The application of neuroprotective preparations for the rehabili-33 tative treatment of the patients presenting with diabetic retinopathy

The objective of the present study was to estimate the effectiveness of the application of neuroprotective and antioxidative preparation semax for the rehabilitative treatment of the patients presenting with non-proliferative diabetic retinopathy. The study included 14 patients (228 eyes) at the age between 42 and 70 years with non-proliferative diabetic retinopathy that developed as a complicvation of type 2 diabetes mellitus. They were divided into 3 groups depending on the therapeutic modality. In the main group, standard therapy was supplemented by endonasal electrophoresis of 0.1% semax. The patients of the reference group were treated by intranasal instillation of semax. Control patients were given standard therapy alone (doxi-chem). The treatment of the patients of the main study and reference groups resulted in significant positive dynamics of the functional parameters being measured (by visometric, perimetric, and electrophysiological techniques). These changes in the main study group were more pronounced and persisted longer (up to 12 months) than in the two others. The results of the study give reason to recommend the method of endonasal electrophoresis of semax for the combined rehabilitative treatment of the patients with diabetes mellitus and early stages of non-proliferative diabetic retinopathy.

non-proliferative diabetic retinopathy, neuroprotectors, endonasal electrophoresis