北极地区女性的细胞免疫反应
- 作者: Morozova O.S.1, Shchegoleva L.S.1, Shashkova E.Y.1, Filippova O.Е.1
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隶属关系:
- Federal Research Center for Comprehensive Study of the Arctic named after Academician N.P. Laverov
- 期: 卷 31, 编号 6 (2024)
- 页面: 447-455
- 栏目: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/1728-0869/article/view/314520
- DOI: https://doi.org/10.17816/humeco629203
- ID: 314520
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详细
背景。北极地区的不利气候和生态条件会导致机体免疫状态的改变,降低对病原微生物的整体抵抗力,并可能引发多种超敏反应和自身免疫敏感化。在免疫系统的形成和发育过程中,这些变化可能导致儿童生长迟缓,而在成年人中则可能加速早衰。
研究目的。评估居住在俄罗斯极北地区女性的外周血淋巴细胞表型分布及中性粒细胞吞噬活性。
材料与方法。本研究分析了居住于俄罗斯联邦极北地区(阿尔汉格尔斯克州皮涅加镇)的60名健康女性的免疫状态。受试者的平均年龄为47.76±0.94 岁。淋巴细胞表型检测:采用间接免疫过氧化物酶法,使用单克隆抗体测定外周血中CD3+、CD5+、CD8+、CD10+、CD16+、CD71+、HLA-DR+ 细胞的比例。中性粒细胞吞噬活性评估:采用乳胶颗粒吞噬实验,计算吞噬活性(%),并根据吞噬指数(每100个中性粒细胞吞噬的乳胶颗粒数)评估吞噬强度。统计分析:免疫学参数的描述性统计(均值 ± 标准误)。Spearman 秩相关系数用于非参数相关性分析。免疫参数失衡的比例基于异常浓度(高于或低于生理范围)的发生频率计算。数据分析使用 Statistica 10.0 和 Microsoft Excel 2010 进行处理。
结果。研究发现,受试者的细胞免疫系统处于应激状态,表现为:CD3+T淋巴细胞(95.00±1.61%)和CD5+T细胞(96.66±1.63%)活性降低;细胞毒性T细胞(CD8+)(53.33±1.20%)和自然杀伤细胞(CD16+)(48.33±1.14%)数量增加。这一免疫模式可能提示机体的免疫储备能力下降。此外,20.00±0.73%的受试者表现出中性粒细胞吞噬活性降低;21.66±0.77%的受试者CD10+细胞水平升高。
结论。T 淋巴细胞活性不足,同时细胞毒性 T 细胞和自然杀伤细胞数量增加,表明免疫系统处于持续的紧张状态。 吞噬活性的降低与 CD10+细胞增殖水平升高相关,这可能进一步削弱免疫稳态的储备能力。
作者简介
Olga S. Morozova
Federal Research Center for Comprehensive Study of the Arctic named after Academician N.P. Laverov
编辑信件的主要联系方式.
Email: olia.morozow2011@yandex.ru
ORCID iD: 0000-0002-9587-2500
SPIN 代码: 2965-1478
Cand. Sci. (Biology)
俄罗斯联邦, ArkhangelskLyubov S. Shchegoleva
Federal Research Center for Comprehensive Study of the Arctic named after Academician N.P. Laverov
Email: shchegoleva60@mail.ru
ORCID iD: 0000-0003-4900-4021
SPIN 代码: 6859-2123
Dr. Sci. (Biology), Professor
俄罗斯联邦, ArkhangelskElizaveta Yu. Shashkova
Federal Research Center for Comprehensive Study of the Arctic named after Academician N.P. Laverov
Email: eli1255@ya.ru
ORCID iD: 0000-0002-1735-6690
SPIN 代码: 8137-0571
Cand. Sci. (Biology)
俄罗斯联邦, ArkhangelskOksana Е. Filippova
Federal Research Center for Comprehensive Study of the Arctic named after Academician N.P. Laverov
Email: oxana_filippova_85@mail.ru
ORCID iD: 0000-0001-6117-0562
SPIN 代码: 8507-7525
Cand. Sci. (Biology)
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