Rationale for the use of a fifth-generation multisymbiotic in medical rehabilitation of patients with post-acute COVID-19 syndrome

Irina N. Smirnova; Смирнова Ирина Николаевна; Irina N. Smirnova; Natalia M. Yurieva; Юрьева Наталия Михайловна; Natalia M. Yurieva; Tatiana N. Zaripova; Зарипова Татьяна Николаевна; Tatiana N. Zaripova; Inna I. Antipova; Антипова Инна Ивановна; Inna I. Antipova; Elena V. Titskaya; Тицкая Елена Васильевна; Elena V. Titskaya; Alexey A. Zaytsev; Зайцев Алексей Александрович; Alexey A. Zaytsev; Oleg V. Sorokin; Cорокин Олег Викторович; Oleg V. Sorokin; Alexey V. Molokeev; Молокеев Алексей Владимирович; Alexey V. Molokeev

doi:10.17816/rjpbr692686

Rationale for the use of a fifth-generation multisymbiotic in medical rehabilitation of patients with post-acute COVID-19 syndrome

Authors: Smirnova I.N.¹, Yurieva N.M.¹, Zaripova T.N.¹, Antipova I.I.¹, Titskaya E.V.¹, Zaytsev A.A.¹, Sorokin O.V.², Molokeev A.V.³
Affiliations:
1. Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology
2. VedaGenetics
3. Vector-BiAlgam
Issue: Vol 24, No 6 (2025)
Pages: 509-518
Section: Original studies
URL: https://journals.rcsi.science/1681-3456/article/view/364048
DOI: https://doi.org/10.17816/rjpbr692686
EDN: https://elibrary.ru/CDNWLN
ID: 364048

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Abstract

BACKGROUND: Post-acute COVID-19 syndrome poses a major healthcare challenge, affecting 20–55% of COVID-19 convalescents. Persistent post-infectious dysfunction of multiple organ systems has demonstrated strong association with gut dysbiosis, which results both from the direct cytopathic effects of the virus and from the iatrogenic pharmacotherapy impact on the gut microbiota. Therefore, the use of probiotics to modulate the composition and function of the gut microbiota may be an important component of rehabilitation, aimed at minimizing disease severity and accelerating the regression of clinical manifestations.

AIM: To establish the clinical and laboratory rationale for incorporating the fifth-generation multisymbiotic VedaBiotic into comprehensive medical rehabilitation for patients with post-acute COVID-19 syndrome.

METHODS: This was a clinical, open-label, prospective, comparative randomized controlled study, involving 128 patients with post-acute COVID-19 syndrome. The rehabilitation program for patients in the control group (group I, n = 64) included therapeutic exercise, classic manual thoracic massage, dry carbon dioxide baths, pulsed electrostatic therapy to the chest using the Hivamat device, and biofeedback (BFB)-assisted respiratory training, performed as 9 daily sessions. Patients in the main group (group II, n = 32) additionally received oral fifth-generation multisymbiotic VedaBiotic, 2 capsules once daily after breakfast. Medical rehabilitation efficacy was assessed by changes in clinical symptoms and relevant laboratory inflammatory markers.

RESULTS: The study demonstrated that adding an oral fifth-generation multisymbiotic into the rehabilitation program results in a pronounced anti-inflammatory and antithrombotic effect, optimizes lipid peroxidation and antioxidant defense systems, and ensures a significant regression of clinical manifestations.

CONCLUSIONS: The developed and scientifically substantiated rehabilitation technology for individuals with post-acute COVID-19 syndrome has demonstrated high safety and efficacy. Its future application could extend beyond this specific syndrome to other acute infections that can induce post-infectious dysfunction of various organ systems.