Clinico-morphological predictors and treatment outcomes in cervical stump cancer


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Abstract

The aim of the study is to analyze the characteristics of cervical stump cancer (CSC), identify the clinical and morphological factors influencing prognosis of the disease. Another aim is to study the results of CSC treatment according to the predictive factors. Materials and methods. We have analyzed the treatment results of 150 patients with FIGO stage 0-IIIB metastatic CSC (mCSC). Patients were treated in N.N.Blokhin Russian Cancer Research Center, over the period from 1977 to 2010. Results. We showed that statistically significant predictive factors of mCSC were regional lymph node metastases, stromal invasion greater than 1 cm in depth, stage of disease, the mixed form of tumor growth and the presence of lymph vessel tumor emboli. We also identified that the survival of the patients with histologically verified adenocarcinoma and with the spread of the tumor to the cervical stump was poor. Conclusion. We showed that the risk factors in case of mCSC were the same as in case of cervical cancer.

About the authors

L Sh Usmanova

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

канд. мед. наук, ст. науч. сотр. отд-ния радиохирургии отд. радиационной онкологии ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

V V Kuznetsov

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., вед. науч. сотр. гинекологического отд-ния ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

E A Mustafina

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

Email: ekaterina.mustafina.78@mail.ru
канд. мед. наук, науч. сотр. гинекологического отд-ния ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

V V Barinov

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., вед. науч. сотр. гинекологического отд-ния ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

I I Bokin

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

канд. мед. наук, доц. каф. онкологии ФГБОУ ДПО РМАНПО 123995, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

R I Knyazev

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

канд. мед. наук, ассистент каф. онкологии ФГБОУ ДПО РМАНПО 123995, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

M D Akhmedova

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

канд. мед. наук, врач отд-ния ультразвуковой диагностики ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

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