Prospects for revision of the histological classification of neuroendocrine tumorsBased on the materials of 11-th Annual European Neuroendocrine Tumor Society Conference


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Abstract

The revision of the classification of neuroendocrine tumors (NETs), such as gastrointestinal (GI), pancreatic (PETs) and lungs tumors, according to the new approaches to determine the tumor grade (Grade) is becoming increasingly important. All these tumors differ according to the clinical course and response to different therapeutic regimens. 11-th annual European Neuroendocrine Tumor Society Conference (ENETS), which took place on 5-7 March 2014 in Barcelona (Spain), had been devoted to the choice of new thresholds of mitotic index and Ki-67 proliferation index to make changes in the gradation system of GI NETs and PETs and to divide the previous groups G2 and G3 into the subunits. Besides, it was suggested to unify the lung and GI NETs terminology and to divide lung NETs in to the G1, G2 and G3 groups, according to the threshold levels of mitotic index and Ki-67 proliferation index, concerning the localization of these tumors.

About the authors

L E Gurevich

ГБУЗ МО МОНИКИ им. М.Ф.Владимирского

д-р биол. наук, проф., вед. науч. сотр. патологоанатомического отд-ния

V V Delectorskaya

ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН, Москва

д-р мед. наук, зав. лаб. гистохимии и электронной микроскопии

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