PATHOLOGIC FEATURES OF PERIODONTAL TISSUES IN EXPERIMENTAL OSTEOPOROSIS
- Authors: Bykova N.I1, Kobylkina T.L2, Grigoryan V.A2, Adamchik A.A3, Arutyunov A.V3
-
Affiliations:
- Department of pediatric dentistry, orthodontics and oral and maxillofacial surgery Kuban state medical University, Russian Ministry of health
- Department of dentistry Stavropol State Medical University Ministry of health of Russia
- Department of therapeutic dentistry Kuban state medical University, Russian Ministry of health
- Issue: Vol 21, No 2 (2017)
- Pages: 76-78
- Section: Articles
- URL: https://journals.rcsi.science/1728-2802/article/view/42096
- DOI: https://doi.org/10.18821/1728-28022017;21(2):76-78
- ID: 42096
Cite item
Full Text
Abstract
The article presents information about some pathological changes in periodontal tissues during experimental osteoporosis. The experiments were conducted on 8 three-year sheep, which have at different times after ovariectomy removed dentoalveolar segments in the region of incisors of the lower jaw. Pathological changes in periodontal animals in experimental osteoporosis were local manifestations of the general condition of the body that are typical of acute hypoxia mixed character. It was found that experimental osteoporosis in periodontal develop processes accompanied by acute circulatory disorders, which worsen the conditions of metabolism, which ultimately leads to destructive changes of argyrophilic and collagen fibrils, as well as individual nerve fibers. Studies have shown that these effects are reversible, and after 120 days to the fore the phenomenon of compensation in periodontal starting to recover basic histological structure. Prolonged hypoxia, as the main link in the pathogenesis of degenerative and inflammatory of forms of periodontal disease may be modified by the proven of efficiency pharmacological means. The detected changes at the osteoporosis models can be the basis for further study of the role of autologous mesenchymal stem cells and materials-matrices of various origins in optimizing the osseointegration process.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
N. I Bykova
Department of pediatric dentistry, orthodontics and oral and maxillofacial surgery Kuban state medical University, Russian Ministry of health
Author for correspondence.
Email: info@eco-vector.com
Russia, 355063, Krasnodar
T. L Kobylkina
Department of dentistry Stavropol State Medical University Ministry of health of Russia
Email: kafedrastom@yandex.ru
Russia, 355017, Stavropol
V. A Grigoryan
Department of dentistry Stavropol State Medical University Ministry of health of Russia
Email: info@eco-vector.com
Russia, 355017, Stavropol
A. A Adamchik
Department of therapeutic dentistry Kuban state medical University, Russian Ministry of health
Email: info@eco-vector.com
Russia, 355063, Krasnodar
A. V Arutyunov
Department of therapeutic dentistry Kuban state medical University, Russian Ministry of health
Email: info@eco-vector.com
Russia, 355063, Krasnodar
References
- Будзинский Н.Э., Сирак С.В., Максимова Е.М., Сирак А.Г. Определение антимикробной активности мирамистина, иммобилизованного на композиционном полисорбе, на микрофлору корневых каналов при остром и обострившемся хроническом периодонтите и процесс остеофикации в эксперименте на животных. Фундаментальные исследования. 2013; 7 (3): 518-22.
- Сирак А.Г., Щетинин Е.В., Сирак С.В., Арутюнов А.В., Паразян Л.А., Игнатиади О.Н., Дыгов Э.А. Разработка и экспериментальное использование новых стоматологических материалов для стимулирования репаративного остеогенеза при лечении деструктивных форм хронического периодонтита. Медицинский вестник Северного Кавказа. 2014; 9 (4): 332-6. doi: 10.14300/mnnc.2014.09093
- Сирак С.В., Щетинин Е.В., Слетов А.А. Субантральная аугментация пористым титаном в эксперименте и клинике. Стоматология. 2016; 95 (1): 55-8.
- Слетов А.А., Переверзев Р.В., Ибрагимов И.М., Кодзоков Б.А., Сирак С.В. Экспериментальное определение регенераторного потенциала клеток костного мозга. Стоматология для всех. 2012; 2: 29-31.
- Bendele A.M. Animal models of osteoarthritis in an era of molecular biology. J. Musculoskeletal Neuronal Interactions. 2002; 2 (6): 501-3.
- Eriksen E.F. Cellular mechanisms of bone remodeling. Reviews in Endocrine and Metabolic Disorders. 2010; 11 (4): 219-27. doi: 10.1007/s11154-010-9153-1
- Iwamoto J., Seki A., Matsuura M., Sato Y., Takeda T., Matsumoto H., Yeh J.K. Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys. Yonsei Med. J. 2009; 5093: 358-67. doi: 10.3349/ymj.2009.50.3.358
- Firsova I.V., Makedonova Iu.A., Mikhalchenko D.V., Poroiskii S.V., Sirak S.V. Clinical and experimental study of the regenerative features of oral mucosa under autohemotherapy. Res. J. Phar. Biol. Chemical Sci. 2015; 6: 1711-6.
- Lelovas P.P., Xanthos T.T., Thorma S.E., Lyritis G.P., Dontas I.A. The laboratory rat as an animal model for osteoporosis research. Comparative Medicine. 2008; 58 (5): 424-30.
- Miller P.D. Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis. Osteoporosis, Two-Volume Set. 2008: 1725-42. doi: 10.1016/B978-012370544-0.50076-8.
- Henriksen K., Bollerslev J., Everts V., Karsdal M.A.Osteoclast activity and subtypes as a function of physiology and pathology - Implications for future treatments of osteoporosis. Endocrine Reviews. 2011; 32 (1): 31-63. doi: 10.1210/er.2010-0006
- Grimm W.D., Plöger M., Schau I., Vukovic M.A., Shchetinin E.V., Akkalaev A.B., Arutunov A.V., Sirak S.V. Рrefabricated 3d allogenic bone block in conjunction with stem cell-containing subepithelial connective tissue graft for horizontal alveolar bone augmentation:a case report as proof of clinical study principles. Медицинский вестник Северного Кавказа. 2014; 9 (2): 175-8. doi: 10.14300/mnnc.2014.09050
- Grimm W.D., Dannan A., Giesenhagen B., Schau I., Varga G., Vukovic M.A., Sirak S.V. Тranslational research: palatal-derived ecto-mesenchymal stem cells from human palate: a new hope for alveolar bone and cranio-facial bone reconstruction. Int. J. Stem Cells. 2014; 7 (1): 23-9.
- Grimm W.D., Arnold W.A., Sirak S.W., Vukovich M.A., Videra D., Giesenhagen B. Сlinical, radiographic, and histological analyses after transplantation of crest-related palatal-derived ectomesenchymal stem cells (paldscs) for improving vertical alveolar bone augmentation in critical size alveolar defects. J. Clin. Periodontol. 2015; 42 (S17): 366b-6.
- Sirak S.V., Shchetinin E.V. Рrevention of complications in patients suffering from pathological mandibular fractures due to bisphosphonate-associated osteonecrosis. Res. J. Pharm. Biol. Chem. Sci. 2015; 6 (5): 1678-84.
- Sirak S.W., Entschladen F., Shchetinin E.W., Grimm W.D. Low-level laser irradiation (810 nm) with toluidinblue photosensitizer promotes proliferation and differentiation of human oral fibroblasts evaluated in vitro. J. Clin. Periodontol. 2015; 42 (S17): 328a-328.
- Weinstein R.S. Glucocorticoid-Induced Osteoporosis. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition, 2009: 267-72. doi: 10.1002/9780470623992.ch58.
![](/img/style/loading.gif)