The influence of glyprolins on the behavior of laboratory animals under experimental hyperthyroidism
- 作者: Sergalieva M.1, Tsibizova A.1, Abdulkadyrova E.1, Andreeva L.2, Samotrueva M.1, Myasoedov N.2
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隶属关系:
- Astrakhan State Medical University
- Kurchatov Institute — Institute of Molecular Genetics
- 期: 卷 23, 编号 4 (2021)
- 页面: 179-186
- 栏目: Experimental trials
- URL: https://journals.rcsi.science/1682-7392/article/view/66467
- DOI: https://doi.org/10.17816/brmma66467
- ID: 66467
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详细
This study aimed to determine the peculiarities of behavioral reactions and psychoemotional status of laboratory animals in experimental hyperthyroidism conditions against the background of introducing peptides of glyproline series (selank and tripeptide Pro-Gly-Pro). All experiments were conducted on white non-linear male rats, which were divided into groups consisting of 10 individuals. The first group consisted of control rats that received intraperitoneal water for injection in equi-volume. The second group consisted of individuals with experimental hyperthyroidism modeled by intragastric administration of L-thyroxine “Berlin-Chemi” Germany) at 150 mcg/kg/day for 21 days. The third and fourth groups were animals with a hyperthyroidism model and received intraperitoneal Selank and Pro-Gly-Pro at 200 mcg/kg/day for 21 days after the hyperthyroidism model development. The behavioral activity determination of laboratory animals was conducted using the “Open Field” method, which is widely used in the analysis of approximate research activity, locomotive stereotyping, and the emotional reactivity level of rodents. The level of animal anxiety was assessed using the Raised cross-shaped maze method. The study revealed that experimental hyperthyroidism due to the introduction of L-thyroxine is accompanied by an increased level of the anxiety-depressive state in the behavior of male rats. The study on the effects of selank and its structural analog Pro-Gly-Pro on the psychoemotional status of male rats using Open Field and Raised cruciform labyrinth methods revealed that the recovery of the approximate research motor activity of laboratory animals is noted, which indicates the psychomodulatory activity of glyproline neuropeptides, in experimental hyperthyroidism conditions.
作者简介
Mariyam Sergalieva
Astrakhan State Medical University
编辑信件的主要联系方式.
Email: charlina_astr@mail.ru
ORCID iD: 0000-0002-9630-2913
SPIN 代码: 7976-9321
candidate of biological sciences
俄罗斯联邦, AstrakhanAlexsandra Tsibizova
Astrakhan State Medical University
Email: sasha3633@yandex.ru
ORCID iD: 0000-0002-9994-4751
SPIN 代码: 2206-3898
candidate of pharmaceutical sciences
俄罗斯联邦, AstrakhanElvira Abdulkadyrova
Astrakhan State Medical University
Email: elvira_abdulkadyrova@mail.ru
graduate student
俄罗斯联邦, AstrakhanLudmila Andreeva
Kurchatov Institute — Institute of Molecular Genetics
Email: landr@img.ras.ru
ORCID iD: 0000-0002-3927-8590
SPIN 代码: 4785-5621
sector manager
俄罗斯联邦, MoscowMarina Samotrueva
Astrakhan State Medical University
Email: ms1506@mail.ru
ORCID iD: 0000-0001-5336-4455
SPIN 代码: 5918-1341
doctor of medical sciences, professor
俄罗斯联邦, AstrakhanNikolay Myasoedov
Kurchatov Institute — Institute of Molecular Genetics
Email: nfm@img.ras.ru
ORCID iD: 0000-0003-1294-102X
SPIN 代码: 1262-2698
doctor of chemical sciences, professor
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