DYNAMICS OF EPIDEMIOLOGICAL PARAMETERS OF TYPE 1 DIABETES MELLITUS IN CHILDREN IN THE REPUBLIC OF KARELIA
- Authors: Varlamova TV1, Dorchakova NV1, Karapetyan TA1
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Affiliations:
- Petrozavodsk State University
- Issue: Vol 24, No 10 (2017)
- Pages: 52-56
- Section: Articles
- URL: https://journals.rcsi.science/1728-0869/article/view/16766
- DOI: https://doi.org/10.33396/1728-0869-2017-10-52-56
- ID: 16766
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Abstract
Type 1 diabetes mellitus is one of the most common autoimmune diseases in the world. The Republic of Karelia belongs to a group of regions with a high prevalence rate of type 1 diabetes mellitus (over 200 per 100,000 residents). In the last 20 years, type 1 diabetes incidence has increased 3.4 times, mostly due to the onset at an early age. The incidence rate of new cases of type 1 diabetes among children and adolescents does not show any clear linear dependence. Significant incidence occur every 4 or 5 years, which is most likely to be connected with an increase in the incidence of virus infection in these years. The primary incidence of type 1 diabetes mellitus among children per every 100 thousand of the child population is also higher in the Republic of Karelia compared to the Russian Federation. 17,4% children in Karelia have a genetic predisposition to type 1 diabetes mellitus (positive for HLA-DQB*0302 and/ or *02 and negative for the protective alleles *0602/03, *0301), which is lower than in Finland (23%).Genetic heterogeneity among ethnic populations in conjunction with environmental factors can determine the peculiarities of type 1 diabetes mellitus prevalence rate.
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##article.viewOnOriginalSite##About the authors
T V Varlamova
Petrozavodsk State University
Email: varlamova_ptz@mail.ru
кандидат медицинских наук, доцент кафедры педиатрии и детской хирургии 185910, г. Петрозаводск, пр. Ленина, д. 33
N V Dorchakova
Petrozavodsk State University
T A Karapetyan
Petrozavodsk State University
References
- Дедов И.И., Кураева Т.Л., Петеркова В.А. Сахарный диабет у детей и подростков. М.: Гэотар-Медиа, 2008. 160 с.
- Дедов И.И., Шестакова М.В., Викулова О.К. Государственный регистр сахарного диабета в Российской Федерации: статус 2014 г. и перспективы развития // Сахарный диабет. 2015. Т. 18, № 3. С. 5-23.
- Ширяева Т.Ю., Андрианова Е.А., Сунцов Ю.И. Динамика основных эпидемиологических показателей сахарного диабета 1 типа у детей в Российской Федерации // Сахарный диабет. 2010. № 4. С. 6-11.
- Ширяева Т.Ю., Андрианова Е.А., Сунцов Ю.И. Динамика основных эпидемиологических показателей сахарного диабета 1 типа у детей и подростков в Российской Федерации (2001-201 1 гг.) // Сахарный диабет. 2013. Т. 16, № 3. С. 21-29.
- Horchers A.T., Uibo R., Gershwin M.E. The geoepidemiology of type 1 diabetes // Autoimmun. Rev. 2010. Vol. 9, N 5. P 355-365.
- Dabelea D. The accelerating epidemic of childhood diabetes // Lancet. 2009. Vol. 373, N 9680. P 1999-2000.
- Haynes A., Hulsara M.K., Hower C., Jones T.W., Davis E.A. Regular peaks and troughs in the Australian incidence of childhood type 1 diabetes mellitus (2000-201 1) // Diabetologia. 2015. Vol. 58, N 11. P. 2513-2516.
- IDF Diabetes Atlas 7th edition. 2015. URL: http://www. diabetesatlas.org/ (дата обращения: 06.2016.)
- Knip M., Simell О. Environmental Triggers of Type 1 Diabetes // Cold Spring Harb. Perspect. Med. 2012. Vol. 2, N 7. P. 38-42.
- Knip M. Pathogenesis of type 1 diabetes: Implications for incidence trends // Horm. Res. 2011. Vol. 76. P 57-64.
- Liese A.D., Lawson A., Song H.R., Hibbert J.D., Porter D.E., Nichols M., Lamichhane A.P., Dabelea D., Mayer-Davis E.J., Standiford D., Liu L., Hamman R.F., DAgostino R.H. Jr. Evaluating geographic variation in type 1 and type 2 diabetes mellitus incidence in youth in four US regions // Jr. Health Place. 2010. Vol. 16, N 3. P. 547-556
- Patterson C.C., Dahlquist G.G., Gyürüs E., Green A., Soltsz G., EURODIAH Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study // Lancet. 2009. Vol. 13, N 373. P. 2027-2033.
- Serban V., Hrink S., Timar H., Sima A., Vlad M., Timar R., Vlad A. An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years // J. Pediatr. Endocrinol. Metab. 2015. Vol. 28, N 3. P. 293-298.
- Stanescu D.E., Lord K., Lipman T.H. The epidemiology of type 1 diabetes in children // Endocrinology and Metabolism Clinics of North America. 2012. Vol. 41, N 4. P. 679-694.
- Svensson J., Lyngaae-Jrgensen A., Carstensen H., Simonsen L.H., Mortensen H.H., Danish Childhood Diabetes R. Long-term trends in the incidence of type 1 diabetes in Denmark: the seasonal variation changes over time // Pediatric Diabetes. 2009. Vol. 10, № 4. P. 248-254.
- Teeäär T., Liivak N., Heilman K., Kool P., Sor R., Paal M., Einberg U., Tillmann V. Increasing incidence of childhood-onset type 1 diabetes mellitus among Estonian children in 1999-2006. Time trend analysis 1983-2006 // Pediatric Diabetes. 2010. Vol. 11. № 2. P 107-110.