Variations in the concentration of proinflammatory cytokines under the influence of the combined treatment with the use of barolaserotherapy in the patients of advanced age presenting with knee joint osteoarthrosis


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Abstract

Proinflammatory cytokines are known to play an important role in the development of the inflammatory process in the joints and thereby determine both the clinical picture of a given disease and the choice of the therapeutic strategy for its treatment. We have assessed the cytokine-related status in 100 patients of advanced age presenting with knee joint osteoarthrosis depending on the mode of treatment. The results of the study confirmed the positive effect of medicamental therapy with meloxicam and theraflex carried out during 10 weeks on the level of proinflammatory cytokines that was especially well apparent in the patients presenting with stage I and II of the disease. The combined treatment with the above medications and barolaserotherapy made it possible to significantly improve the cytokine status not only in the patients with stages I and II but also with stage III of the disease probably by virtue of the additional activation of the anti-inflammatory cytokine system.

About the authors

V. V Kir’yanova

State budgetary educational institution of higher professional education “I.I. Mechnikov North-Western State Medical University”, Russian Ministry of Health

ul. Kirochnaya, 41, Sankt-Peterburg, Russia, 191015

Aleksandr P. Patrukhin

State budgetary health facility “City Geriatric Medico-Social Centre”

Email: apatr@mail.ru
Sankt-Peterburg, Russia, 190103

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