Periodontology status and features local cytokine immunity in pregnant women with chronic generalized parodontitis in dynamics of gestational period

The aim of this work is to assess the condition ofperiodontal tissues and hygiene ofthe oral cavity, as well as local cytokine profile in women with chronic generalized periodontitis (present study included) easy and moderate severity in the dynamics of pregnancy. Material and methods. In the clinical group of 31 pregnant women from the present study included consistently for all three trimestrul pregnancy ELISA determined the concentration in oral fluid interleukins IL-1β, IL-4, IL-6, and tumor necrosis factor TNF-a, and then determine a causal relationship between cytokine level and course of dental diseases. Results. In the clinical group in the dynamics of the gestational period, the increase in concentrations of IL-1β, IL-4, IL-6 and TNF-a with a large gradient compared to the control group. In pregnant women with present study included moderate compared to the present study included patients with mild severity the content of IL-1β, IL-6 and TNF-a in saliva significantly increased, respectively, 39m2; 27,2 and 55,5% (p < 0,05), and the concentration of anti-inflammatory mediator IL-4 was decreased on average by 34,4% (p < 0,05). Conclusions. Increased levels ofproinflammatory mediators IL-1β, IL-6 and TNF-a in oralfluid ofpregnant women with present study included light and medium severity activates inflammatory and destructive processes that destroy the periodontium and thereby contributes to the progression of dental disease.