Regulatory T-cells (Treg) in lymphoproliferative diseases


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Abstract

To purpose of the study was to research the level of regulatory T-lymphocytes (Treg) in lymphoproliferative diseases, and to evaluate their response to chemoradiotherapy. 71 studies of peripheral blood in patients with Hodgkin's lymphoma - HL (7), non-Hodgkin's lymphoma - nonHL (33) and chronic lymphocytic leukemia - CLL (31) were carried out. The phenotype of Treg cells was determined by flow cytometry as a CD45+CD4+CD25+CD127-. The increased levels of regulatory T-cells in lymphoproliferative diseases (HL, NHL and CLL) are detected, as well as their relative resistance to the components of chemoradiation therapy.

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E G Kuzmina

A.F.Tsyb Medical Radiological Research Center - Branch of National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Email: kuzmina_e_g@mail.ru
канд. биол. наук, зав. лаб. клин. иммунологии МРНЦ им. А.Ф.Цыба - филиала ФГБУ НМИРЦ 249036, Russian Federation, Obninsk, ul. Koroleva, d. 4

T Yu Mushkarina

A.F.Tsyb Medical Radiological Research Center - Branch of National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

науч. сотр. лаб. клин. иммунологии МРНЦ им. А.Ф.Цыба - филиала ФГБУ НМИРЦ 249036, Russian Federation, Obninsk, ul. Koroleva, d. 4

T V Konstantinova

A.F.Tsyb Medical Radiological Research Center - Branch of National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

науч. сотр. лаб. клин. иммунологии МРНЦ им. А.Ф.Цыба - филиала ФГБУ НМИРЦ 249036, Russian Federation, Obninsk, ul. Koroleva, d. 4

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