THE POPULATIONS OF PERIPHERAL BLOOD LEUKOCYTES CARRYING ADHESION MOLECULES, IN PATIENTS WITH PSORIASIS


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Abstract

Migration of leukocytes through the endothelium of microcirculature is regulated by adhesion molecules. Taking into account the important role of leukocytes migration processes into the skin of patients with psoriasis information about the concentration of adhesion molecules on neutrophils, monocytes and lymphocytes considering their morphological features has not only theoretical but also practical interest, because regulation of this process gives new possibilities for therapy. The study of leukocytes migration mechanisms is necessary for predicting the course of the disease and justifying the search for new effective methods of treatment. The purpose of this research was to investigate the migration of leukocytes carrying adhesion molecules from the peripheral blood to the skin in psoriasis and their role in the development of the pathological process. The clinical and immunological examination of 82 patients with vulgar and exudative psoriasis in the progressive and inpatient stage (39 women and 43 men) aged 20 to 60 years was carried out. Duration of the disease was from 3 months to 10 years. As a control group, 50 practically healthy people were examined (28 women and 22 men). Microscopic venous blood smear was carried out, the segmentogram of neutrophils, lymphocytograms, monocytes were analyzed and at the same time the content of leukocytes expressing receptors for adhesion molecules was determined. Under conditions of hyperproliferation of keratinocytes, as observed in psoriasis, a decrease in the number of neutrophils carrying L-selectin molecules, ICAM-1, LFA-1, LFA-3, PECAM-1 was registered. The level of lymphocytes with the molecules of ICAM-1, LFA-3 slightly increased, but a number of lymphocytes with molecules of L-selectin, LFA-1, PECAM-1 decreased. Changes in the level of monocytes carrying adhesion molecules were absent. The results of the statistical analysis allowed assessing the relationship of peripheral blood leukocytes carrying adhesion molecules, with their morphological characteristics in patients with psoriasis.

About the authors

A K Sherstennikova

Northern State Medical University

Email: a.sherstennikova@yandex.ru
кандидат медицинских наук, доцент кафедры нормальной физиологии Arkhangelsk

S L Kashutin

North-Western State Medical University named by I. I. Mechnikov

Saint-Petersburg, Russia

V I Nikolaev

Northern State Medical University

Arkhangelsk

V S Neklyudova

Northern State Medical University

Arkhangelsk

L L Shagrov

North-Western State Medical University named by I. I. Mechnikov

Saint-Petersburg, Russia

S V Klyuchareva

North-Western State Medical University named by I. I. Mechnikov

Saint-Petersburg, Russia

V A Pyryatynsky

Northern State Medical University

Arkhangelsk

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