The role of direct oral anticoagulants in cancer-associated thrombosis. Review of clinical guidelines and real practice

Cover Page

Cite item

Full Text

Abstract

Oncology is one of the undisputable leaders of the present day medicine in terms of innovations and research. Globalization and a high number of randomized clinical trials generate an ever increasing amount of new data, clinical guidelines on cancer treatment, complications prevention and supportive care. Modern oncology practice demands vast and firm knowledge on venous thromboembolism treatment and prevention. The article is a survey of the present day clinical guidelines and real world data in the field of cancer-associated thrombosis.

About the authors

Oleg S. Tereshin

Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine

Author for correspondence.
Email: olegter@mail.ru
ORCID iD: 0000-0002-2906-6391

Cand. Sci. (Med.), Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine

Russian Federation, Chelyabinsk

References

  1. Lee AY, Rickles FR, Julian JA, et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism. J Clin Oncol. 2005;23(10):2123-9. doi: 10.1200/JCO.2005.03.133
  2. Prins MH, Lensing AW, Brighton TA, et al. Oral rivaroxaban versus enoxaparin with vitamin K antagonist for the treatment of symptomatic venous thromboembolism in patients with cancer (EINSTEIN-DVT and EINSTEIN-PE): A pooled subgroup analysis of two randomised controlled trials. Lancet Haematol. 2014;1(1): e37-46. doi: 10.1016/S2352-3026(14)70018-3
  3. Agnelli G, Buller HR, Cohen A, et al. Oral apixaban for the treatment of venous thromboembolism in cancer patients: Results from the AMPLIFY trial. J Thromb Haemost. 2015;13(12):2187-91. doi: 10.1111/jth.13153
  4. Young AM, Marshall A, Thirlwall J, et al. Comparison of an Oral Factor Xa Inhibitor with Low Molecular Weight Heparin in Patients with Cancer with Venous Thromboembolism: Results of a Randomized Trial (SELECT-D). J Clin Oncol. 2018;36(20):2017-23. doi: 10.1200/JCO.2018.78.8034
  5. Mulder FI, van Es N, Kraaijpoel N, et al. Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study. Thromb Res. 2020;185:13-9. doi: 10.1016/j.thromres.2019.11.007
  6. McBane RD 2nd, Wysokinski WE, Le-Rademacher JG, et al. Apixaban and dalteparin in active malignancy-associated venous thromboembolism: The ADAM VTE trial. J Thromb Haemost. 2020;18(2):411-21. doi: 10.1111/jth.14662
  7. Agnelli G, Becattini C, Meyer G, et al; Caravaggio Investigators. Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer. N Engl J Med. 2020;382(17):1599-607. doi: 10.1056/NEJMoa1915103
  8. Ageno W, Vedovati MC, Cohen A, et al. Bleeding with Apixaban and Dalteparin in Patients with Cancer-Associated Venous Thromboembolism: Results from the Caravaggio Study. Thromb Haemost. 2021;121(5):616-24. doi: 10.1055/s-0040-1720975
  9. Бокерия Л.А., Затевахин И.И., Кириенко А.И., и др. Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений. Флебология. 2015;9(4-2):3-52 [Bokeria LA, Zatevahin II, Kirienko AI, et al. Russian clinical guidelines on diagnostics treatment and prevention of venous thromboembolism. Flebologiya. 2015;9(4-2):3-52 (in Russian)].
  10. Cеливерстов Е.И., Лобастов К.В., Илюхин Е.А., и др. Профилактика, диагностика и лечение тромбоза глубоких вен. Рекомендации российских экспертов. Флебология. 2023;17(3):152-296 [Seliverstov EI, Lobastov KV, Ilyuhin EA, et al. Prevention diagnostics and treatment of venous thromboembolism. Expert guidelines. Flebologiya. 2023;17(3):152-296 (in Russian)]. doi: 10.17116/flebo202317031152
  11. Сомонова О.В., Антух Э.А., Варданян А.В., и др. Практические рекомендации по профилактике и лечению тромбоэмболических осложнений у онкологических больных. Злокачественные опухоли. 2022;12(3s2-2):159-70 [Somonova OV, Antukh EA, Vardanyan AV, et al. Practical guidelines on prevention and treatment of venous thromboembolism in oncology patients. Zlokachestvennye opukholi. 2022;12(3s2-2):159-70 (in Russian)].
  12. Сомонова О.В., Антух Э.А., Варданян А.В., и др. Практические рекомендации по профилактике и лечению тромбоэмболических осложнений у онкологических больных. Практические рекомендации RUSSCO, часть 2. Злокачественные опухоли. 2023;13(3s2):167-78 [Somonova OV, Antukh EA, Vardanyan AV, et al. Practical guidelines on prevention and treatment of venous thromboembolism in oncology patients. Zlokachestvennye opukholi. 2023;12(3s2):167-78 (in Russian)].
  13. National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology: Cancer-Associated Venous Thromboembolic Disease; 2023. Available at: https://www.nccn.org/guidelines/guidelines-detail?category=3&id=1423. Accessed: 01.12.2023.
  14. Kearon C, Akl EA, Ornelas J, et al. Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel report. Chest. 2016;149:315-52.doi: 10.1016/j.chest.2015.11.026
  15. Stevens SM, Woller SC, Baumann Kreuziger L, et al. Antithrombotic Therapy for VTE Disease Second Update of the CHEST Guideline and Expert Panel Report. Chest. 2021;160(6):e545-608. doi: 10.1016/j.chest.2021.07.055
  16. Khorana AA, Noble S, Lee AYY, et al. Role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism: Guidance from the SSC of the ISTH. J Thromb Haemost. 2018;16(9):1891-4. doi: 10.1111/jth.14219
  17. Wang T, Zwicker JI, Ay C, et al. The use of direct oral anticoagulants for primary thromboprophylaxis in ambulatory cancer patients: Guidance from the SSC of the ISTH. J Thromb Haemost. 2019;17(10):1772-8. doi: 10.1111/jth.14564
  18. Key NS, Khorana AA, Kuderer NM, et al. Venous Thromboembolism Prophylaxis and Treatment in Patients with Cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol. 2023;41(16):3063-71. doi: 10.1200/JCO.23.00294
  19. Lyman GH, Carrirer M, Ay C, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: Prevention and treatment in patients with cancer. Blood Adv. 2021;5(4):927-74. doi: 10.1182/bloodadvances.2021004734
  20. Kakkos SK, Gohel M, Baekgaard N, et al. Editor’s Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis. Eur J Vasc Endovasc Surg. 2021;61(1):9-82. doi: 10.1016/j.ejvs.2020.09.023
  21. Khorana AA, McCrae KR, Milentijevic D, et al. Current practice patterns and patient persistence with anticoagulant treatments for cancer-associated thrombosis. Res Pract Thromb Haemost. 2017;1(1):14-22. doi: 10.1002/rth2.12002
  22. Cohen A, Keshishian A, Lee T, et al. Effectiveness and safety of apixaban, low-molecular-weight heparin, and warfarin among venous thromboembolism patients with active cancer: A U.S. claims data analysis. Thromb Haemost. 2021;121(3):383-95. doi: 10.1055/s-0040-1718728
  23. Bertoletti L, Gusto G, Khachatryan A, et al. Anticoagulant Treatment Patterns and Outcomes in Patients with Venous Thromboembolism and Active Cancer – a Nationwide Cohort Study in France. Blood. 2021;138(Suppl. 1):670. doi: 10.1182/blood-2021-147748
  24. Lotya J, Dhamane A, Rosenblatt L, et al. Discordance between Treatment Guideline Recommendations and Real-World Practice in a Group of Large Integrated Delivery Networks for Venous Thromboembolism (VTE) Patients: A Closer Look at VTE Patients with Cancer. Blood. 2021;138(Suppl. 1):1951.

Copyright (c) 2024 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies