MODERN APPROACHES TO ASSESSMENT OF METABOLISM DISORDERS OF XENOBIOTICS DURING THEIR ADMINISTRATION INTO BODY FROM EXTERNAL ENVIRONMENT

Marina Aleksandrovna Zemlyanova; Землянова Марина Александровна; Yu V Kol'dibekova; Кольдибекова Ю В; M A Zemlyanova; Zemlyanova M A; Yu V Koldibekova; Koldibekova Yu V

doi:10.17816/humeco17449

MODERN APPROACHES TO ASSESSMENT OF METABOLISM DISORDERS OF XENOBIOTICS DURING THEIR ADMINISTRATION INTO BODY FROM EXTERNAL ENVIRONMENT

Authors: Zemlyanova M.A.¹, Kol'dibekova Y.V¹, Zemlyanova MA², Koldibekova Y.V²
Affiliations:
1. Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения
2. Federal Scientific Center for Medical and Preventive Health RiskManagement Technologies
Issue: Vol 19, No 8 (2012)
Pages: 8-14
Section: Articles
URL: https://journals.rcsi.science/1728-0869/article/view/17449
DOI: https://doi.org/10.17816/humeco17449
ID: 17449

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Abstract

In this review, there have been considered current approaches to identification and use of indicators that reflected xenobiotics metabolism disorders caused by, on the one hand, by genetically determined biochemical individuality and increased sensitivity of human body, on the other hand - by accumulation of them in body biological fluids during constant administration from external environment. The study of the basic components of enzyme systems that implement metabolism of xenobiotics, can detect abnormalities in the process of detoxification of chemicals, which makes it possible to adjust the main elements of the metabolic transformation of toxicants, and enzymatic detoxification system components considered as markers of metabolism of xenobiotics, due to increased individual sensitivity and stable flow of xenobiotics into the body from the environment.

Keywords

xenobiotics, metabolism, increased sensitivity, glutathione system, population health

About the authors

Marina Aleksandrovna Zemlyanova

Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения

Email: zem@fcrisk.ru <mailto:zem@fcrisk.ru>
доктор медицинских наук, зав. отделом биохимических и цитогенетических методов диагностикиТел. 8 (342) 236-39-30; Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения

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