Features of pain sensitivity during premedication with xenon in patients before outpatient dental interventions
- 作者: Shugailov I.A.1, Moskovets O.N.2, Sergeeva J.I.1, Drobyshev A.Y.2, Chausskaja I.Y.2
- 
							隶属关系: 
							- Academy of Innovative Stomatology
- Russian University of Medicine
 
- 期: 卷 28, 编号 1 (2024)
- 页面: 21-28
- 栏目: Clinical Investigation
- URL: https://journals.rcsi.science/1728-2802/article/view/264175
- DOI: https://doi.org/10.17816/dent323125
- ID: 264175
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BACKGROUND: Premedication in outpatient dental interventions normalizes pain sensitivity and emotional state of patients. Inhalation of xenon-oxygen mixture can be an effective means for it.
AIM: To study the effect of xenon premedication on pain sensitivity in patients with outpatient dental interventions.
MATERIALS AND METHODS: Twenty patients were studied. Emotional and personal characteristics of patients were determined using the Eysenck test, Spielberger–Khanin personal anxiety scale, and hospital scale of anxiety and depression. Pain sensitivity was assessed using pain thresholds and somatosensory evoked potentials of the brain before and after inhalation of xenon-oxygen mixture at a concentration of 30/70 for 3 minutes.
RESULTS: According to the results of psychological testing, all examined patients were characterized by a stable psychological sphere and predominantly lowered anxiety and constituted a group with insignificantly different emotional and personal characteristics. Before inhalation, pain sensitivity in patients varied significantly. After inhalation, multidirectional changes in pain sensitivity occurred, which were expressed in a decrease and an increase in pain sensitivity thresholds and the degree of activation of brain structures.
CONCLUSION: Preoperative stress can both exacerbate and reduce pain sensitivity in patients. The use of inhalation of a xenon-oxygen mixture at a concentration of 30/70 for 3 minutes as a premedication causes multidirectional changes in the sensitivity of tissues and organs in the maxillofacial region in patients before outpatient dental interventions, which may be caused by a change in the activity of endogenous antinociceptive (analgesic) system.
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作者简介
Igor Shugailov
Academy of Innovative Stomatology
														Email: 9978753@mail.ru
				                	ORCID iD: 0000-0001-5304-6078
				                	SPIN 代码: 5681-7569
																		                												                	俄罗斯联邦, 							Москва						
Oleg Moskovets
Russian University of Medicine
							编辑信件的主要联系方式.
							Email: moskovets.oleg@yandex.ru
				                	ORCID iD: 0000-0001-9686-1769
				                	SPIN 代码: 8110-8715
																		                												                	俄罗斯联邦, 							Moscow						
Julia Sergeeva
Academy of Innovative Stomatology
														Email: 0196268@gmail.com
				                	ORCID iD: 0000-0002-2703-1056
				                	SPIN 代码: 4515-2220
																		                												                	俄罗斯联邦, 							Moscow						
Alexey Drobyshev
Russian University of Medicine
														Email: dr.drobyshev@gmail.com
				                	ORCID iD: 0000-0002-1710-6923
				                	SPIN 代码: 6683-8226
																		                												                	俄罗斯联邦, 							Moscow						
Irina Chausskaja
Russian University of Medicine
														Email: dr.chausskaya@mail.ru
				                	ORCID iD: 0000-0001-9674-1919
				                	SPIN 代码: 2957-4091
																		                												                	俄罗斯联邦, 							Moscow						
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- Zubieta JK, Smith YR, Bueller JA, et al. μ-opioid receptor-mediated antinociceptive responses differ in men and women. J Neurosci. 2002;22(12):5100–5107. doi: 10.1523/JNEUROSCI.22-12-05100.2002
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