Mobilization of hematopoietic stem cells (HSCs) by using Pleriksafor (Mozobail) in combinationwith colony-stimulating factor in patients with previous failure transplant procurement for autotransplantation of HSCs


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Abstract

AutoHSCT is an effective treatment for patients with relapsed and refractory lymphomas, multiple myeloma, some solid tumors. For a successful transplantation it is necessary to obtain an adequate quality and quantity transplant. Due to the heavy pretreatment this category of patients receiving a transplant can be a serious problem, which can be solved with the use of the new mobilizing agent inhibitor CXCR4 - plerixafor. In our study, 10 patients, of which 7 were confirmed as «poor mobilizers» were stimulated with colony stimulating factor, together with a plerixafor dose 0,24 mg/kg body weight on day 5 and 6 of stimulation. In 9 of the 10 patients we had obtained an adequate transplant. In all patients before the administration of plerixafor low or intermediate number of CD34+ cells per microliter of peripheral blood was obtained. The patient failed to mobilize with the use of plerixafor mentioned the smallest number of CD34+ cells per microliter in peripheral blood both before and after administration of plerixafor. In 9 patients, the content of CD34+ cells after stimulation with plerixafor increased by 2-4 times.

About the authors

N B Mikhailova

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

канд. мед. наук, рук. отд-ния онкологии НИИ нефрологии ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

A L Alianskij

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

зав. лаб. «Регистр доноров костного мозга»

E V Kondakova

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

канд. мед. наук, врач-гематолог отд-ния трансплантации костного мозга для детей с онкологическими заболеваниями

U R Zalyalov

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

канд. мед. наук, врач-гематолог поликлин. отд-ния с дневным стационаром

E V Babenko

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

зав. отд-нием криоконсервации с лаб. контроля качества гемопоэтических клеток

V S Sergeev

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

зав. лаб. трансплантационной иммунологии

M A Estrina

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

зав. отд-нием клин. трансфузиологии

M A Kucher

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

канд. мед. наук, врач-анестезиолог-реаниматолог отд-ния реанимации и интенсивной терапии

A D Kulagin

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

канд. мед. наук, зав. поликлин. отд-нием с дневным стационаром

E S Borzenkova

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

врач-гематолог поликлин. отд-ния с дневным стационаром

B V Afanasiev

НИИ детской онкологии, гематологии и трансплантологии им. Р.М.Горбачевой ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

д-р мед. наук, проф., дир. НИИДОГиТ им. Р.М.Горбачевой, зав. каф. гематологии, трансфузиологии и трансплантологии ФПО ГБОУ ВПО ПСПбГМУ им. акад. И.П.Павлова

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