CHOLESTEROL AND RISK OF ATHEROSCLEROSIS IN RURAL INDIGENOUS POPULATION OF REPUBLIC OF SAKHA (YAKUTIA)
- Authors: Klimova TM1, Fedorova VI1, Baltakhinova ME1, Krivoshapkin VG1
-
Affiliations:
- Research Institute of Health of North-Eastern Federal University named after M. K. Ammosov
- Issue: Vol 21, No 4 (2014)
- Pages: 22-27
- Section: Articles
- URL: https://journals.rcsi.science/1728-0869/article/view/17245
- DOI: https://doi.org/10.17816/humeco17245
- ID: 17245
Cite item
Full Text
Abstract
According to the results of the cross-sectional study of rural indigenous population of the Republic of Sakha (Yakutia), there has been studied the level of cholesterol and frequency of atherogenic changes of the lipid profile of the blood plasma. It has been found that in 35 % of the surveyed indigenous people, the level of cholesterol was 5.2 mmol/l or more, and in 10.8 % - 6.2 mmol/l or more. Among the persons with high cholesterol, atherogenic changes of the ratio of total cholesterol / HDL-C, LDL-C / HDL-C were observed in 19 % of the men and 8 % of the women (р = 0.014); logarithm (TRG / HDL-C ) - in 11 % of the men and women (p = 0.906). Thus, the high levels of the total cholesterol (5.2 mmol /l or more) in 80 % of the men and in 89% of the women was not accompanied by atherogenic changes in the lipid profile. This allows to consider the status of hypercholesterolemia in this population group in most of the cases as a manifestation of adaptive changes in lipid metabolism. The identified changes in atherogenic lipid profile were associated with presence of metabolic risk factors, what proves the need for determination of cholesterol in lipoprotein composition and a ratio of lipid fractions for choice of a right tactics for correction of the lipid risk factors.
Full Text
##article.viewOnOriginalSite##About the authors
T M Klimova
Research Institute of Health of North-Eastern Federal University named after M. K. Ammosov
Email: tklimova@rambler.ru
кандидат медицинских наук, руководитель Лаборатории контроля качества биомедицинских исследований
V I Fedorova
Research Institute of Health of North-Eastern Federal University named after M. K. Ammosov
M E Baltakhinova
Research Institute of Health of North-Eastern Federal University named after M. K. Ammosov
V G Krivoshapkin
Research Institute of Health of North-Eastern Federal University named after M. K. Ammosov
References
- Гырголькау Л. А., Щербакова Л. В., Иванова М. В. Содержание липидов в крови и частота дислипопротеинемий у коренных жителей Чукотки // Бюллетень СО РАМН. 2011. Т. 31, № 5. С. 79-83.
- Климов А. Н., Никульчева Н. Г. Обмен липидов и липопротеидов и его нарушения : руководство для врачей. СПб. : Питер Ком, 1999. C. 365.
- Климова Т. М., Федорова В. И., Балтахинова М. Е. Критерии ожирения для идентификации метаболических факторов риска у коренного сельского населения Якутии // Сибирский медицинский журнал (Иркутск). 2012. Т. 115, № 8. С. 110-113.
- Климова Т. М., Федорова В. И., Балтахинова М. Е., Кривошапкин В. Г. Липидный профиль и дислипопротеинемии у коренного сельского населения Якутии // Сибирский медицинский журнал (Томск). 2012. Т. 27, № 3. С. 142-146.
- Манчук В. Т., Надточий Л. А. Состояние и тенденции формирования здоровья коренного населения Севера и Сибири // Бюллетень СО РАМН. 2010. Т. 30, № 3. С. 24-32.
- Панин Л. Е. Гомеостаз и проблемы приполярной медицины (методологические аспекты адаптации) // Бюллетень СО РАМН. 2010. Т. 30, № 3. С. 6-11.
- Рябова Т. И., Попова Т. В. Липидный спектр сыворотки крови у коренного (эвены, нанайцы, ульчи) и пришлого населения Приамурья // Дальневосточный медицинский журнал. 2010. № 4. С. 106-108.
- Assman G, Gotto A. M. HDL cholesterol and protective factors in atherosclerosis // Circulation. 2004. Vol. 109. P. III-8-III-14.
- Boyer B., Mohatt G. V., Plaetke R. et al. Metabolic syndrome in Yup’ik Eskimos: the Center for Alaska Native Health Research (CANHR) Study // Obesity. 2007. Vol. 15, N 11. P 2535-2540.
- Chateau-Degat M. L., Dewailly E., Charbonneau G. et al. Obesity risks: towards an emerging Inuit pattern // Int. J. Circumpolar Health. 2011. Vol. 70, N 2. P. 166-177.
- de Knijff P., Johansen L. G., Rosseneu M. et al. Lipoprotein profile of a Greenland Inuit population. Influence of anthropometric variables, Apo E and A4 polymorphism, and lifestyle // Arterioscler Thromb. 1992. Vol. 12, N 12. P. 1371 - 1379.
- Dobiasova M., Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apo B-lipoprotein-depleted plasma. (FERHDL) // Clin Biochem. 2001. Vol. 34. P 583-588.
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) // JAMA. 2001. Vol. 285, N 19. P. 2486-2497.
- Gordon T., Castelli W. P., Hjortland M. C. et al. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study // Am. J. Med. 1977. Vol. 62, N 5. P. 707-714.
- Leonard W. R., Snodgrass J. J., Sorensen M. V. Metabolic adaptation in Indigenous Siberian populations // Annu Rev. Anthropol. 2005. Vol. 34. P. 451-471.