ASSOCIATION OF POLYMORPHIC LOCI HSP1A GENES WITH THE DEVELOPMENT OF CHRONIC MERCURY INTOXICATION


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The present study investigated the association between polymorphic variants of HSP1A genes (HSP70 gene family) and chronic mercury intoxication (CMI) development in 87 workers of caustic soda production plant, who have been chronically exposed to mercury vapor. The polymorphic loci HSPA1B (+1267A/G и +2074G/C) and HSP1AL (+2437T/C) were studied. Genotyping was performed using PCR-RFLP and logistic regression analysis was used for three genetic models for the investigation of the required associations. We found that frequency of genotype GG HSPA1B (+1267A/G) in group of patients with CMI (n = 45) was higher (p = 0.003) compared with the group of workers without the disease (n = 42). Recessive genetic model found a strong association of the homozygous GG genotype for rare allele with the development of CMI (OR = 13.26, p = 0.001). The obtained associations indicate that the HSPA1 could be important in mechanisms of CMI development and progression and help to develop the criteria for assessing individual's susceptibility to its development.

作者简介

Yu Chernyak

ast-Siberian Institute of Medical and Ecological Research

Email: yuri_chernyak@hotmail.com
доктор биологических наук, старший научный сотрудник, ведущий научный сотрудник лаборатории иммуно-биохимических и молекулярно-генетических исследований Angarsk, Russia

参考

  1. Безгодов И. В., Лаптев И. Ф., Рогалева В. В., Ефимова Н. В., Андреева О. К. Оценка ртутной опасности на предприятиях химической промышленности Иркутской области // Бюллетень ВСНЦ СО РАМН. 2005. № 2 (40). С. 70-74.
  2. Лахман О. Л., Катаманова Е. В., Константинова Т. Н., Шевченко О. И., Мещерягин В. А., Андреева О. И., Русанова Д. В., Судакова Н. Г. Современные подходы к классификации профессиональной интоксикации ртутью // Экология человека. 2009. № 12. С. 22-27.
  3. Шаяхметов С. Ф., Лисецкая Л. Г., Мещакова Н. М. Оценка загрязнения воздуха рабочей зоны ртутью и содержания ее в биосредах работников производства каустика и хлора // Бюллетень ВСНЦ СО РАМН. 2010. № 4 (74). С. 59-63.
  4. Bast-Pettersen R., Ellingsen D. G., Efskind J., Jordskogen R., Thomassen Y. A neurobehavioral study of chloralkali workers after the cessation of exposure to mercury vapor // Neurotoxicology. 2005. N 3. P. 427-437.
  5. Cavanagh J. B. Long term persistence of mercury in the brain // British Journal of Industrial Medicine. 1988. N 10. P 649-651.
  6. Concise international chemical assessment document 50. Elemental mercury and inorganic mercury compounds: human health aspects. WHO, Geneva, Switzerland, 2003. URL: http://www.who.int/ipcs/publications/cicad/en/cicad50.pdf (дата обращения: 25.05.2015).
  7. Kampinga H. H., Hageman J., Vos M. J., Kubota H., Tanquay R. M., Bruford E.A., Cheetham M. E., Chen B., Hightower L. E. Guidelines for the nomenclature of the human heat shock proteins // Cell Stress Chaperones. 2009. N 1. P. 105-111.
  8. Li J. X., Tang B. P., Sun H. P., Feng M., Cheng Z. H., Niu W. Q. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity // Cell Stress Chaperones. 2009. N 4. P. 355-362.
  9. Miller K., Ochudlo S., Opala G., Smolicha W., Siuda J. Parkinsonism in chronic occupational metallic mercury intoxication // Neurologia i Neurochirurgia Polska. 2003. N 5. P. 31-38. URL: http://www.ncbi.nlm.nih.gov/ pubmed/15098329 (дата обращения: 18.06.2015).
  10. Singh R., Kolvraa S., Bross P., Jensen U. B., Gregersen N., Tan Q., Knudsen C., Rattan S. I. Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes // Cell Stress Chaperones. 2006. N 3. P 208-215.
  11. Temple S. E., Cheong K. Y., Ardlie K. G., Sayer D., Waterer G. W. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B // Intensive Care Medicine. 2004. N 9. P 1761 - 1767.
  12. Turturici G., Sconzo G., Geraci F. Hsp70 and its molecular role in nervous system diseases // Biochemistry Research International. 2011. URL: http://dx.doi. org/10.1 155/201 1/618127 (дата обращения: 14.02.2015).
  13. Vos M. J., Hageman J., Carra S., Kampinga H. H. Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families // Biochemistry. 2008. N 27. P 7001-701 1.
  14. Wastensson G., Lamoureux D., Sällsten G., Beuter A., Barregârd L. Quantitative assessment of neuromotor function in workers with current low exposure to mercury vapor // Neurotoxicology. 2008. N 4. P. 596-604.
  15. Wu Y. R., Wang C. K., Chen C. M., Hsu Y., Lin S. J., Lin Y. Y., Fung H. C., Chang K. H., Lee-Chen G. J. Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson’s disease // Human Genetics. 2004. N 3. P. 236-241.

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