The ways of erlotinib resistance overcoming in treatment of patients with eGFr mutated nsClC


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Abstract

The aspects of chemotherapy and erlotinib combination to treatment of non-small-cell lung cancer (NSCLC) are examined in the article. Mechanisms of ITK resistance acquiring and potential ways to its overcoming are discussed. In the randomized clinical trial FASTACT-II the intercalated combination of chemotherapy and erlotinib was used in the 1st line treatment of NSCLC. The efficacy of new approach was proved to Asian patients with EGFR mutated NSCLC.

About the authors

S V Orlov

Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова

д-р мед. наук, проф., вед. науч. сотр. отд. онкологии

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