Polymorphisms of leukocyte genes human and congenital antigen immunity associated with different the severity of the course of the new coronavirus infections
- 作者: Butusov A.1, Krusko O.1, Potapov P.2, Derevyankin D.1, Zagranichnov V.1, Malyshkin S.1, Zhurbin E.1
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隶属关系:
- Military Innovation Technopolis “ERA”
- Military Innovative Technopolis "ERA"
- 期: 卷 24, 编号 3 (2022)
- 页面: 547-556
- 栏目: Review
- URL: https://journals.rcsi.science/1682-7392/article/view/108133
- DOI: https://doi.org/10.17816/brmma108133
- ID: 108133
如何引用文章
详细
The most significant single nucleotide human leukocyte antigen genes polymorphisms and innate immunity genes associated with varying degrees of acute respiratory infection severity are considered–COVID-19 caused by the SARS-CoV-2 coronavirus. As data accumulated, it became clear that the SARS-CoV-2 virus exhibits significant regional, ethnic, and individual specificity. This is due to the population groups’ genetic characteristics. This is necessary to reliably know the human genotype relationship with the COVID-19 course severity (asymptomatic, mild, moderate, severe, and extremely severe up to fatal outcomes) for more successful therapy and vaccination. At the same time, it was also known that the innate immunity system is on the first line of defense against the pathogenic penetration into the body, and the human leukocyte antigen system encodes molecules of the same name on the surface of cells that present various antigens, including viral infection pathogens, and determine the severity of the course of many diseases; therefore, these systems’ genes. This approach makes it possible to assess the likelihood of a severe and extremely severe disease course in healthy and infected people, which in turn contributes to the correct therapy strategy, pharmacotherapy, and vaccination, as well as to create new antiviral therapeutic and preventive medicines. The genetically determined immune response heterogeneity to SARS-CoV-2 infection requires further study, since there is no unambiguous opinion about the leading mechanism that determines disease severity.
作者简介
Alexander Butusov
Military Innovation Technopolis “ERA”
Email: butus98@yandex.ru
ORCID iD: 0000-0002-3074-2449
Master
俄罗斯联邦, AnapaOlga Krusko
Military Innovation Technopolis “ERA”
Email: panarinaolya08@mail.ru
ORCID iD: 0000-0001-9111-7914
SPIN 代码: 4702-6002
Candidate of Biological Sciences
俄罗斯联邦, AnapaPetr Potapov
Military Innovative Technopolis "ERA"
Email: forwardspb@mail.ru
SPIN 代码: 5979-4490
Candidate of Medical Sciences
俄罗斯联邦, AnapaDmitriy Derevyankin
Military Innovation Technopolis “ERA”
Email: derev.dima1@yandex.ru
ORCID iD: 0000-0003-0370-0347
Master
俄罗斯联邦, AnapaValentin Zagranichnov
Military Innovation Technopolis “ERA”
Email: valentin.zagranichnov@yandex.ru
ORCID iD: 0000-0003-0238-8486
Resident
俄罗斯联邦, AnapaSvyatoslav Malyshkin
Military Innovation Technopolis “ERA”
编辑信件的主要联系方式.
Email: svytoslavmal@gmail.com
ORCID iD: 0000-0003-4366-0028
SPIN 代码: 8109-3446
Master
俄罗斯联邦, AnapaEvgeniy Zhurbin
Military Innovation Technopolis “ERA”
Email: zhurbin-90@mail.ru
ORCID iD: 0000-0002-0867-3838
SPIN 代码: 8426-1354
Scopus 作者 ID: 57198886746
Candidate of Medical Sciences
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