Evaluation of the efficiency and safety of the dispersed form of sildenafil (50 mg) in males with erectile dysfunction
- Authors: Al-Shukri A.S.1, Dub N.I.2, Maksimova A.V.1, Konyushiy V.S.2, Petrov S.B.1
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Affiliations:
- FGBOU VO Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
- FGBVOU VO S.M. Kirov Military Medical Academy of the Ministry of Defense of Russian Federation
- Issue: No 3 (2023)
- Pages: 52-57
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1728-2985/article/view/258057
- DOI: https://doi.org/10.18565/urology.2023.3.52-57
- ID: 258057
Cite item
Abstract
Introduction. The erectile dysfunction is defined as an inability to achieve or maintain an erection sufficient for sexual intercourse lasting more than 3 months. According to literature, about 90 million men worldwide suffer from erectile dysfunction of different severity.
Aim. To evaluate the efficacy and safety of the dispersed form of sildenafil ("Ridzhamp" 50 mg), compared with the standard tablets of sildenafil (50 mg).
Materials and methods. The study included 60 men aged 27 to 67 years (average age 40.2 years) with moderate erectile dysfunction (11-15 points according to IIEF-5). In group I (n=30), patients took a dispersible form of the drug sildenafil, 50 mg ("Ridzhamp") 60 minutes before sexual intercourse; in group II (n=30), a standard form of the drug sildenafil was prescribed at a dosage of 50 mg, 60 minutes before sexual intercourse.
Results. Positive dynamics according to IIEF-5 score was found in all the study groups. In group I, IIEF-5 score increase by 53.85%, while in group II by 50% (p<0.05). The average onset of erection in group I was 45±2.2 min, while in group II it was 51±1.9 min. In the main group (group I) one patient (3.33%) complained of persistent headache after taking the drug, and therefore refused the therapy. In the comparison group (group II) one patient (3.33%) reported dyspeptic disorders while taking the drug, 1 patient (3.33%) reported dizziness. All patients in the main group noted the convenience of taking the «Ridzhamp».
Conclusions. Our results indicate the comparable efficiency of the dispersed form of sildenafil (group I) and the standard tablet form of the drug (group II). All patients in the main group (group I) noted a faster onset of erections, as well as the convenience of «Ridzhamp» and the ability to take the drug without water intake.
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##article.viewOnOriginalSite##About the authors
A. S. Al-Shukri
FGBOU VO Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
Author for correspondence.
Email: ad330@mail.ru
ORCID iD: 0000-0001-6543-8589
Scopus Author ID: 28367540300
Ph.D., MD, professor, Head of the Urological Department No1 (general and emergent urology) of Scientific and Research Center of Urology of Scientific and Research Institute of Surgery and Emergent Medicine
Russian Federation, Saint PetersburgN. I. Dub
FGBVOU VO S.M. Kirov Military Medical Academy of the Ministry of Defense of Russian Federation
Email: dubnikita1998@gmail.com
ORCID iD: 0000-0002-4049-4178
student
Russian Federation, Saint PetersburgA. V. Maksimova
FGBOU VO Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
Email: maksimova_av77@mail.ru
ORCID iD: 0000-0002-5627-2596
student
Russian Federation, Saint PetersburgV. S. Konyushiy
FGBVOU VO S.M. Kirov Military Medical Academy of the Ministry of Defense of Russian Federation
Email: dr.vitalikoniushii@mail.ru
ORCID iD: 0009-0003-2680-4509
cadet
Russian Federation, Saint PetersburgS. B. Petrov
FGBOU VO Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia
Email: petrov@urology.spb.ru
ORCID iD: 0000-0003-3460-3427
Ph.D., MD, professor, Head of the Scientific and Research Center of Urology of Scientific and Research Institute of Surgery and Emergent Medicine
Russian Federation, Saint PetersburgReferences
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