Gender influence on the level of expression of oral fluid biomarkers

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The purpose — to determine the level of expression in the oral fluid of matrix metalloproteinases (MMPs) of types 2, 8 and 9, as well as their tissue inhibitors (TIMPs) of types 1 and 2, depending on the presence or absence of a number of components of the dental status.
Material and methods. The results of a study of the level of expression of oral fluid biomarkers of 19 patients with different levels of dental health who do not have a history of history are presented. Previously, a dental examination of patients was carried out and the occurrence of signs of dental status was determined.
Results and discussion. Analysis of expression levels of matrix metalloproteinases and their tissue inhibitors showed significant differences in performance.
Conclusions. The data obtained suggest a significant impact of the state of dental health mainly on the level of MMP-2 and MMP-9, the indicators of which differ 2 times from the same in the opposite sex, with other conditions being almost the same (age, general health).

作者简介

Ekaterina Kochurova

Sechenov First Moscow State Medical University of Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: evkochurova@mail.ru

MD, DMD, PhD, Professor of the Department of prosthetic dentistry, I.M. Sechenov First Moscow State Medical University

俄罗斯联邦, Moscow

E. Kudasova

Sechenov First Moscow State Medical University of Ministry of Health of the Russian Federation

Email: evkochurova@mail.ru
俄罗斯联邦, Moscow

Yu. Podolskii

Sechenov First Moscow State Medical University of Ministry of Health of the Russian Federation

Email: evkochurova@mail.ru
俄罗斯联邦, Moscow

L. Gavryushova

V.I. Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation

Email: evkochurova@mail.ru
俄罗斯联邦, Saratov

E. Izhnina

Kuban State Medical University of Ministry of Health of the Russian Federation

Email: evkochurova@mail.ru
俄罗斯联邦, Krasnodar

参考

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