The development and experimental assessment of medical devices protecting eviscerated abdominal organs using the eventration model
- Authors: Adamenko V.N.1, Golovko K.P.1,2, Suborova T.N.1, Toropova Y.G.3, Zaichikov D.A.4
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Affiliations:
- Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
- Saint Petersburg State University
- Almazov National Medical Research Center
- State Institute for Experimental Military Medicine of the Ministry of Defense of the Russian Federation
- Issue: Vol 23, No 3 (2021)
- Pages: 165-176
- Section: Experimental trials
- URL: https://journals.rcsi.science/1682-7392/article/view/70960
- DOI: https://doi.org/10.17816/brmma70960
- ID: 70960
Cite item
Abstract
On an experimental model of eventration in small and large animals (94 rats and 12 pigs), the safety and effectiveness of samples of aseptic protective dressings made of nanomaterials with impregnations used to prevent the development of complications from abdominal organs and tissues in comparison with control ones — gauze medical sterile ones were evaluated. After 3 hours, 3 and 7 days after surgery, the viability of the intestinal wall and the presence of complications were assessed on the basis of laboratory, experimental, instrumental and morphological techniques. The assessment of microcirculation (perfusion) of the intestine was carried out using the apparatus “LAKK-02”. It was found that according to the complex of clinical and laboratory, microbiological, morphological, microcirculatory data and expert assessment, the safest and most effective for the protection of abdominal organs was an aseptic bandage made of non-woven material spunbond impregnated with vinylin + silicone. The initial values of microcirculation parameters in the pig groups were: 18.4 [17.1; 19] perfusion units in the experimental group and 15.6 [6.8; 17.7] perfusion units in the control group. After applying the bandage in the experimental group, the level of microcirculation did not significantly change. In the control group, after 3-hour exposure to the bandage, a decrease in the level of microcirculation was observed to 6.5 [5.1; 8] perfusion units (p < 0.05 compared to the initial and similar stage in the experimental group). Thus, an aseptic bandage made of spunbond nanomaterial impregnated with vinylin + silicone retains the necessary moisture and protects the eventrated abdominal organs, demonstrates safe adhesive properties and prevents the development of local and general complications in the early postoperative period.
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##article.viewOnOriginalSite##About the authors
Valeriy N. Adamenko
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Author for correspondence.
Email: adavalnik@mail.ru
ORCID iD: 0000-0003-0420-8047
SPIN-code: 6212-2960
senior staff scientist
Russian Federation, Saint PetersburgKonstantin P. Golovko
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation; Saint Petersburg State University
Email: labws@mail.ru
ORCID iD: 0000-0002-1584-1748
SPIN-code: 2299-6153
doctor of medical sciences, associate professor
Russian Federation, Saint Petersburg; Saint PetersburgTatiana N. Suborova
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: microbiologma@list.ru
ORCID iD: 0000-0002-6783-1920
SPIN-code: 9771-5906
doctor of biological science
Russian Federation, Saint PetersburgYana G. Toropova
Almazov National Medical Research Center
Email: yana.toropova@mail.ru
ORCID iD: 0000-0003-1629-7868
SPIN-code: 2020-4213
candidate of biology sciences
Russian Federation, Saint PetersburgDenis A. Zaichikov
State Institute for Experimental Military Medicine of the Ministry of Defense of the Russian Federation
Email: dazai@list.ru
SPIN-code: 1037-3860
candidate of medical science
Russian Federation, Saint PetersburgReferences
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