Metabolic disorders in chronic generalized periodontitis

The paper presents the results of a clinical study of the relationship of the mechanisms of endogenous intoxication and lipid peroxidation in the development of chronic generalized periodontitis in 26 patients aged 30 to 50 years, treated in the national dental clinic and dental clinic № 3, Saransk. It is shown thatfor patients with chronic generalized periodontitis is characterized by the formation of a syndrome of endogenous intoxication, as one of the most important components of the pathogenesis of this disease. Carried out the complex of therapeutic measures (basic therapy) suspends, but does not eliminates endotoxicosis. Confirmation of the presence of endotoxemia in chronic periodontitis on the background of basic therapy is to maintain blood plasma molecular products of lipid peroxidation, which identified and chemiluminescence test, and in the lipids of lipoproteins in the blood. Diagnosed with changes in indicators of free radical oxidation of lipids correlated with parameters reflecting the effects of endogenous intoxication (r=0,79-0,87), indicating that the relationship between endotoxemia and processes of lipid peroxidation, as the criteria for progression of chronic periodontitis. Performed study demonstrates the lack of desired positive results of traditional therapy for the correction of endogenous intoxication and processes of lipid peroxidation in patients with chronic periodontitis. This fact is the basis for the feasibility of developing new schemes pharmacotherapy of chronic periodontitis.

chronic generalized periodontitis, lipid peroxidation, endogenous intoxication