Impact of diagnostic criteria for asymptomatic bacteriuria on obstetric outcomes and urological complications during pregnancy
- Authors: Tcukanov A.Y.1, Savelieva I.V.1, Kulchavenya E.V.2,3, Ibishev K.S.4, Firsov M.A.5,6, Alekseeva E.A.5,6, Dugarzhapova T.O.6, Krivchik G.V.1, Baipakova M.I.1, Treyvish L.S.1
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Affiliations:
- FGBOU VO «Omsk State Medical University»
- FGBOU VO Novosibirsk State Medical University of Ministry of Health of Russia
- Medical Center “Avicenna” of the group of companies "Mother and Child"
- Rostov State Medical University, Ministry of Health of Russia
- FGBOU VO Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Health of Russia
- KGBUZ “Krasnoyarsk Region Clinical Hospital”
- Issue: No 3 (2024)
- Pages: 33-38
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1728-2985/article/view/262404
- DOI: https://doi.org/10.18565/urology.2024.3.33-38
- ID: 262404
Cite item
Abstract
Aim. To study obstetric outcomes and urological complications using various diagnostic criteria for asymptomatic bacteriuria (AB) in pregnant women.
Materials and methods. A multicenter, retrospective, non-interventional, descriptive, parallel-group study was carried out. A total of 225 pregnant women with AB aged 18 to 45 years were included. They underwent bacteriological examination of urine. After the examination, patients were divided into 5 groups. Group 1 (n=82) included patients with 1 urine culture and antimicrobial treatment. Group 2 (n=57) included patients with 2 urine cultures and antimicrobial treatment. Group 3 (n=16) included patients with positive criteria for bacteriuria, but who refused treatment. In group 4 (n=51), there were women with uncomplicated pregnancy. Group 5 (n=19) included patients with bacteriuria, which did not meet the criteria for AB (<105).
Results. Based on the results of 225 patients (average age 28±5.5 years), preterm birth occurred significantly more often in all groups when AB was detected, regardless of treatment, in comparison with a normal pregnancy. In patients of groups 2, 3, 5, preeclampsia was significantly more common. There were no significant differences in complications such as arterial hypertension and amnionitis.
Urological complications. The degree of AB and administration of treatment did not affect the incidence of pyelonephritis or obstetric outcomes. However, in group 1 there was a weak tendency towards a more frequent development of pyelonephritis in the 3rd trimester.
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##article.viewOnOriginalSite##About the authors
A. Yu. Tcukanov
FGBOU VO «Omsk State Medical University»
Author for correspondence.
Email: autt@mail.ru
ORCID iD: 0000-0002-3497-5856
Ph.D., MD, professor, Head of the Department of Surgical Diseases and Urology
Russian Federation, OmskI. V. Savelieva
FGBOU VO «Omsk State Medical University»
Email: saveljeva_iv_omsk@mail.ru
ORCID iD: 0000-0003-0464-4084
Ph.D., MD, associate professor, Head of the Department of Obstetrics and Gynecology No. 1
Russian Federation, OmskE. V. Kulchavenya
FGBOU VO Novosibirsk State Medical University of Ministry of Health of Russia; Medical Center “Avicenna” of the group of companies "Mother and Child"
Email: urotub@yandex.ru
ORCID iD: 0000-0001-8062-7775
Ph.D., MD, professor, professor at the Department of Phthisiopulmonology, Scientific Chief
Russian Federation, Novosibirsk; NovosibirskKh. S. Ibishev
Rostov State Medical University, Ministry of Health of Russia
Email: Ibishev22@mail.ru
ORCID iD: 0000-0002-2954-842X
Ph.D., MD, Professor of the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)
Russian Federation, Rostov-on-DonM. A. Firsov
FGBOU VO Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Health of Russia; KGBUZ “Krasnoyarsk Region Clinical Hospital”
Email: firsma@mail.ru
ORCID iD: 0000-0002-0887-0081
Ph.D., associate professor, Head of the Department of Urology, Andrology and Sexology, Chief soecialist on urology
Russian Federation, Krasnoyarsk; KrasnoyarskE. A. Alekseeva
FGBOU VO Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Health of Russia; KGBUZ “Krasnoyarsk Region Clinical Hospital”
Email: vohminak@mail.ru
ORCID iD: 0000-0002-8215-9095
Ph.D., associate professor of the Department of Urology, Andrology and Sexology
Russian Federation, Krasnoyarsk; KrasnoyarskT. O. Dugarzhapova
KGBUZ “Krasnoyarsk Region Clinical Hospital”
Email: dto93@mail.ru
ORCID iD: 0000-0003-2606-9914
urologist
Russian Federation, KrasnoyarskG. V. Krivchik
FGBOU VO «Omsk State Medical University»
Email: krivchikgalina@yandex.ru
ORCID iD: 0009-0000-0336-5425
Ph.D., associate professor at the Department of Obstetrics and Gynecology No. 1, Deputy Chief on Outpatient Department
Russian Federation, OmskM. I. Baipakova
FGBOU VO «Omsk State Medical University»
Email: m.madina.i1108@gmail.com
ORCID iD: 0009-0008-0306-5148
2nd year resident at the Department of Surgical Diseases and Urology
Russian Federation, OmskL. S. Treyvish
Email: ms.lubov_tr@mail.ru
ORCID iD: 0000-0002-5435-2955
Ph.D., Head of the Department of Obstetrics and Gynecology, obstetrician-gynecologist, pediatric gynecologist and gynecologist-endocrinologist
Russian FederationReferences
- Naboka Y.L., Rymashevsky A.N., Kogan O.M., Gudima I.A., Vorobyova N.V., Alkina A.K. Asymptomatic bacteriuria and pyelonephritis during pregnancy. 2021. doi: 10.21886/2219-8075-2021-12-3-22-31. Russian (Набока Ю.Л., Рымашевский А.Н., Коган О.М., Гудима И.А., Воробьева Н.В., Алькина А.К. Бессимптомная бактериурия и пиелонефрит при беременности. 2021. doi: 10.21886/2219-8075-2021-12-3-22-31).
- Clinical recommendations: «Normal pregnancy», 2020. Russian (Клинические рекомендации: «Нормальная беременность», 2020).
- EAU GUIDELINES, 2023.
- Михайлова О.И., Арушанова А.Г., Аношин А.С., Кан Н.Е., Тютюнник В.Л. Принципы антибактериальной терапии при инфекции мочевыводящих путей у беременных. Акушерство и гинекология. 2016;2:12.
- Borzenkova E.A., Kokhanova D.A., Zhilyaeva D.V., Mamina Y.R., Moskovskaya L.V. The effect of asymptomatic bacteriuria on the course of pregnancy and childbirth. Forcipe. 2019;2(S1):134–135. Russian (Борзенкова Е.А., Коханова Д.А., Жиляева Д.В., Мамина Ю.Р., Московская Л.В. Влияние бессимптомной бактериурии на течение беременности и родов. Forcipe. 2019;2(S1):134–135).
- Clinical recommendations: «Bacteriological urine culture», 2014. Russian (Клинические рекомендации: «Бактериологический посев мочи», 2014).
- Antibiotics for asymptomatic bacteriuria in pregnancy. Fiona M Smaill, Juan C Vazquez. Cochrane library, 2019.
- The Lancet Infectious Diseases. Management of asymptomatic bacteriuria in pregnant women. Lindsay E Nicolle/ August 05,2015.
- Kass E.H. Asymptomatic infections of the urinary tract. Trans Assoc Am Physicians. 1956;56. hhtps://pubmed.ncbi.nlm.nih.gov/13380946/.
- Menshikov V.V. Methods of clinical laboratory research. M.: Labora. 2009; 880 p. Russian (Меньшиков В.В. Методики клинических лабораторных исследований. М: Лабора. 2009; 880 с.).
- Kogan M.I., Naboka Y.L., Gudima I.A., Vorob’yeva N.V. Asymptomatic bacteriuria in pregnant women – the normal condition of healthy women urine. Urologiia. 2022;6:5–8. doi: 10.18565/urology.2022.6.5-8 Коган М.И., Набока Ю.Л., Гудима И.А., Воробьева Н.В. Асимптоматическая бактериурия у беременных – нормальное состояние мочи здоровой женщины. Урология. 2022. https://doi.org/10.18565/urology.2022.6.5-8
- Kogan M.I., Naboka Y.L., Ibishev KS., Gudima I.A., Naber K.G. Human Urine Is Not Sterile – Shift of Paradigm. Urol. Int. 2015;94(4):445–452. doi: 10.1159/000369631.
- Naboka Y.L., Il’yash A.V., Krakhotkin D.V. Virus and bacterial associations verified in the urine of healthy subjects (pilot study). Vestnik urologii. 2018;6(3):44–49. doi: 10.21886/2308-6424-2018-6-3-44-49. Russian (Набока Ю.Л., Ильяш А.В., Крахоткин Д.В. Вирусо-бактериальные ассоциации, верифицированные в моче здоровых людей (пилотное исследование). Вестник урологии. 2018;6(3):44–49).
- Naboka Y.L., Gudima I.A., Mordanov S.V., Krakhotkin D.V., Il’yash A.V., Kogan M.I, Sizyakin D.V., Ibishev K.S. Virusuria as a constituent of the urinary microbiota and its implications for assessing urinary tract health status: a descriptive clinical study. Urologiia. 2020;1:12–18. Russian (Набока Ю.Л., Гудима И.А., Морданов С.В., Крахоткин Д.В., Ильяш А.В., Коган М.И., Сизякин Д.В., Ибишев Х.С. Вирусурия как составляющая микробиоты мочи и ее значение для оценки состояния здоровья мочевого тракта: описательное клиническое исследование. Урология. 2020;1:12–18).
- Maghdid D.M., Kok D.J. Urine si not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder. Urol. 2014;66(5):966.
- Pohl H.G., Groah S.L., Pérez-Losada M., Ljungberg I., Sprague B.M., Chandal N., Caldovic L., Hsieh M. The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method. Int Neurourol. J. 2020;24(1):41–51. doi: 10.5213/inj.1938244.122.
- Hilt E.E., McKinly K., Pearce M.M., Rosenfeld A.B., Zilliox M.J., Mueller E.R., Brubacer L., Gai X., Wolfe A.J., Schreckenberger P.C. Urine is not sterile: use of enchanced urine culture techiques to detect resident bacterial flora in the adult female bladder. J Clin Microbiol. 2014;52(3):871–876. doi: 10.1128/JCM.02876-13.
- The Lancet Infectious Diseases. Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial. Brenda M Kazemier, Fiona N Koningstein, Caroline Schneeberger , Alewijn Ott , Patrick M Bossuyt, Esteriek de Miranda, Tatjana E Vogelvang, Corine J M Verhoeven, Josje Langenveld, Mallory Woiski, Martijn A Oudijk, Jeanine E M van der Ven, Manita T W Vlegels, Petra N Kuiper, Nicolette Feiertag, Eva Pajkrt, Christianne J M de Groot, Ben W J Mol, Suzanne E Geerlings. Doi: doi.org/10.1016/S1473-3099(15)00070-5
- Kenyon S., Pike K., Jones D.R., Brocklehurst P., Marlow N., Salt A., Taylor D.J. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. The Lancet. 2008;372(9646):1319–1312. doi: 10.1016/S0140-6736(08)61203-9.
- Kenyon S., Pike K., Jones D.R. et al. Childhood outcomes after prescription of antibiotics with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. Lancet. 2008;372(9646):1310–1318.
- Clinical recommendations: Urinary tract infections during pregnancy. https://cr.minzdrav.gov.ru/recomend/719_. Russian (Клинические рекомендации: Инфекции мочевых путей при беременности. https://cr.minzdrav.gov.ru/recomend/719_1).