Maternal correlates of spontaneous preterm birth in Kazakhstan: a matched case-control study
- Authors: Oralkhan Z.1, Sarsenova L.1, Kopbayeva M.2, Tastambek K.1, Grjibovski A.M.1,3,4,5,2, Berdalinova A.1,3, Balmagambetova A.3, Zhurabekova G.1,3
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Affiliations:
- Al-Farabi Kazakh National University
- Asfendiyarov Kazakh National Medical University
- West Kazakhstan Marat Ospanov State Medical University
- Northern State Medical University
- Northern (Arctic) Federal University
- Issue: Vol 30, No 12 (2023)
- Pages: 901-908
- Section: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/1728-0869/article/view/262165
- DOI: https://doi.org/10.17816/humeco629001
- ID: 262165
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Abstract
BACKGROUND: Preterm birth (PTB) continues to be a persistent health issue that significantly impacts neonatal morbidity and mortality worldwide. In Kazakhstan, the prevalence of PTB is 7% making a substantial contribution to adverse health outcomes among infants. However, there is a lack of comprehensive research on the factors contributing to PTB in Kazakhstan.
AIM: To study maternal factors associated with spontaneous PTB among Kazakh women.
MATERIAL AND METHODS: A case control study was conducted in three major reproductive hospitals in Atyrau, Aktobe and Kyzylorda from October 2022 to January 2023. The sample consisted of 90 cases with singleton live spontaneous PTB and 180 controls with spontaneous full-term delivery. Bivariate associations between categorical variables were assessed by chi-squared tests. Independent variables with p <0.1 in the bivariate analysis were entered into a conditional logistic regression model. Odds ratios (OR) with 95% confidence intervals (CI) were calculated.
RESULTS: Maternal education, periodontitis, body mass index and a history of PTB in previous pregnancies were associated with PTB in bivariate analysis. In multivariable models, only prior PTB (OR=38.10; 95% CI: 8.34–142.00) and periodontal disease (OR=2.09; 95% CI: 1.15–3.80) were associated with an increased risk of extremely and very preterm births while higher education (OR=0.44; 95% CI: 0.19–0.98) and a history of PTB (OR=27.20; 95% CI: 5.38–137.00) were associated with moderate to late PTB.
CONCLUSION: Our results are in line with the international evidence on prior PTB being the most important determinant of PTB in the index pregnancy. Moreover, our findings on the associations with periodontal disease underline the importance of a targeted, individualized and interdisciplinary antenatal care to the reduction in the prevalence of PTB.
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##article.viewOnOriginalSite##About the authors
Zhibek Oralkhan
Al-Farabi Kazakh National University
Email: september_becca@hotmail.com
ORCID iD: 0000-0002-8884-6523
Scopus Author ID: 56892790400
MD
Kazakhstan, 71 al-Farabi Ave., Almaty, 050040Lazzat Sarsenova
Al-Farabi Kazakh National University
Email: lazzat.sarsenova@kaznu.kz
ORCID iD: 0000-0001-8643-0703
PhD
Kazakhstan, 71 al-Farabi Ave., Almaty, 050040Maira Kopbayeva
Asfendiyarov Kazakh National Medical University
Email: m_kopbay@mail.ru
ORCID iD: 0000-0002-7439-5573
MD, PhD, Professor
Kazakhstan, AlmatyKuanysh Tastambek
Al-Farabi Kazakh National University
Email: tastambeku@gmail.com
ORCID iD: 0000-0002-2338-8816
PhD
Kazakhstan, AlmatyAndrej M. Grjibovski
Al-Farabi Kazakh National University; West Kazakhstan Marat Ospanov State Medical University; Northern State Medical University; Northern (Arctic) Federal University; Asfendiyarov Kazakh National Medical University
Email: a.grjibovski@yandex.ru
ORCID iD: 0000-0002-5464-0498
SPIN-code: 5118-0081
MD, MPhil, PhD
Kazakhstan, Arkhangelsk; Arkhangelsk; Almaty; 71 al-Farabi Ave., Almaty, 050040; AktobeAkzhenis Berdalinova
Al-Farabi Kazakh National University; West Kazakhstan Marat Ospanov State Medical University
Email: berdalinova77@mail.ru
ORCID iD: 0000-0002-5735-9538
Kazakhstan, 71 al-Farabi Ave., Almaty, 050040; Aktobe
Aru Balmagambetova
West Kazakhstan Marat Ospanov State Medical University
Email: aru.b.84@mail.ru
ORCID iD: 0000-0003-1151-5651
PhD
Kazakhstan, AktobeGulmira Zhurabekova
Al-Farabi Kazakh National University; West Kazakhstan Marat Ospanov State Medical University
Author for correspondence.
Email: zhurabekova.gulmira@kaznu.kz
ORCID iD: 0000-0002-2166-3095
MD, PhD, Associated Professor
Kazakhstan, 71 al-Farabi Ave., Almaty, 050040; AktobeReferences
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