., Козинец Г.И., Бахрамов С.М., Хохлова М.П. Болезни системы крови. Ташкент: Медицина, 1977. [Fainshtein F.E., Kozinets G.I., Bakhramov S.M., Khokhlova M.P. Diseases of the blood system. Tashkent: Medicine, 1977 (in Russian).]
- Галеева Н.М., Назаренко Л.П., Назаренко C.A. и др. Молекулярно-генетическая причина наследственной метгемоглобинемии первого типа в Якутии. Медицинская генетика. 2006; 5 (9): 15–21. [Galeeva N.M., Nazarenko L.P., Nazarenko C.A. et al. Molekuliarno-geneticheskaia prichina nasledstvennoi metgemoglobinemii pervogo tipa v Iakutii. Medical Genetics. 2006; 5 (9): 15–21 (in Russian).]
