Immunoprotective therapy for suppression of humoral immune response induced by hypoxia and toxemia

V. N. Alexandrov; Александров В. Н.; I. V. Zarubin; Зарубина И. В.; A. A. Kondratenko; Кондратенко А. А.; E. V. Mikhaylova; Михайлова Е. В.; S. V. Kromskiy; Кромский С. В.; L. P. Sigareva; Сигарева Л. П.; V. A. Gorichny; Горичный В. А.; N. V. Pak; Пак Н. В.; P. A. Slizhov; Слижов П. А.; A. A. Kokorina; Кокорина А. А.

doi:10.17816/brmma62815

Immunoprotective therapy for suppression of humoral immune response induced by hypoxia and toxemia

Authors: Alexandrov V.N.¹^,2, Zarubin I.V.¹, Kondratenko A.A.¹, Mikhaylova E.V.², Kromskiy S.V.², Sigareva L.P.², Gorichny V.A.¹, Pak N.V.¹, Slizhov P.A.¹, Kokorina A.A.¹
Affiliations:
1. Military medical academy of S.M. Kirov
2. Saint-Petersburg State Pediatric Medical University
Issue: Vol 22, No 4 (2020)
Pages: 107-110
Section: Experimental trials
URL: https://journals.rcsi.science/1682-7392/article/view/62815
DOI: https://doi.org/10.17816/brmma62815
ID: 62815

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Abstract

The possibility of using preparations limiting toxemia and hypoxia, in particular inhibitors of proteoletic enzymes and antihypoxants, as preparations having immunoprotective activity is considered. Under the conditions of the experimental model of severe mechanical injury on mice-hybrids of the first generation F1 (CBA×C57BL6), the immunoprotective activity of such antihypoxants as amtisol and a derivative of 1, 2, 4-triazino-5, 6 indole, as well as a counterkal, a drug limiting toxemia and a cationoacceptor preparation of dimexide, administered to immunized erythythermal It has been shown that in the body of mice receiving antihypoxants, contrical and dimexide accumulate significantly more antibody-forming cells compared to their number in animals of the control group. Thus, amtisol, a derivative of 1, 2, 4-triazino-5, 6 indole, contrical and dimexide can be considered not only as preparations for pathogenetic therapy of trauma, but also as immunoprotectors – drugs that indirectly limit the formation of post-traumatic immunodeficiency and the risk of infection in an immunocompromised host. The risk of infectious complications and the generalization of the inflammatory process in patients after severe mechanical injury is more than 50%. Prevention of infectious complications of traumatic disease should be comprehensive and aimed at correcting the function of the immune system.