Нарушения белкового профиля человека в условиях воздействия тяжелых металлов


Цитировать

Полный текст

Аннотация

В обзоре рассмотрено влияние воздействия наиболее распространённых тяжёлых металлов (свинец, хром, кадмий, марганец, никель, ванадий), загрязняющих объекты среды обитания и являющихся фактором риска развития различных нарушений состояния здоровья, в том числе обмена веществ, на изменение белкового профиля организма человека.

Об авторах

Марина Александровна Землянова

Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения, г. Пермь

Email: zem@fcrisk.ru
доктор медицинских наук, зав. отделом биохимических и цитогенетических методов диагностики

А В Тарантин

Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения, г. Пермь

Список литературы

  1. Авцын А. П., Жаворонков А. А., Риш М. А., Строчкова Л. С. Микроэлементозы человека. Этиология, классификация, органопатология. М.: Медицина, 1991. 485 с.
  2. Токсикологическая химия. Аналитическая токсикология: учебник / под. ред. Р У. Хабриева, Н. И. Калетиной. М.: ГОЭТАР-Медиа, 2010. 752 с.
  3. Alexander B. H., Rabinowitz M., Smith D. Bone lead as abiological markers in epidemiologic studies of chronic toxicity: conceptual paradigms // Environ. Health Perspect. 1998. Vol. 106. P 108.
  4. Anderson R. A. Chromium as an essential nutrient for humans // Regulatory Toxicol. Pharmacol. 1997. Vol. 26. P. S35-S41.
  5. Boscolo P., Sabbioni E., Andreassi P., di Giacomo F., Giaccio M., di Gioacchino M. Immune parameters and blood and urine trace elements in nonallergic and nickel-sensitised humans. In: Collery P, Bratter P, Negretti de Bratter V, Khassanova L., Etienne J.-C., editors // Metal ions in biology and medicine, vol. 5. Paris: J ohn Libbey Eurotext, 1998. P. 545-555.
  6. Chen J. Y., Tsao G., Zhao Q., Zheng W. Differential cytotoxicity of Mn (II) and Mn (III): special reference to mitochondrial [Fe S] containing enzymes // Toxicol. Appl. Pharmacol. 2001. Vol. 175. P 160-168.
  7. Choi C. J., Anantharam V., Martin D. P., Nicholson E. M., Richt J. A., Kanthasamy A., et al. Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease // Toxicol. Sci. 2010. Vol. 115. P. 535-546.
  8. Colombo M., Hamelin C., Kouassi E., Fournier M., Bernier J. Differential effects of mercury, lead, and cadmium on IL-2 production by Jurkat T cells // Clin. Immunol. 2004. Vol. 111. P 311-322.
  9. Ding M., Li J. J., Leonard S. S., Ye J. P., Shi X., Colburn N. H., Castranova V., Vallyathan V. Vanadate-induced activation of activate or protein-1 role of reactive oxygen species // Carcinogenesis. 1999. Vol. 20. P 663-668.
  10. Douglas M. Templeton, Ying Liu. Multiple roles of cadmium in cell death and survival // Chemico-Biological Interactions. 2010. Vol. 188. P. 267-275.
  11. Godfrey M. E., Wojcik D. P., Krone C. A. Apolipoprotein E genotyping as a potential biomarker for mercury neurotoxicity // J. Alzheimers Dis. 2003. Vol. 3. P. 189-195.
  12. Goebeler M., Meinardus-Hager G., Roth J., Goerdt S., Sorg C. Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells // J. Invest. Dermatol. 1993. Vol. 100. P. 759-765.
  13. Goebeler M., Roth J., Brocker E. B., Sorg C., Schulze-Osthoff K. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt // J. Immunol. 1995. Vol. 155. P. 2459-2467.
  14. Graven K. K., McDonald R. J., Farber H. W. Hypoxia regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase // Am. J. Physiol. 1998. Vol. 43. P. 347-355.
  15. Ho V. T., Bunn H. F. Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a hemeprotein // Biochem. Biophys. Res. Commun. 1996. Vol. 223. P. 175-180.
  16. Hopfer S. M., Sunderman F. W. Jr., Fredrickson T. N., Morse E. E. Increased serum erythropoietin activity in rats following intrarenal injection of nickel subsulfide // Res. Commun. Chem. Pathol. Pharmacol. 1979. Vol. 23(1). P. 155-170.
  17. Horak E., Zygowicz E. R., Tarabishy R., Mitchell J. M., Sunderman F. W. Jr. Effects of nickel chloride and nickel carbonyl upon glucose metabolism in rats // Ann. Clin. Lab. Sci. 1978. Vol. 8(6). P. 476-482.
  18. Huang C., Zhang Z., Ding M., Li J., Ye J., Leonard S. S., Shen H. M., Butterworth L., Lu Y., Costa M., Rojanasakul Y., Castranova V., Vallyathan V., Shi X. Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis // J. Biol. Chem. 2000. Vol. 275. P. 32516-32522.
  19. Huang C., Ding M., Li J., Leonard S. S., Rojanasakul Y., Castranova V., Vallyathan V., Ju G., Shi X. Vanadium-induced nuclear factor of activated T cells activation through hydrogen peroxide // J. Biol. Chem. 2001. Vol. 276. P. 22397-22403.
  20. Huang L. E., Gu J., Schau M., Bunn H. F. Regulation of hypoxia-dependent inducible factor 1 alpha is mediated by an O2 degradation domain via the ubiquitin-proteasome pathway // Proc. Natl. Acad. Sci. USA. 1998. Vol. 95. P. 7987-7992.
  21. Iyer N. V., Kotc L. E., Agani F., et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 // Genes 2 Dev. 1998. Vol. 12. P. 149-162.
  22. Jannetto P. J., Antholine W E., Myers C. R. Cytochrome b(5) plays a key role in human microsomal chromium (VI) reduction // Toxicol. 2001. Vol. 159. P. 119-133.
  23. Jin T., Nordberg M., Frech W., Dumont X., Bernard A., Ye T., Kong Q., Wang Z., Li P., Lundstrom N.-G., Li Y., Nordberg G. F. Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (Chi-naCad) // Biometals. 2002. Vol. 15. P. 397-410.
  24. Kapsenberg M. L., Van der Pouw-Kraan T., Stiekema F. E., Schootemeijer A., Bos J. D. Direct and indirect nickel-specific stimulation of T-lymphocytes from patients with allergic contact dermatitis to nickel // Eur. J. Immunol. 1988. Vol. 18(7). P. 977-982.
  25. Kouzarides T. Transcriptional control by the retinoblastoma protein // Semin. Cancer Biol. 1995. Vol. 6. P. 91-98.
  26. Latchoumycandane C., Anantharam V., Kitazawa M., Yang Y. J., Kanthasamy A., Kanthasamy A. G. Proteinkinase C is a key downstream mediator of manganese-induced apopotosis in Dopaminergic Neuronal Cells // J. Pharmacol. Exp. Therapeutics. 2005. Vol. 313. P. 46-55.
  27. Lauwerys R. R., Bernard A. M., Buchet J. P., Roels H. A. Cadium: exposure markers as predictors of nephrotoxic effects // Clin. Chem. 1994. Vol. 40. P. 1391 - 1394.
  28. Lee W. H., Bookstein R., Lee E. Y. Studies on the human retinoblastoma susceptibility gene // J. Cell. Biochem. 1988. Vol. 38 (3). P. 213-227.
  29. Lu L., Zhang L. L., Li G. J., Guo W., Liang W., Zheng W. Alteration of serum concentrations of manganese, iron, ferritin, and transferitin receptor following exposure to welding fumes among career welders // Neurotoxicology. 2005. Vol. 26. P. 257-265.
  30. Maehle L., Metcalf R. A., Ryberg D., Bennett W. P., Harris C. C., Haugen A. Altered p53 gene structure and expression in human epithelial cells after exposure to nickel // Cancer. Res. 1992. Vol. 52. P. 218-221.
  31. Moriguchi J., Ezaki T., Tsukahara T., Furuki K., Fukui Y., Okamoto S., Ukai H., Sakurai H., Ikeda M. Alpha 1-microglobulin as a promising marker of cadmium-induced tubular dysfunction, possibly better than beta2-microglobulin // Toxicol. Lett. 2004. Vol. 148. P. 11-20.
  32. Nag D., Jaffery F. N., Viswanathan P. N. Clinical and biochemical screening tests for identification of high risk groups. In: Richardson, M. L. (Ed.) // Risk Reduction. Chemicals and Energy in to the 21st Century. Taylor & Francis, London, UK, 1996. P. 285-302.
  33. Namiki A., Brogi E., Kearney M., et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells // J. Biol. Chem. 1995. Vol. 270. P. 31 189-31 195.
  34. Oda T., Akaike T., Hamamoto T., SuzukiF., Hirano T., Maeda H. Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD // Science. 1989. Vol. 244. P. 974-976.
  35. Onalaja A. O., Claudio L. Genetic susceptibility to lead poisoning // Environ. Health Perspect. 2000. Vol. 108 (Suppl. 1). P. 23-28.
  36. Pandey S. K., Theberge J. F., Bernier M., Srivastava A. K. Phosphatidylinositol 3-kinase requirement inactivation of the ras/c-raf-l/MEK/ERK and p70 (s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate // Biochemistry. 1999. Vol. 38. P. 14667-14675.
  37. Poonam Kakkar, Farhat N. Jaffery. Biological markers for metal toxicity // Environmental Toxicology and Pharmacology. 2005. Vol. 19 (2). P. 335-349.
  38. Rani A. S., Qu D., Sidhu M. K., et al. Transformation of immortal, non-tumorigenic osteoblast-like human osteosarcoma cells to the tumorigenic phenotype by nickel sulfate // Carcinogenesis. 1993. Vol. 14. P. 947-953.
  39. Ray R. S., Ghosh B., Rana A., Chatterjee M. Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: chemopreventive activity of vanadium in vivo and in vitro // Int. J. Cancer. 2007. Vol. 120. P. 13-23.
  40. Romano J. W., Ehrhart J. C., Duthu A., Kim C. M., Appella E., May P. Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line // Oncogene. 1989. Vol. 4. P. 1483-1488.
  41. Sakai T. Biomarkers of lead exposure // Ind. Health. 2000. Vol. 38. P. 127-142.
  42. Salnikow K., Wang S., Costa M. Induction of activating transcription factor I by nickel and its role as a negative regulator of thrombospondin I gene expression // Cancer Res. 1997. Vol. 57. P. 5060-5066.
  43. Salnikow K., An W. G., Melillo G., Blagosklonny M. V., Costa M. Nickel-induced transformation shifts the balance between HIF-1 a and p53 transcription factors // Carcinogenesis. 1999. Vol. 20. P. 1819-1823.
  44. Salnikow K., Blagosklonny M., Ryan H., Johnson R., Costa M. Carcinogenic nickel induces genes involved with hypoxic stress // Cancer Res. 2000. Vol. 60. P. 38-41.
  45. Semenza G. L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1 // Annu. Rev. Cell. Dev. Biol. 1999. Vol. 15. P. 551-578.
  46. Shim H., Dolde C., Lewis B. C., et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth // Proc. Natl. Acad. Sci. USA. 1997. Vol. 94. P. 6658-6663.
  47. Sian J., Dexter D. T., Lees A. J., Daniel S., Agid Y., Javoy-Agid F., et.al. Alterations in glutathione levels in Parkinsons disease and other neurodegenerative disorders affecting basal ganglia // Ann. Neurol. 1994. Vol. 36. P. 356-361.
  48. Singhal R. K., Anderson M. E., Meister A. Glutathione, a first line of defense against cadmium toxicity // FASEB J. 1987. Vol. 1. P. 220-223.
  49. Sloot W. N., Korf J, Koster J. F., DeWit L. E. A., Gramsbergen J. B. P. Manganese-induced hydroxyl radical formation in rat striatum is not attenuated by dopamine depletion or iron chelation in vivo // Exp. Nurol. 1996. Vol. 138. P. 236-245.
  50. Smargiassi A., Mutti A. Peripheral biomarkers and exposure to manganese // Neurotoxicology. 1999. Vol. 20. P. 401-406.
  51. Takeda A. Manganese action in brain function // Brain. Res. Rev. 2003. Vol. 41. P. 79-87.
  52. Valko M., Rhodes C. J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer // Chem. Biol. Interact. 2006. Vol. 160. P. 1-40.
  53. Warburg O. On respiratory impairment in cancer cells // Science. 1956. Vol. 123. P. 309-314.
  54. Zheng W., Ren S., Graziano J.H. Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity. // Brain Res. 1998. Vol. 799. P. 334-342.
  55. Zheng W., Zhao Q., Slavkovich V., Aschner M., Graziano J. H. Alteration of iron homeostasis following chronic exposure to manganese in rats // Brain Res. 1999. Vol. 833. P. 125-132.
  56. Zhitkovich A., Voitkun V., Kluz T., Costa M. Utilization of DNA-protein crosslinks as a biomarker of chromium exposure // Environ. Health Perspect. 1998. Vol. 106. P. 969-973.
  57. Zhou D., Salnikow K., Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds // Cancer Res. 1998. Vol. 58. P. 2182-2189.

© Землянова М.А., Тарантин А.В., 2012

Creative Commons License
Эта статья доступна по лицензии Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах