Ultraphonophoresis of an enzyme gel with direct proteolytic activity in patients with hypertrophic skin scars

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BACKGROUND: Correction and prevention of severe cicatricial deformities is a labor-intensive task for doctors of aesthetic and rehabilitation medicine. Often, as a result of skin scarring, the psychological status of the patient changes due to the presence of persistent subjective sensations or the location of defects in open, functionally active areas of the skin. The steady annual growth in trauma, the number of surgical interventions and invasive procedures actualizes the question of finding an optimal, effective and widely available method for preventing severe skin scarring or correcting fibrous deformities.

AIM: scientific and practical substantiation of the use of enzyme gel ultraphonophoresis with direct proteolytic activity in patients with hypertrophic skin scars.

MATERIALS AND METHODS: A prospective interventional cohort comparative study of the efficacy and safety of enzyme gel ultraphonophoresis with direct proteolytic activity in patients with hypertrophic skin scars was performed. The study included 42 patients with a diagnosis of "Hypertrophic scars" (ICD-10, L91) of postoperative or post-traumatic genesis, divided into observation and comparison groups with emerging (n=20) and mature (n=22) scars. In the course of the study, clinical, instrumental and medical and sociological research methods were used.

RESULTS: A pronounced positive dynamic of indicators of clinical and instrumental parameters of scar tissue was established, improvement of quality-of-life indicators was the most significant in patients of the observation group with developing scars. The expediency of using the enzyme gel ultraphonophoresis technique with direct proteolytic activity in patients with hypertrophic skin scars is confirmed by a combination of parameters: positive dynamics of the clinical status, functional properties of scar tissue and quality of life indicators, a high safety profile and patient satisfaction with treatment. The effectiveness of correction in patients with developing and mature hypertrophic scars was 83–87%.

CONCLUSION: The therapeutic and preventive technology of enzyme gel ultraphonophoresis with direct proteolytic activity is an effective and promising method for the correction and prevention of postoperative and post-traumatic cicatricial skin defects.

作者简介

Inna Gritskova

Kirov Military Medical Academy

编辑信件的主要联系方式.
Email: inusik2002klan@mail.ru
ORCID iD: 0000-0002-0549-4009
SPIN 代码: 6004-6546
俄罗斯联邦, 6 Akademik Lebedev street, 194044 Saint Petersburg

Inga Ponomarenko

Kirov Military Medical Academy; North-Western State Medical University named after I.I. Mechnikov

Email: manga-85@mail.ru
ORCID iD: 0000-0001-6550-6940
SPIN 代码: 7930-2463

MD, Dr. Sci. (Med.), Associate Professor

俄罗斯联邦, 6 Akademik Lebedev street, 194044 Saint Petersburg; Saint Petersburg

Irina Cherkashina

Federal Scientific Center of Rehabilitation of the Disabled named after G.A. Albrecht

Email: vulan1507@mail.ru
ORCID iD: 0000-0002-5839-1433
SPIN 代码: 7991-9023
俄罗斯联邦, Saint Petersburg

参考

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2. Fig. 1. Clinical picture of a hypertrophic scar before physiotherapy.

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3. Fig. 2. Dynamics of clinical signs of a hypertrophic scar after the end of a course of ultraphonophoresis of enzyme gel with high proteolytic activity.

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