Analysis of the content of mineral elements in connective tissues in patients with bisphosphonate osteonecrosis

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Abstract

BACKGROUND: The presence of a large number of pathological studies and a significant amount of literature on high bone density in patients with bisphosphonate osteonecrosis determined the conduct of this study.

AIM: To monitor micro- and macronutrients in patients with bisphosphonate osteonecrosis of the jaws, to detail their role in the pathological process.

MATERIALS AND METHODS: In 184 patients with bisphosphonate necrosis, after sequestrectomy, the micro- and macronutrient composition of bone fragments removed from the lesion was analyzed.

RESULTS: Deviations from reference values were found in such elements as sulfur (S2-), chlorine (Cl-), potassium (K+), calcium (Ca2+), phosphorus (P3+). The dynamics of micro- and macronutrients correlated with the clinical picture of the pathological process under study and the number of sessions or courses of adjuvant therapy.

CONCLUSION: It is assumed that violations of cascade physiological reactions that develop as a result of violations of the mineral composition in the connective tissue are due to the pharmacokinetic properties of bisphosphonate preparations. The study of a number of micro- and macronutrients is predetermined by their role in the life and functional activity of amino acids, enzymatic systems, importance in the structure of cells and tissues.

About the authors

Kristina S. Gandylyan

Stavropol State Medical University

Email: gandilyanks@yandex.ru
ORCID iD: 0000-0001-8682-6986

cand. sci. (med.), professor

Russian Federation, Stavropol

Valeria A. Sletova

Pyatigorsk Medical and Pharmaceutical Institute — branch of the Volgograd State Medical University

Email: sl.valeria.al@yandex.ru
ORCID iD: 0000-0002-7026-3506

lecturer

Russian Federation, 11 Kalinina avenue, 357532 Pyatigorsk

Irina V. Gabbasova

Pyatigorsk Medical and Pharmaceutical Institute — branch of the Volgograd State Medical University

Email: viktor.gabbasov.56@mail.ru

lecturer

Russian Federation, 11 Kalinina avenue, 357532 Pyatigorsk

Asiyat M. Idrisova

Dagestan State Medical Academy

Email: idrisova050505@mail.ru

assistant lecturer

Russian Federation, Dagestan

Iman S. Elsieva

Pyatigorsk Medical and Pharmaceutical Institute — branch of the Volgograd State Medical University

Email: iman.elsiyeva@bk.ru
ORCID iD: 0009-0009-5493-3424

student

Russian Federation, 11 Kalinina avenue, 357532 Pyatigorsk

Alexandr A. Sletov

Pyatigorsk Medical and Pharmaceutical Institute — branch of the Volgograd State Medical University

Author for correspondence.
Email: dr.sletov-aleksandr@yandex.ru
ORCID iD: 0000-0001-5183-9330

md, dr. sci. (med.), professor, head of the department

Russian Federation, 11 Kalinina avenue, 357532 Pyatigorsk

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