Study of coordinated regulation of expression of tnfa and matrix metalloproteinases MMP8 and MMP9 in periodontal tissue in health and pathology


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A qPCR method combined with reverse transcription applicable for obtaining reproducible results of mRNA analysis of human periodontal swabs is established. A positive correlation between mRNA of TNFa, MMP8, MMP9 in healthy periodontal tissue is demonstrated. This correlation is not found in patients with chronic periodontitis. A mechanism of TNFa-dependent induction of MMP8 and MMP9 induction is found to be pronounced in men than in women.

作者简介

Oksana Zorina

Sechenov First Moscow State Medical University; Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation

Email: zorina-cniis@yandex.ru
doctor of medicine, professor, I.M. Sechenov First Moscow State Medical University, Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation 199911, Moscow

N. Aymadinova

Sechenov First Moscow State Medical University

199911, Moscow

O. Boriskina

Sechenov First Moscow State Medical University; Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation

199911, Moscow

A. Shevelev

Chumakov institute of poliomyelitis and viral encephalitides

142782, Moscow

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