Email this article Carbonil stress parameters and DNA oxidative modification in Russian and Buryat women with age-related menopause
- Authors: Semenova N.V.1, Brichagina A.S.1, Nikitina O.A.1, Madaeva I.M.1, Kolesnikov S.I.1, Kolesnikova L.I.1
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Affiliations:
- Scientific Centre for Family Health and Human Reproduction Problems
- Issue: Vol 29, No 6 (2022)
- Pages: 415-423
- Section: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/1728-0869/article/view/105578
- DOI: https://doi.org/10.17816/humeco105578
- ID: 105578
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Abstract
BACKGROUND: Menopause is a risk factor for oxidative stress. Previous study results indicate the lipid peroxidation ethnospecificity, suggesting differences in the metabolism of different ethnic groups of women, associated with the oxidation of not only lipids but proteins and DNA.
AIM: To determine advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and DNA oxidative modification levels in the blood of Russian and Buryat peri- and postmenopausal women.
MATERIAL AND METHODS: The study involved 86 women of two ethnic groups — Russians (n=52) and Buryats (n=34) — aged 45 to 60 years with peri- and postmenopausal status, which participated as volunteers. The basis for the exclusion in this study was the use of hormone replacement therapy, antioxidant drugs, diseases of endocrine origin, exacerbation of chronic diseases, premature early menopause, and surgical menopause. The concentration of 8-hydroxy-2'-deoxyguanosine (ng/ml) and AGEs (ng/ml) was determined in blood serum by enzyme immunoassay. The content of AOPP (nmol/l) was determined in blood plasma using the photometric method.
RESULTS: An increase of AOPP levels in postmenopause as compared to perimenopause was found in women of both ethnic groups (36.90 [27.09; 42.72] and 19.80 [17.03; 23.78] in the Russian ethnic group (p <0.001) and 31.16 [29.45; 33.99] and 26.30 [23.44; 30.91] in the Buryat ethnic group (p=0.020). Regardless of the menopausal phase, the AGEs levels in Buryat women were higher than the Russian ethnic group: (5015.0 [4584.49; 5486.96] and 3685.87 [3376.11; 4318.0] in perimenopause (p=0.002) and 4970 [4710; 5660] and 4274.59 [3440.67; 4813.05] in postmenopause (p=0.040)) and 8-hydroxy-2'-deoxyguanosine (1.58 [0.66; 4.36] and 0.82 [0.42; 1.09] in perimenopause (p=0.032) and 1.52 [1.06; 4.21] and 0.85 [0.49; 1.34] in postmenopause (p=0.018)). Differences in the AOPP level were revealed only in the perimenopause toward a higher level in Buryat women.
CONCLUSION: Protein oxidation depends on the menopausal phase and is more pronounced in postmenopausal women. The carbonyl stress parameters and DNA destruction levels are higher in Buryat women than Russian ethnic group.
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##article.viewOnOriginalSite##About the authors
Natalya V. Semenova
Scientific Centre for Family Health and Human Reproduction Problems
Author for correspondence.
Email: natkor_84@mail.ru
ORCID iD: 0000-0002-6512-1335
SPIN-code: 6606-0160
Dr. Sci. (Biol.), leader research associate
Russian Federation, IrkutskAnastasia S. Brichagina
Scientific Centre for Family Health and Human Reproduction Problems
Email: tasi121212@mail.ru
ORCID iD: 0000-0003-1055-4608
SPIN-code: 4374-3460
PhD student, junior research associate
Russian Federation, IrkutskOlga A. Nikitina
Scientific Centre for Family Health and Human Reproduction Problems
Email: olga_tolpygina@mail.ru
ORCID iD: 0000-0003-1926-9694
SPIN-code: 1799-4973
Cand. Sci. (Biol.), research associate
Russian Federation, IrkutskIrina M. Madaeva
Scientific Centre for Family Health and Human Reproduction Problems
Email: nightchild@mail.ru
ORCID iD: 0000-0003-3423-7260
SPIN-code: 9869-7793
Dr. Sci. (Med.), chief research associate
Russian Federation, IrkutskSergey I. Kolesnikov
Scientific Centre for Family Health and Human Reproduction Problems
Email: sikolesnikov2012@gmail.com
ORCID iD: 0000-0003-2124-6328
SPIN-code: 1752-6695
academician of the Russian academy of sciences, Dr. Sci. (Med.), chief research associate
Russian Federation, IrkutskLyubov I. Kolesnikova
Scientific Centre for Family Health and Human Reproduction Problems
Email: kolesnikova20121@mail.ru
ORCID iD: 0000-0003-3354-2992
SPIN-code: 1584-0281
academician of the Russian academy of sciences, Dr. Sci. (Med.)
Russian Federation, IrkutskReferences
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