Heterogeneous diffuse large B-cell lymphoma: accurate diagnosis as a key to successful therapy. A review
- Authors: Babicheva L.G.1, Poddubnaya I.V.1
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 25, No 2 (2023)
- Pages: 168-177
- Section: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/132814
- DOI: https://doi.org/10.26442/18151434.2023.2.202237
- ID: 132814
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Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common variant of non-Hodgkin's lymphoma and accounts for about 1/3 of all non-Hodgkin's lymphomas in Western countries and about 40% of B-cell tumors worldwide. Correct diagnosis of clinically distinct subgroups of aggressive mature B-cell lymphomas is crucial for the choice of adequate treatment. Currently, the identification of DLBCL subtype depends on a combination of morphologic, immunophenotypic, and cytogenetic/molecular features. The classification covers the most common unspecified variant of DLBCL, also referred to as "not otherwise specified" (NOS), and a number of other rare forms. Over the past two decades, DLBCL NOS which accounts for more than 80% of all cases, has been the subject of a growing number of molecular studies that have identified prognostic factors that are being actively introduced into real-world clinical practice. Only the integration of morphological, immunohistochemical and molecular features of DLBCL will lead to the achievement of the long-term goal of curing the majority of patients with minimal or no toxic manifestations with the aid of personalized healthcare.
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##article.viewOnOriginalSite##About the authors
Lali G. Babicheva
Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: lalibabicheva@mail.ru
ORCID iD: 0000-0001-8290-5564
Cand. Sci. (Med.)n Medical Academy
Russian Federation, MoscowIrina V. Poddubnaya
Russian Medical Academy of Continuous Professional Education
Email: ivprectorat@inbox.ru
ORCID iD: 0000-0002-0995-1801
D. Sci. (Med.), Prof., Acad. RASn
Russian Federation, MoscowReferences
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