The dynamics of allodynia in the treatment of patients with diabetic polyneuropathy using transcutaneous electroneurostimulation
- 作者: Al-Zamil M.1,2, Kulikova N.1, Vasilieva E.3, Elfimov M.4
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隶属关系:
- Peoples' Friendship University of Russia
- "Olivia" Brain and Spine Clinic
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimova
- Central State Medical Academy of Department of Presidential Affairs
- 期: 卷 20, 编号 3 (2021)
- 页面: 187-192
- 栏目: Original studies
- URL: https://journals.rcsi.science/1681-3456/article/view/106149
- DOI: https://doi.org/10.17816/1681-3456-2021-20-187-192
- ID: 106149
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详细
BACKGROUND: Allodynia, hyperalgesia, and positive sensory symptoms are the main symptoms of neuropathic pain. Studying these symptoms and their dynamics in the treatment of neuropathic pain broadens our understanding of neuropathic pain and how it can be treated.
AIMS: To study the effect of different TENS modalities on allodynia in patients with severe neuropathic pain syndrome developed against the background of diabetic distal polyneuropathy of the lower extremities.
MATERIAL AND METHODS: 75 patients with allodynia on the background of distal polyneuropathy of the lower extremities (DPLE) were treated with pharmacotherapy (n=26), high-frequency TENS (n=25), and low-frequency TENS (n=24).
RESULTS: Immediately after treatment, we observed a more pronounced decrease in allodynia after the application of high-frequency TENS (by 72.2%) and low-frequency TENS (by 61.1%). Moreover, in the control group, the regression of allodynia averaged 28.6%. At the 2nd month of the long-term period, the severity of allodynia continued to decrease more rapidly against the background of high-frequency TENS (26.7%) than after low-frequency TENS (19%) and remained without significant dynamics against the background of pharmacotherapy.
CONCLUSION: The use of TENS 1.3 times enhances the therapeutic effect of pharmacotherapy in treatment of neuropathic pain in patients with diabetic DPLE. High-frequency TENS is more effective than low-frequency TENS in the treatment of allodynia by 18.2% immediately after treatment and by 40% at the end of the 2nd long-term period. By the 6th month of the long-term period, the results of treatment in both groups did not differ significantly.
作者简介
Mustafa Al-Zamil
Peoples' Friendship University of Russia; "Olivia" Brain and Spine Clinic
编辑信件的主要联系方式.
Email: alzamil@mail.ru
ORCID iD: 0000-0002-3643-982X
SPIN 代码: 3434-9150
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Moscow; PodolskNatalia Kulikova
Peoples' Friendship University of Russia
Email: alzamil@mail.ru
SPIN 代码: 1827-7880
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, MoscowEkaterina Vasilieva
Moscow State University of Medicine and Dentistry named after A.I. Evdokimova
Email: alzamil@mail.ru
ORCID iD: 0000-0003-3087-3067
SPIN 代码: 5423-8408
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, MoscowMikhail Elfimov
Central State Medical Academy of Department of Presidential Affairs
Email: alzamil@mail.ru
ORCID iD: 0000-0001-6153-9673
MD, Dr. Sci. (Med.)
俄罗斯联邦, Moscow参考
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