THE USE OF PHOTOTHERAPY FOR THE CORRECTION OF OXIDATIVE STRESS ASSOCIATED WITH EXPERIMENTAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE

In order to study the status of oxidant and antioxidant systems, as well as the phospholipid spectrum of erythrocytes in the course of phototherapy with the use of ceramic-coated light bulbs, we performed the analysis of blood obtained from the laboratory rats with experimentally induced chronic obstructive pulmonary disease (COPD). It was demonstrated that the rats with experimental COPD underwent intensification of the free-radical oxidation processes in conjunction with the changes of the phospholipid profile. Moreover, the total number of phospholipids was altered (decreased) whereas the amount of lysoforms and free fatty acids in the membranes of red blood cells increased. It is concluded that phototherapy with the use of ceramic-coated light bulbs improves the above characteristics in comparison with those of animals presenting with experimental chronic obstructive pulmonary disease that did not receive such treatment.

oxidative stress, phospholipids, phototherapy, chronic obstructive pulmonary disease, red blood cells