Elemental imbalance in children with cerebral palsy (spastic diplegia)
- Authors: Larionova T.K.1, Daukaev R.A.1, Shaikhlislamova E.R.1, Larionova A.N.2, Aukhadieva E.A.1, Allayarova G.R.1, Adieva G.F.1, Zelenkovskaya E.E.1
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Affiliations:
- Ufa Research Institute of Occupational Health and Human Ecology
- Research and Clinical Center of Pediatric Psychoneurology
- Issue: Vol 31, No 11 (2024)
- Pages: 829-837
- Section: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/1728-0869/article/view/314558
- DOI: https://doi.org/10.17816/humeco643109
- EDN: https://elibrary.ru/ECFAPG
- ID: 314558
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Abstract
BACKGROUND: The risk of developing various disorders in children, including nervous system diseases, is often associated with impaired mineral metabolism, as macro- and microelements play a critical role in the functioning of both the central and autonomic nervous systems. Elemental imbalance in children may result from intrauterine developmental anomalies or from environmental exposure.
AIM: To analyze and assess the elemental composition of hair in children with cerebral palsy (spastic diplegia).
MATERIALS AND METHODS: A selective cohort study was conducted involving 93 children aged 3 to 6 years. The participants were divided into two groups: the main group, consisting of children diagnosed with cerebral palsy (spastic diplegia), and the control group. To assess elemental status, 14 chemical elements were measured in hair samples using atomic absorption spectrometry.
RESULTS: Elemental homeostasis in children diagnosed with cerebral palsy was found to be disrupted with respect to both essential and conditionally essential elements, as well as toxic ones. In the hair of children in the main group, significantly elevated levels (p < 0.05) of manganese, chromium, nickel, and lead were observed compared to the upper reference limit and the control group. At the same time, a significant decrease in selenium concentration was noted, relative to both the lower reference limit and the control group (by a factor of 46 and 20, respectively; p < 0.05).
CONCLUSION: Study of the elemental composition of hair may serve as an additional tool in the diagnosis of nervous system disorders in children and in guiding supplemental pharmacologic correction of mineral metabolism.
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##article.viewOnOriginalSite##About the authors
Tatiana K. Larionova
Ufa Research Institute of Occupational Health and Human Ecology
Author for correspondence.
Email: larionovatk@yandex.ru
ORCID iD: 0000-0001-9754-4685
SPIN-code: 5305-0589
Cand. Sci (Biology), Associate Professor
Russian Federation, UfaRustem A. Daukaev
Ufa Research Institute of Occupational Health and Human Ecology
Email: ufa.lab@yandex.ru
ORCID iD: 0000-0002-0421-4802
SPIN-code: 4086-7132
Cand. Sci (Biology)
Russian Federation, UfaElmira R. Shaikhlislamova
Ufa Research Institute of Occupational Health and Human Ecology
Email: shajkh.ehlmira@yandex.ru
ORCID iD: 0000-0002-6127-7703
SPIN-code: 1041-3862
MD, Cand. Sci. (Medicine)
Russian Federation, UfaAnna N. Larionova
Research and Clinical Center of Pediatric Psychoneurology
Email: annalario21@yandex.ru
ORCID iD: 0000-0001-9652-4236
SPIN-code: 8038-6346
Russian Federation, Moscow
Elvira A. Aukhadieva
Ufa Research Institute of Occupational Health and Human Ecology
Email: ufa.lab@yandex.ru
ORCID iD: 0000-0002-6793-6992
SPIN-code: 9475-1793
Russian Federation, Ufa
Guzel R. Allayarova
Ufa Research Institute of Occupational Health and Human Ecology
Email: ufa.lab@yandex.ru
ORCID iD: 0000-0003-0838-3598
SPIN-code: 3704-1010
Cand. Sci (Biology)
Russian Federation, UfaGyuzeliya F. Adieva
Ufa Research Institute of Occupational Health and Human Ecology
Email: ufa.lab@yandex.ru
ORCID iD: 0000-0003-2377-3471
SPIN-code: 3805-1755
Cand. Sci (Biology)
Russian Federation, UfaEvgenya E. Zelenkovskaya
Ufa Research Institute of Occupational Health and Human Ecology
Email: ufa.lab@yandex.ru
ORCID iD: 0000-0001-7682-2703
SPIN-code: 4662-3255
Russian Federation, Ufa
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