Email this article Efficiency of denosumab in giant cell tumor of the bone
- Authors: Semenov NN1
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Affiliations:
- ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН, Москва
- Issue: Vol 15, No 2 (2013)
- Pages: 54-56
- Section: Articles
- URL: https://journals.rcsi.science/1815-1434/article/view/26908
- ID: 26908
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Abstract
Studies of the mechanisms of giant cell tumor of the bone have confirmed the pivotal role of the RANK-RANKL-OPG (receptor activator of nuclear factor kappa-b – receptor activator of nuclear factor kb ligand – osteopretegerin ligand) system and also shown that stromal cells (spindle-shaped fibroblasts) carry a tumor potential. The paper gives the results of 2 investigations of the novel monoclonal antibody denosumab, an osteoprotegerin analogue, in 199 patients with giant cell tumor of the bone. Both X-ray evaluation and morphological re-examination of the tumor revealed the high efficacy of denosumab, which was attended by normalization of enhanced osteolysis. It was shown that there was a possibility of performing the lower volume of surgery or postponing the latter to a later time in patients with a potentially operable tumor, without causing damage to them.
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##article.viewOnOriginalSite##About the authors
N N Semenov
ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН, Москва
Email: niksemenov1969@yandex.ru
д-р мед. наук, ст. науч. сотр. отд-ния химиотерапии и комбинированного лечения злокачественных опухолей
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