Study of the effectiveness of the combined method of acne therapy with the use of rf-microneedles and acne monotherapy with isotretinoin in standard doses

Acne is one of the most common diseases of the sebaceous glands and hair follicles. Given the diversity of clinical forms of acne, the choice of therapy must take into account all the peculiarities of the pathological process, as well as gender, age, emotional state of the patient, comorbidities and the degree of compliance of the patient. There were 65 patients diagnosed with acne under observation. To study the morphofunctional features of the skin of patients with acne and their cytokine profile, all patients were divided into 2 groups. Group 1 patients (n = 33) were treated with low-dose combination therapy with isotretinoin followed by RF-microneedles.group 2 patients (n = 32) were treated with standard doses of isotretinoin. All patients underwent the investigation of qualitative characteristics of the skin with the help of salumerie, corneometry, pH-metry. Also, all patients had a blood sample (serum) to determine the concentration of Pro-inflammatory cytokines.

The effectiveness was assessed using the GSS dermatology index (Global Severity Ssore), the modified IgA scale (Investigator’s Global Assessment), the high-valide quality of life index DIKJ, and APSEA (Assessment of the Psychological and Social Effects of Acne). The combined assessment, taking into account clinical research methods with a sufficient degree of confidence, revealed the advantages of a combined method of moderate acne therapy with the use of low doses of isotretinoin and RF-microneedles in comparison with isotretinoin monotherapy at standard dosages.