Роль макроэлементов в развитии и прогрессировании новой коронавирусной инфекции (обзор литературы)
- Авторы: Романов А.О.1, Шарипова М.М.1, Ивкина М.В.1, Архангельская А.Н.1, Гуревич К.Г.1
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Учреждения:
- Московский государственный медико-стоматологический университет имени А.И. Евдокимова
- Выпуск: Том 20, № 5 (2021)
- Страницы: 449-459
- Раздел: Обзоры
- URL: https://journals.rcsi.science/1681-3456/article/view/106860
- DOI: https://doi.org/10.17816/rjpbr106860
- ID: 106860
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Аннотация
В статье представлен краткий обзор данных о влиянии изменения содержания основных макроэлементов (натрия, кальция, калия и магния) на заболеваемость и течение COVID-19. Проанализированы особенности нарушений баланса минеральных веществ у пациентов с новой коронавирусной инфекцией, продемонстрирована роль электролитных нарушений в увеличении частоты осложнений и повышении смертности среди пациентов с COVID-19. Описаны возможные механизмы дисбаланса макроэлементов, возникающие при заражении SARS-CoV-2.
Поиск публикаций по изменениям содержания магния, калия, кальция и натрия у пациентов с COVID-19, а также их влиянию на развитие и прогрессирование заболевания проводился с использованием баз данных Web of Science, Scopus, MedLine, The Cochrane Library, Embase, Global Health, CyberLeninka, РИНЦ. Кроме того, были проанализированы публикации из журналов, рецензируемых ВАК, а также международных и регионарных журналов.
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Алексей Олегович Романов
Московский государственный медико-стоматологический университет имени А.И. Евдокимова
Email: terekhova_m@mail.ru
ORCID iD: 0000-0002-5085-4587
SPIN-код: 2974-7992
Россия, Москва
Майсият Магомедовна Шарипова
Московский государственный медико-стоматологический университет имени А.И. Евдокимова
Email: terekhova_m@mail.ru
ORCID iD: 0000-0001-7452-1122
SPIN-код: 8438-6386
к.м.н.
Россия, МоскваМария Валентиновна Ивкина
Московский государственный медико-стоматологический университет имени А.И. Евдокимова
Автор, ответственный за переписку.
Email: terekhova_m@mail.ru
ORCID iD: 0000-0001-5261-3552
SPIN-код: 7054-2171
к.м.н.
Россия, МоскваАнна Николаевна Архангельская
Московский государственный медико-стоматологический университет имени А.И. Евдокимова
Email: terekhova_m@mail.ru
ORCID iD: 0000-0002-0792-6194
SPIN-код: 4434-5712
к.м.н., доцент
Россия, МоскваКонстантин Георгиевич Гуревич
Московский государственный медико-стоматологический университет имени А.И. Евдокимова
Email: terekhova_m@mail.ru
ORCID iD: 0000-0002-7603-6064
SPIN-код: 4344-3045
д.м.н.
Россия, МоскваСписок литературы
- Рылова Н.В., Троегубова Н.А., Жолинский А.В., и др. Оценка минерального статуса у юных спортсменов // Российский вестник перинатологии и педиатрии. 2017. Т. 62, № 5. C. 175–183. doi: 10.21508/1027-4065-2017-62-5-175-183
- Galmés S., Serra F., Palou A. Current state of evidence: influence of nutritional and nutrigenetic factors on immunity in the COVID-19 pandemic framework // Nutrients. 2020. Vol. 12, N 9. P. 2738. doi: 10.3390/nu12092738
- Wessels I., Rolles B., Slusarenko A., Rink L. Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19 // Br J Nutrition. 2022. Vol. 127, N 2. P. 214–232. doi: 10.1017/S0007114521000738
- Vogel-González M., Talló-Parra M., Herrera-Fernández V., et al. Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 Infection // Nutrients. 2021. Vol. 13, N 2. P. 562. doi: 10.3390/nu13020562
- Im J.H., Je Y.S., Baek J., et al. Nutritional status of patients with COVID-19 // Int J Infect Dis. 2020. N 100. P. 390–393. doi: 10.1016/j.ijid.2020.08.018
- Heller R.A., Sun Q., Hackler J., et al. Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker // Redox Biol. 2021. N 38. P. 101764. doi: 10.1016/j.redox.2020.101764
- Zhao K., Huang J., Dai D., et al. Serum iron level as a potential predictor of coronavirus disease 2019 severity and mortality: a retrospective study // Open Forum Infect Dis. 2020. Vol. 7, N 7. P. ofaa250. doi: 10.1093/ofid/ofaa250
- Pincemail J., Cavalier E., Charlier C., et al. Oxidative stress status in COVID-19 Patients hospitalized in intensive care unit for severe pneumonia // A Pilot Study. Antioxidants (Basel). 2021. Vol. 10, N 2. P. 257. doi: 10.3390/antiox10020257
- Lippi G., South A.M., Henry B.M. Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19) // Ann Clin Biochem. 2020. Vol. 57, N 3. P. 262–265. doi: 10.1177/0004563220922255
- Samad N., Sodunke T.E., Abubakar A.R., et al. The implications of zinc therapy in combating the COVID-19 global pandemic // J Inflamm Res. 2021. N 14. Р. 527–550. doi: 10.2147/JIR.S295377
- Perera M., El Khoury J., Chinni V., et al. Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol // BMJ Open. 2020. Vol. 10, N 12. P. e040580. doi: 10.1136/bmjopen-2020-040580
- Doboszewska U., Wlaź P., Nowak G., Młyniec K. Targeting zinc metalloenzymes in coronavirus disease 2019 // Br J Pharmacol. 2020. Vol. 177, N 21. P. 4887–4898. doi: 10.1111/bph.15199
- Notz Q., Herrmann J., Schlesinger T., et al. Clinical significance of micronutrient supplementation in critically Ill COVID-19 patients with severe ARDS // Nutrients. 2021. Vol. 13, N 6. P. 2113. doi: 10.3390/nu13062113
- Tan C.W., Ho L.P., Kalimuddin S., et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19) // Nutrition. 2020. N 79-80. P. 111017. doi: 10.1016/j.nut.2020.111017
- Leung C. Clinical features of deaths in the novel coronavirus epidemic in China // Rev Med Virol. 2020. Vol. 30, N 3. P. e2103. doi: 10.1002/rmv.2103
- Wu D., Wu T., Liu Q., Yang Z. The SARS-CoV-2 outbreak: what we know // Int J Infect Dis. 2020. N 94. P. 44–48. doi: 10.1016/j.ijid.2020.03.004
- Weston S., Frieman M.B. COVID-19: Knowns, unknowns, and questions // mSphere. 2020. Vol. 5, N 2. P. e00203–00220. doi: 10.1128/mSphere.00203-20
- Rahman M.T., Idid S.Z. Can Zn be a critical element in COVID-19 treatment? // Biol Trace Elem Res. 2021. Vol. 199, N 2. P. 550–558. doi: 10.1007/s12011-020-02194-9
- Lake M.A. What we know so far: COVID-19 current clinical knowledge and research // Clin Med (Lond.) 2020. Vol. 20, N 2. P. 124–127. doi: 10.7861/clinmed.2019-coron
- Rothan H.A., Byrareddy S.N. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak // J Autoimmun. 2020. N 109. P. 102433. doi: 10.1016/j.jaut.2020.102433
- Nedjimi B. Can trace element supplementations (Cu, Se, and Zn) enhance human immunity against COVID-19 and its new variants? // Beni Suef Univ J Basic Appl Sci. 2021. Vol. 10, N 1. P. 33. doi: 10.1186/s43088-021-00123-w
- Громова О.А. Торшин И.Ю. Важность цинка для поддержания активности белков врожденного противовирусного иммунитета: анализ публикаций, посвященных COVID-19 // Профилактическая медицина. 2020. Т. 23, № 3. C. 131–139. doi: 10.17116/profmed202023031131
- Chaturvedi U.C., Shrivastava R., Upreti R.K. Viral infections and trace elements: a complex interaction // Cur Sci. 2004. Vol. 87, N 10. P. 1536–1554.
- Calder P.C. Nutrition, immunity and COVID-19 // BMJ Nutr Prev Health. 2020. Vol. 3, N 1. P. 74–92. doi: 10.1136/bmjnph-2020-000085
- Dharmalingam K., Birdi A., Tomo S., et al. Trace elements as immunoregulators in SARS-CoV-2 and other viral infections // Indian J Clin Biochem. 2021. Vol. 36, N 4. P. 416–426. doi: 10.1007/s12291-021-00961-6
- Skalny A.V., Rink L., Ajsuvakova O.P., et al. Zinc and respiratory tract infections: Perspectives for COVID19 (Review) // Int J Mol Med. 2020. Vol. 46, N 1. P. 17–26. doi: 10.3892/ijmm.2020.4575
- Tang C.F., Ding H., Jiao R.Q., et al. Possibility of magnesium supplementation for supportive treatment in patients with COVID-19 // Eur J Pharmacol. 2020. N 886. P. 173546. doi: 10.1016/j.ejphar.2020.173546
- Jeong I.K., Yoon K.H., Lee M.K. Diabetes and COVID-19: global and regional perspectives // Diabetes Res Clin Pract. 2020. N 166. P. 108303. doi: 10.1016/j.diabres.2020.108303
- Fernández-Cao J.C., Warthon-Medina M., Moran V., et al. Zinc intake and status and risk of type 2 diabetes mellitus: a systematic review and meta-analysis // Nutrients. 2019. Vol. 11, N 5. P. 1027. doi: 10.3390/nu11051027
- Dubey P., Thakur V., Chattopadhyay M. Role of minerals and trace elements in diabetes and insulin resistance // Nutrients. 2020. Vol. 12, N 6. P. 1864. doi: 10.3390/nu12061864
- Громова О.А., Торшин И.Ю., Калачева А.Г. Дотации магния для повышения резерва адаптации и стрессоустойчивости организма в период пандемии // РМЖ. 2020. Режим доступа: https://www.rmj.ru/articles/infektsionnye_bolezni/dotatsii-magniya-dlya-povysheniya-rezerva-adaptatsii-i-stressoustoychivosti-organizma-v-period-pandemii/#ixzz79qOfPGI1. Дата обращения: 15.02.2021.
- Mathew A.A., Panonnummal R. ‘Magnesium’-the master cation-as a drug-possibilities and evidences // Biometals. 2021. Vol. 34, N 5. P. 955–986. doi: 10.1007/s10534-021-00328-7
- Tezcan M.E., Dogan Gokce G., Sen N., et al. Baseline electrolyte abnormalities would be related to poor prognosis in hospitalized coronavirus disease 2019 patients // New Microbes New Infect. 2020. N 37. P. 100753. doi: 10.1016/j.nmni.2020.100753
- Kumar P., Kumar M., Bedi O., et al. Role of vitamins and minerals as immunity boosters in COVID-19 // Inflammopharmacology. 2021. Vol. 29, N 4. P. 1001–1016. doi: 10.1007/s10787-021-00826-7
- Houillier P. Sodium homeostasis. (In French) // Nephrol Ther. 2007. Vol. 3, Suppl 2. P. S91–93. doi: 10.1016/s1769-7255(07)80014-9
- Voets P.J., Vogtländer N.P., Kaasjager K.A. Understanding dysnatremia // J Clin Monit Comput. 2021. Vol. 35, N 3. P. 655–659. doi: 10.1007/s10877-020-00512-z
- Ruiz-Sánchez J.G., Núñez-Gil I.J., Cuesta M., et al. Prognostic impact of hyponatremia and hypernatremia in COVID-19 pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry analysis // Front Endocrinol (Lausanne). 2020. N 11. P. 599255. doi: 10.3389/fendo.2020.599255
- Hu W., Lv X., Li C., et al. Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study // Intern Emerg Med. 2021. Vol. 16, N 4. P. 853–862. doi: 10.1007/s11739-020-02515-9
- Aggarwal S., Garcia-Telles N., Aggarwal G., et al. Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): early report from the United States // Diagnosis (Berl). 2020. Vol. 7, N 2. P. 91–96. doi: 10.1515/dx-2020-0046
- De Carvalho H., Letellier T., Karakachoff M., et al. Hyponatremia is associated with poor outcome in COVID-19 // J Nephrology. 2021. Vol. 34, N 4. P. 991–998. doi: 10.1007/s40620-021-01036-8
- Berni A., Malandrino D., Parenti G., et al. Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together? // J Endocrinol Invest. 2020. Vol. 43, N 8. P. 1137–1139. doi: 10.1007/s40618-020-01301-w
- Zimmer M.A., Zink A.K., Weißer C.W., et al. Hypernatremia-A manifestation of COVID-19: a case series // Pract. 2020. Vol. 14, N 9. P. e01295. doi: 10.1213/XAA.0000000000001295
- Post A., Dullaart R.P., Bakker S.J. Is low sodium intake a risk factor for severe and fatal COVID-19 infection? // Eur J Intern Med. 2020. N 75. P. 109. doi: 10.1016/j.ejim.2020.04.003
- Gheorghe G., Ilie M., Bungau S., et al. Is there a relationship between COVID-19 and hyponatremia? // Medicina (Kaunas). 2021. Vol. 57, N 1. P. 55. doi: 10.3390/medicina57010055
- Crespi B., Alcock J. Conflicts over calcium and the treatment of COVID-19 // Evol Med Public Health. 2020. Vol. 9, N 1. P. 149–156. doi: 10.1093/emph/eoaa046
- Sun J.K., Zhang W.H., Zou L., et al. Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019 // Aging (Albany NY). 2020. Vol. 12, N 12. P. 11287–11295. doi: 10.18632/aging.103526
- Elham A.S., Azam K., Azam J., et al. Serum vitamin D, calcium, and zinc levels in patients with COVID-19 // Clin Nutr ESPEN. 2021. N 43. P. 276–282. doi: 10.1016/j.clnesp.2021.03.040
- Zhou X., Chen D., Wang L., et al. Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical // Biosci Rep. 2020. Vol. 40, N 12. P. BSR20202690. doi: 10.1042/BSR20202690
- Skalny A.V., Timashev P.S., Aschner M., et al. Serum zinc, copper, and other biometals are associated with COVID-19 severity markers // Metabolites. 2021. Vol. 11, N 4. P. 244. doi: 10.3390/metabo11040244
- Liu J., Han P., Wu J., et al. Prevalence and predictive value of hypocalcemia in severe COVID-19 patients // J Infect Public Health. 2020. Vol. 13, N 9. P. 1224–1228. doi: 10.1016/j.jiph.2020.05.029
- Pal R., Ram S., Zohmangaihi D., et al. High prevalence of hypocalcemia in non-severe COVID-19 patients: a retrospective case-control study // Front Med (Lausanne). 2021. N 7. P. 590805. doi: 10.3389/fmed.2020.590805
- Noori M., Nejadghaderi S.A., Sullman M.J., et al. Epidemiology, prognosis and management of potassium disorders in Covid-19 // Rev Med Virol. 2021. Vol. 32, N 1. P. e2262. doi: 10.1002/rmv.2262
- Nasomsong W., Ungthammakhun C., Phiboonbanakit D., et al. Low serum potassium among patients with COVID-19 in Bangkok, Thailand: Coincidence or clinically relevant? // Trop Doct. 2021. Vol. 51, N 2. P. 212–215. doi: 10.1177/0049475520978174
- Циберкин А.И., Кляус Н.А., Сазонова Ю.В., Семенов А.П. Гипокалиемия у госпитализированных пациентов с пневмонией на фоне COVID-19 // Артериальная гипертензия. 2020. Т. 26, № 4. С. 462–467. doi: 10.18705/1607-419X-2020-26-4-462-467
- Alfano G., Ferrari A., Fontana F., et al. Hypokalemia in patients with COVID-19 // Clin Exp Nephrol. 2021. Vol. 25, N 4. P. 401–409. doi: 10.1007/s10157-020-01996-4
- Chen D., Li X., Song Q., et al. Assessment of hypokalemia and clinical characteristics in patients with coronavirus disease 2019 in Wenzhou, China // JAMA Netw Open. 2020. Vol. 3, N 6. P. e2011122. doi: 10.1001/jamanetworkopen.2020.11122
- Moreno-Pérez O., Leon-Ramirez J.M., Fuertes-Kenneally L., et al. Hypokalemia as a sensitive biomarker of disease severity and the requirement for invasive mechanical ventilation requirement in COVID-19 pneumonia: a case series of 306 Mediterranean patients // Int J Infect Dis. 2020. N 100. P. 449–454. doi: 10.1016/j.ijid.2020.09.033
- Nakanishi H., Suzuki M., Maeda H., et al. Differential diagnosis of COVID-19: importance of measuring blood lymphocytes, serum electrolytes, and olfactory and taste functions // Tohoku J Exp Med. 2020. Vol. 252, N 2. P. 109–119. doi: 10.1620/tjem.252.109
- Wang Y., Chen L., Wang J., et al. Electrocardiogram analysis of patients with different types of COVID-19 // Ann Noninvasive Electrocardiol. 2020. Vol. 25, N 6. P. e12806. doi: 10.1111/anec.12806
- Silhol F., Sarlon G., Deharo J.C., Vaïsse B. Downregulation of ACE2 induces overstimulation of the renin-angiotensin system in COVID-19: should we block the renin-angiotensin system? // Hypertens Res. 2020. Vol. 43, N 8. P. 854–856. doi: 10.1038/s41440-020-0476-3
- Di Nicolantonio J.J., O’Keefe J.H. Magnesium and vitamin D deficiency as a potential cause of immune dysfunction, cytokine storm and disseminated intravascular coagulation in COVID-19 patients // Mo Med. 2021. Vol. 118, N 1. P. 68–73.
- Story M.J. Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer // Biochimie. 2021. N 187. P. 94–109. doi: 10.1016/j.biochi.2021.05.013
- Micke O., Vormann J., Kisters K. Magnesium and COVID-19 ― some further comments ― a commentary on wallace tc. combating COVID-19 and building immune resilience: a potential role for magnesium nutrition? // J Am Coll Nutr. 2021. Vol. 40, N 8. P. 732–734. doi: 10.1080/07315724.2020.1816230
- Zeng H.L., Yang Q., Yuan P., et al. Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID-19 // FASEB J. 2021. Vol. 35, N 3. P. e21392. doi: 10.1096/fj.202002346RR
- Quilliot D., Bonsack O., Jaussaud R., Mazur A. Dysmagnesemia in COVID-19 cohort patients: prevalence and associated factors // Magnes Res. 2020. Vol. 33, N 4. P. 114–122. doi: 10.1684/mrh.2021.0476
- Van Kempen T.A., Deixler E. SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19 // Am J Physiol Endocrinol Metab. 2021. Vol. 320, N 1. P. E2–E6. doi: 10.1152/ajpendo.00474.2020
- Iotti S., Wolf F., Mazur A., Maier J.A. The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives // Magnes Res. 2020. Vol. 33, N 2. P. 21–27. doi: 10.1684/mrh.2020.0465
- Sankova M.V., Kytko O.V., Meylanova R.D., et al. Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic // Research Results in Pharmacology. 2020. Vol. 6, N 4. P. 65–76. doi: 10.3897/rrpharmacology6.59407
- Тарасов Е.А., Блинов Д.В., Зимовина У.В., Сандакова Е.А. Дефицит магния и стресс: вопросы взаимосвязи, тесты для диагностики и подходы к терапии // Терапевтический архив. 2015. Т. 87, № 9. C. 114–122. doi: 10.17116/terarkh2015879114-122
- Jose J., Magoon R., Kapoor P.M. Magnesium: the neglected cation in COVID-19? // J Anaesthesiol Clin Pharmacol. 2021. Vol. 37, N 1. P. 141–142. doi: 10.4103/joacp.JOACP_628_20