Email this article POTENTIAL DANGER OF NANOSIZED POWDER BLUE TO HUMAN HEALTH
- Authors: Zemlyanova MA1,2,3, Tiunova AI2, Stepankov MS1,2, Ivanova AS2
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Affiliations:
- Federal Budget Science Institution "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
- Federal State Educational Institution of Higher Education "Perm State National Research University"
- Federal State Educational Institution of Higher Education "Perm National Research Polytechnic University"
- Issue: Vol 25, No 1 (2018)
- Pages: 36-40
- Section: Articles
- URL: https://journals.rcsi.science/1728-0869/article/view/16730
- DOI: https://doi.org/10.33396/1728-0869-2018-1-36-40
- ID: 16730
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Abstract
The data analysis presented in the studies of leading Russian and foreign centers on physico-chemical, molecular and biological, cytological and toxicological characteristics of nanosized powder blue has been done. Generalization of the information received and evaluation of potentially hazardous substances has shown that nanodispersed powder blue has a high degree of potential danger to human health. Powder blue nanoparticles have a size in the range of 41.2-77.9 nm, preferably of spherical shape, are hydrophobical, potentially high reactive. They have the ability to intracellular generation of reactive oxygen species causing the oxidative stress (particularly oxidative damage to proteins and indirect damage to DNA). They are able to DNA direct damage, having a dose and time-dependent character. They interact with the cell membrane, causing it damage (cytotoxicity), as evidenced by the decrease in mitochondrial activity, LDH release from cells, and fall of cells viability. A significant induction of chromosome aberrations is typical for powder blue nanoparticles. They cause a disturbance in proteomic and metabolomic profile, increase antioxidant enzyme of gene expression of HO-1, the production of cytokines MCP-1 and IL-8. They have possibly carcinogenic activity to humans, due to an increase in the level of intracellular reactive oxygen species formation, signaling cascades, damage to macromolecules - proteins and DNA.
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##article.viewOnOriginalSite##About the authors
M A Zemlyanova
Federal Budget Science Institution "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"; Federal State Educational Institution of Higher Education "Perm State National Research University"; Federal State Educational Institution of Higher Education "Perm National Research Polytechnic University"
Email: zem@fcrisk.ru
доктор медицинских наук, зав. отделом биохимических и цитогенетических методов диагностики; профессор кафедры экологии человека и безопасности жизнедеятельности; профессор кафедры охрана окружающей среды 614045, г. Пермь, ул. Монастырская, д. 82
A I Tiunova
Federal State Educational Institution of Higher Education "Perm State National Research University"г. Пермь
M S Stepankov
Federal Budget Science Institution "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"; Federal State Educational Institution of Higher Education "Perm State National Research University"г. Пермь
A S Ivanova
Federal State Educational Institution of Higher Education "Perm State National Research University"г. Пермь
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