Comorbidity of periodontal diseases and atopic dermatitis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

BACKGROUND: The relationship between periodontal diseases and somatic pathology has been proven. Studies on the link between periodontal and atopic diseases are few, which determines the relevance of this study.

AIM: To characterize the relationship between inflammatory periodontal diseases and atopic dermatitis.

MATERIALS AND METHODS: Overall, 26,470 full-text publications from 2016 to 2023 on the research topic were found in the databases PubMed, Google Scholar, and eLIBRARY.RU.

RESULTS: An analysis of literature data was performed to study the relationship between inflammatory periodontal diseases and atopic dermatitis. On the one hand, the presence of oral pathology in patients with atopic diseases can lead to atopic disease worsening, and on the other hand, an atopic disease can contribute to the development of oral diseases. After conducting a literature search and applying the inclusion and exclusion criteria for the sample, complete overlap of the research topics was found in three publications. The data obtained were contradictory, as two publications established a direct connection between periodontitis and atopic dermatitis and one publication did not. In studies on the research topic on certain aspects, the possible mechanisms of comorbidity of periodontal and atopic diseases are characterized and assessments on the existence of a feedback or direct relationship between these pathologies are presented.

CONCLUSION: The periodontal status of patients with atopic dermatitis remains poorly understood, and evidence linking oral diseases to it is ambiguous. The presented studies relatively confirmed the direct connection between periodontal diseases and atopic dermatitis; however, the hygiene hypothesis, that is, there is an inverse relationship between periodontal diseases and atopic diseases, was not confirmed.

About the authors

Olga S. Donskaya

Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: olia.kafedra.psz@yandex.ru
ORCID iD: 0000-0002-3477-2987
SPIN-code: 1713-9441

MD, Cand. Sci. (Medicine)

Russian Federation, 6–8 L’va Tolstogo street, 197022 Saint Petersburg

Ekaterina I. Berdnikova

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: berdnikova.ekaterina.81@mail.ru
ORCID iD: 0009-0006-1842-0320
SPIN-code: 3111-4682

MD, Cand. Sci. (Medicine)

Russian Federation, 6–8 L’va Tolstogo street, 197022 Saint Petersburg

References

  1. Soldatov IK, Evdokimov VI, Grebnev GA. Genesis of scientific research directions in dentistry: on the materials of dissertation research. Russian Journal of Dentistry. 2023;27(1):71–78. EDN: GLCPHT doi: 10.17816/dent120029
  2. Soldatov IК, Juravleva LN, Tegza NV. Scientometric analysis of dissertation papers on pediatric dentistry in Russia. Russian Journal of Dentistry. 2023;27(6):571–580. EDN: ALVFZJ doi: 10.17816/dent624942
  3. Chaykovskaya IV, Maylyan EA, Soboleva AA, et al. The prevalence of periodontitis and its etiopathogenetic and clinical relationships with postmenopausal osteoporosis. Vestnik of Hygiene and Epidemiology. 2021;25(1):107–114. EDN: RMNTYV
  4. Sevryukov F, Malinina O, Yelina Yu. Peculiar features of morbidity of the population with disordes of the genitourinary sistem and diseases of the prostate gland, in particular, in the Russian Federation, in the Privolzhsky (Volga) Federal District, and in the Nizhni Novgorod Region. Social Aspects of Population Health. 2011;(6):8. EDN: OPGNQF
  5. Zachinyaeva AI, Ponomarev AA, Cimbalistov AV, Hapsirokova ZZ. Analysis of the prevalence of periodontitis of varying severity in patients with type i diabetes mellitus, depending on age and gender. The Dental Institute. 2023;(2);54–55. EDN: PPFWRR
  6. Kadyrov ZA, Faniev MV, Prokopiev YaV, et al. Reproductive health of the Russian population as a key factor of demographic dynamics. The Bulletin of Contemporary Clinical Medicine. 2022;15(5):100–106. EDN: FPJIAU doi: 10.20969/VSKM.2022.15(5).100-106
  7. Apolikhin OI, Sevrukov FA, Sorokin DA, et al. State and prognosis of the urogenital diseases morbidity in the adults of Nizhegorodsky Region. Experimental & Clinical Urology. 2012;(4):4–7. EDN: PLNQQD
  8. Sirak SV, Shchetinin EV, Bykova NI. Analysis of the effectiveness of anti-recursion therapy options for chronic generalized periodontitis: a multicenter prospective study. Medical News of North Caucasus. 2023;18(3):278–282. EDN: ULHKWU doi: 10.14300/mnnc.2023.18065
  9. Starcev VJu, Dudarev VA, Sevrjukov FA, Zabrodina NB. Economic aspects of treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia. Urologiia. 2019;(6):115–119. EDN: DBIZTQ doi: 10.18565/urology.2019.6.115-119
  10. Sevryukov FA, Malinina OYu. New organizational schemes of providing medical care to patients with benign hyperplasia of the prostate gland. Social Aspects of Population Health. 2012;(1):5. EDN: OVYASH
  11. Yelizova LA, Atrushkevich VG, Orekhova LYu. New classification of periodontal diseases. Periodontitis. Parodontologiya. 2021;26(1):80–82. EDN: ACQDQR
  12. Bhuyan R, Bhuyan SK, Mohanty JN, et al. Periodontitis and its inflammatory changes linked to various systemic diseases: a review of its underlying mechanisms. Biomedicines. 2022;10(10):2659. doi: 10.3390/biomedicines10102659
  13. Slazhneva ES, Atrushkevitch VG, Orekhova LYu, Loboda ES. Prevalence of periodontal diseases in patients with different body mass index. Parodontologiya. 2022;27(3):202–208. EDN: KLPVCI doi: 10.33925/1683-3759-2022-27-3-202-208
  14. Perugia C, Saraceno R, Ventura A, et al. Atopic dermatitis and dental manifestations. G Ital Dermatol Venereol. 2017;152(2):122–125. doi: 10.23736/S0392-0488.16.05224-X
  15. Lundmark A, Hu YOO, Huss M, et al. Identification of salivary microbiota and its association with host inflammatory mediators in periodontitis. Front Cell Infect Microbiol. 2019;(9):216. doi: 10.3389/fcimb.2019.00216
  16. Shi T, Jin Y, Miao Y, et al. IL-10 secreting B cells regulate periodontal immune response during periodontitis. Odontology. 2020;108(3):350–357. doi: 10.1007/s10266-019-00470-2
  17. Cardoso EM, Reis C, Manzanares-Céspedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. Postgrad Med. 2018;130(1):98–104. doi: 10.1080/00325481.2018.1396876
  18. Jain P, Hassan N, Khatoon K, et al. Periodontitis and Systemic disorder — an overview of relation and novel treatment modalities. Pharmaceutics. 2021;13(8):1175. doi: 10.3390/pharmaceutics13081175
  19. Xu J, Chang X, Zhang H, et al. Exosomes: a bridge of periodontitis and systemic diseases. Gene & Protein in Disease. 2022;1(2):99. doi: 10.36922/gpd.v1i2.99
  20. Wielento A, Lagosz-Cwik KB, Potempa J, Grabiec AM. The role of gingival fibroblasts in the pathogenesis of periodontitis. J Dent Res. 2023;102(5):489–496. doi: 10.1177/00220345231151921
  21. Deng J, Lu C, Zhao Q, et al. The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis. J Periodontal Res. 2022;57(2):246–255. doi: 10.1111/jre.12958
  22. Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426–440. doi: 10.1038/s41577-020-00488-6
  23. Duryagina LKh, Kolesnik VM, Degtyareva LA, et al. Some aspects of the course of periodontal diseases and diseases of mucous membrane of an oral cavity in combination with somatic pathology: a literature review. Crimean Journal of Internal Diseases. 2020;(1):43–48. EDN: XOUGJH
  24. Vasilenko VS, Antonova IN, Matveeva EV, et al. Association of inflammatory periodontal diseases with atherosclerotic cardiovascular diseases and arterial hypertension (review). Medicine: Theory and Practice. 2023;8(1):3–16. EDN: XIJGRH doi: 10.56871/MTP.2023.61.37.001
  25. Larvin H, Kang J, Aggarwal VR, et al. Periodontitis and risk of immune-mediated systemic conditions: a systematic review and meta analysis. Community Dent Oral Epidemiol. 2023;51(5):705–717. doi: 10.1111/cdoe.12812
  26. Jepsen S, Caton JG, Albandar JM, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;45 Suppl. 20:S219–S229. doi: 10.1111/jcpe.12951
  27. Bărgăoanu P, Temelie-Olinici D, Botez AE, et al. Atopic dermatitis: from molecular specificity of oral manifestations to clinical implications. Romanian Journal of Oral Rehabilitation. 2022;14(4):239–247.
  28. Pfaller B, José Yepes-Nuñez J, Agache I, et al. Biologicals in atopic disease in pregnancy: an EAACI position paper. Allergy. 2021;76(1):71–89. doi: 10.1111/all.14282
  29. Wong CY, Yeh KW, Huang JL, et al. Longitudinal analysis of total serum IgE levels with allergen sensitization and atopic diseases in early childhood. Sci Rep. 2020;10(1):21278. doi: 10.1038/s41598-020-78272-8
  30. Shim JS, Yang MS. Identification of oral symptoms associated with atopic dermatitis in adolescents: results from the Korea national representative survey 2009–2017. Sci Rep. 2020;10(1):19461. doi: 10.1038/s41598-020-76532-1
  31. Hill DA, Spergel JM. The atopic march: critical evidence and clinical relevance. Ann Allergy Asthma Immunol. 2018;120(2):131–137. Corrected and republished from: Ann Allergy Asthma Immunol. 2018;120(4):451. doi: 10.1016/j.anai.2017.10.037
  32. Sicherer SH, Warren CM, Dant C, et al. Food allergy from infancy through adulthood. J Allergy Clin Immunol Pract. 2020;8(6):1854–1864. doi: 10.1016/j.jaip.2020.02.010
  33. Rasheed Z, Zedan K, Saif GB, et al. Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E. Clin Mol Allergy. 2018;16:23. doi: 10.1186/s12948-018-0102-y
  34. Alsulami S, Aldoboke A, Nooh R, et al. Prevalence of asthma, allergic rhinitis, and atopic dermatitis and their association with oral health in Saudi Arabia. Cureus. 2023;15(4):e38061. doi: 10.7759/cureus.38061
  35. Polunina OS, Sarkisov KA, Falchari RA, Popov EA. Microcirculatory disorders of the mucosa of the oral cavity with periodontitis in patients with bronchial asthma. Uspehi sovremennoj nauki. 2017;(11):155–159. (In Russ). EDN: ZTDEJJ
  36. Arafa A, Aldahlawi S, Fathi A. Assessment of the oral health status of asthmatic children. Eur J Dent. 2017;11(3):357–363. doi: 10.4103/ejd.ejd_65_17
  37. Gani F, Caminati M, Bellavia F, et al. Oral health in asthmatic patients: a review: asthma and its therapy may impact on oral health. Clin Mol Allergy. 2020;18(1):22. doi: 10.1186/s12948-020-00137-2
  38. Shah PD, Badner VM, Moss KL. Association between asthma and periodontitis in the US adult population: a population-based observational epidemiological study. J Clin Periodontol. 2022;49(3):230–239. doi: 10.1111/jcpe.13579
  39. Wu Z, Xiao C, Chen F, et al. Pulmonary disease and periodontal health: a meta-analysis. Sleep Breath. 2022;26(4):1857–1868. doi: 10.1007/s11325-022-02577-3
  40. Moeintaghavi A, Akbari A, Rezaeetalab F. Association between periodontitis and periodontal indices in newly diagnosed bronchial asthma. J Adv Periodontol Implant Dent. 2022;14(2):97–103. doi: 10.34172/japid.2022.010
  41. Abdullaeva S. Comorbidity of chronic generalized periodontitis and food allergy. Dentistry. Aesthetics. Innovations. 2023;7(1):41–46. EDN: QLZSUI doi: 10.34883/PI.2023.7.1.004
  42. Sokolova TV, Davidenko MS, Saverskaya EN, Eltsova NV. The role of mycoses of the skin and mucous membranes in the chronicization of atopic dermatitis in adolescents (15–17 years old). Uspehi medicinskoj mikologii. 2018;(18):355–359. (In Russ). EDN: URJIHI
  43. Núñez Amin Dick T, Rocha Santos L, Carneiro S, et al. Investigation of oral atopic diseases: Correlation between geographic tongue and fungiform papillary glossitis. J Stomatol Oral Maxillofac Surg. 2021;122(3):283–288. doi: 10.1016/j.jormas.2020.05.025
  44. Hung SH, Tsai MC, Lin HC, Chung SD. Allergic rhinitis is associated with periodontitis: a population-based study. J Periodontol. 2016;87(7):749–755. doi: 10.1902/jop.2016.150539
  45. Wee JH, Park MW, Min C, et al. Poor oral health is associated with asthma, allergic rhinitis, and atopic dermatitis in Korean adolescents: a cross-sectional study. Medicine (Baltimore). 2020;99(31):e21534. doi: 10.1097/MD.0000000000021534
  46. Wee JH, Yoo DM, Byun SH, et al. Subjective oral health status in an adult Korean population with asthma or allergic rhinitis. Medicine (Baltimore). 2020;99(43):e22967. doi: 10.1097/MD.0000000000022967
  47. Kim EJ, Choi YK. Allergic rhinitis and periodontitis among Korean adults: results from a nationwide population-based study (2013–2015). BMC Ear Nose Throat Disord. 2018;18:12. doi: 10.1186/s12901-018-0062-3
  48. Kim S, Park B, Kong I, et al. Dental caries is negatively associated with allergic rhinitis, asthma and atopic dermatitis in children. B-ENT. 2017;13:265–270.
  49. Arbes SJ Jr, Matsui EC. Can oral pathogens influence allergic disease? J Allergy Clin Immunol. 2011;127(5):1119–1127. doi: 10.1016/j.jaci.2011.03.023
  50. Du M, Xu S, Qiu B, et al. Serum antibodies to periodontal pathogens are related to allergic symptoms. J Periodontol. 2023;94(2):204–216. doi: 10.1002/JPER.22-0346
  51. Macklis P, Adams K, Kaffenberger J, et al. The association between oral health and skin disease. The Journal of Clinical and Aesthetic Dermatology. 2020;13(6):48–53.
  52. Bansal V, Reddy KVG, Shrivastava S, et al. Oral health assessment in children aging 8–15 years with bronchial asthma using inhalation medication. Tzu Chi Med J. 2021;34(2):239–244. doi: 10.4103/tcmj.tcmj_74_21
  53. Bairappan S, Puranik MP, R SK. Impact of asthma and its medication on salivary characteristics and oral health in adolescents: a cross-sectional comparative study. Spec Care Dentist. 2020;40(3):227–237. doi: 10.1111/scd.12462
  54. Oliveira ADT, Sodré CS, Ferreira DC, et al. Oral aspects identified in atopic dermatitis patients: a literature review. Open Dent J. 2018;12:424–434. doi: 10.2174/1874210601812010424
  55. Smirnova J, Montgomery S, Lindberg M, et al. Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study. BMC Dermatol. 2020;20(1):23. doi: 10.1186/s12895-020-00117-8
  56. Valenzuela F, Chandia MA, Urrea GA, et al. Periodontitis in individuals with atopic dermatitis. Piel. 2021;36(4):218–223. (In Spanish). doi: 10.1016/j.piel.2020.06.005
  57. Tursas L, Ylipalosaari M, Sinikumpu SP, et al. Association between bleeding periodontal pockets and eczemas: results of the Northern Finland Birth Cohort 1966. J Clin Periodontol. 2022;49(6):591–598. doi: 10.1111/jcpe.13614

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Article selection methodology.

Download (132KB)
Indexing metadata

Copyright (c) 2024 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies