A comparative evaluation of the effectiveness of aspiration and automatic systems for percutaneous liver biopsy in experimental rats

K V Zhdanov; Жданов К В; A V Saulevich; Саулевич А В; V E Karev; Карев В Е; K V Kozlov; Козлов К В; Yu F Zakharkiv; Захаркив Ю Ф; S M Zakharenko; Захаренко С М; Yu I Lyashenko; Ляшенко Ю И; K S Ivanov; Иванов К С; V S Sukachev; Сукачев В С; D M Shakhmanov; Шахманов Д М; D V Popov; Попов Д В; S S Kariakin; Карякин С С; A V Bedarev; Бедарев А В; M G Chernenok; Черненок М Г; I I Gemst; Гемст И И; M M Tashimov; Ташимов М М

doi:10.17816/brmma25933

A comparative evaluation of the effectiveness of aspiration and automatic systems for percutaneous liver biopsy in experimental rats

Authors: Zhdanov KV¹, Saulevich AV¹, Karev VE², Kozlov KV¹, Zakharkiv Y.F¹, Zakharenko SM¹, Lyashenko Y.I¹, Ivanov KS¹, Sukachev VS¹, Shakhmanov DM¹, Popov DV¹, Kariakin SS¹, Bedarev AV¹, Chernenok MG¹, Gemst II¹, Tashimov MM³
Affiliations:
1. Военно-медицинская академия им. С.М. Кирова
2. Детский научно-клинический центр инфекционных болезней
3. 1477-й Военно-морской клинический госпиталь
Issue: Vol 21, No 2 (2019)
Pages: 133-139
Section: Articles
URL: https://journals.rcsi.science/1682-7392/article/view/25933
DOI: https://doi.org/10.17816/brmma25933
ID: 25933

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Abstract

The effectiveness and quality of liver biopsy in rats are applicable to the aspiration and automatic liver biopsy system. Histological examination of 240 biopsy specimens in 100% of cases identified portal tracts. The number of portal tracts to determine the stage of liver fibrosis in rats of the 1st group who underwent liver biopsy was performed using an 18 G aspirating needle from the puncture liver set (Menghini type), which is 4-5, you have the 2nd group, which one-time guillotine soft tissue biopsy with a semi-automatic action of 16G×20 cm, Italy) - 7-8 portal tracts. The average size of the biopsy in the 1st group is 0,5 cm, in the 2nd group - 1 cm. Thus, the automatic biopsy system allows you to get liver tissue in 100% of cases. At the same time, the automatic system eliminates the additional traumatization of experimental animals, as well as minimizes efforts to separate the biopsy material from the organ. In addition, the automated system for liver biopsy allows to evaluate 7-8 portal tracts with a biopsy size of 1 cm, this provides a reliable histological assessment of pathological changes in liver tissue to assess the stage of fibrosis and the activity of the inflammatory process over time.

Keywords

cirrhosis, liver biopsy, carbon tetrachloride, chronic liver disease, experimental model, toxic hepatitis, rats, chronic viral hepatitis, progression of fibrosis, fibrosis

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Vol 26, No 1 (2024)

A comparative evaluation of the effectiveness of aspiration and automatic systems for percutaneous liver biopsy in experimental rats

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Abstract

Keywords

Full Text

About the authors

K V Zhdanov

A V Saulevich

V E Karev

K V Kozlov

Yu F Zakharkiv

S M Zakharenko

Yu I Lyashenko

K S Ivanov

V S Sukachev

D M Shakhmanov

D V Popov

S S Kariakin

A V Bedarev

M G Chernenok

I I Gemst

M M Tashimov

References

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