Medical rehabilitation of complications after injections of lipolytics

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Lipolytic injections are widely used in cosmetology practice. In most cases, they are used to correct the contours of the body, as well as to reduce the amount of fat deposits in the submental area. Side effects after their use are rare and, as a rule, resolve themselves. However, in the case of the use of non-certified medications, the frequency and severity of complications increase sharply, which requires timely and highly qualified therapy.

The article presents overview data concerning the mechanism of action of the main types of lipolytics and their classification, indications and contraindications to lipolytic therapy, reveals the problems of complications that have developed as a result of their use. A description of a clinical case of the development of an inflammatory reaction after injection of a low-quality lipolytic in the area of paint fat bags is presented. The tactics of her therapy are described. This clinical case demonstrates the importance of using certified products, compliance with injection techniques and the correct choice of the patient for this method of cosmetic therapy.

The article is of interest to a wide range of specialists (cosmetologists, dermatovenerologists, plastic surgeons, physiotherapists).

About the authors

Evgeniya V. Ikonnikova

Central State Medical Academy of Department of Presidential Affairs; Institute of Plastic Surgery and Cosmetology

Author for correspondence.
Email: evikonnikova@bk.ru
ORCID iD: 0000-0002-8813-9132
SPIN-code: 9210-8396

MD, Cand. Sci. (Med.)

Russian Federation, Moscow; Moscow

Natalia E. Manturova

Institute of Plastic Surgery and Cosmetology; The Russian National Research Medical University named after N.I. Pirogov

Email: manturovanatalia@bk.ru
ORCID iD: 0000-0003-4281-1947
SPIN-code: 5232-0412

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Larisa S. Kruglova

Central State Medical Academy of Department of Presidential Affairs; Institute of Plastic Surgery and Cosmetology

Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265
SPIN-code: 1107-4372

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

References

  1. Duncan DI, Palmer M. Fat reduction using phosphatidylcholine/sodium deoxycholate injections: Standard of practice. Aesthetic Plast Surg. 2008;32(6):858–872. doi: 10.1007/s00266-008-9188-9
  2. Shirshakova MA. Mesotherapeutic correction of edematous-fibrous panniculopathy (cellulite) and local fat deposits. Plastic Sur Cosmetology. 2010;(3):445–449. (In Russ).
  3. Shirshakova MA. Mesotherapy of cellulite: some practical recommendations. Injection Methods Cosmetology. 2011;(2):26–29. (In Russ).
  4. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: Historical clarification and review. Dermatol Surg. 2006;32(4):465–480. doi: 10.1111/j.1524-4725.2006.32100
  5. Lijnen P, Echevaria-Vazquez D, Petrov V. Influence of cholesterol-lowering on plasma membrane lipids and function. Methods Find Exp Clin Pharmacol. 1996;18(2):123–136.
  6. Lieber CS, Robins SJ, Li J, et al. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology. 1994;106(1):152–159. doi: 10.1016/s0016-5085(94)95023-7
  7. Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo-controlled trial of high-dose lecithin in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 1985;48(8):736–742. doi: 10.1136/jnnp.48.8.736
  8. Cohen BM, Lipinski JF, Altesman RI. Lecithin in the treatment of mania: Double-blind, placebo-controlled trials. Am J Psychiatry. 1982;139(9):1162–1164. doi: 10.1176/ajp.139.9.1162
  9. Bobkova VI, Lokshina LI, Korsunskii VN, Tananova GV. Metabolic effect of lipostabil-forte. Kardiologiia. 1989;29(10):57–60.
  10. Rittes PG, Rites C. Treatment of aging neck with Lipostabil Endovena. J Drugs Dermatol 2009;8(10):937–939.
  11. Heinrich KG. Efficacy of injections of phosphatidylcholine into fat deposits: A non-surgical alternative to liposuction in body-contouring. Indian Journal of Plastic Surgery. 2005;38(2):119–122. doi: 10.4103/0970-0358.19779
  12. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol. 2003;2(5):511–518.
  13. Rittes PG. The lipodissolve technique: Clinical experience. Clin Plast Surg 2009;36(2):215–221. doi: 10.1016/j.cps.2008.11.003
  14. Hasengschwandtner F. Injection lipolysis for effective reduction of localized fat in place of minor surgical lipoplasty. Aesthet Surg J 2006;26(2):125–130. doi: 10.1016/j.asj.2006.01.008
  15. Peckitt N. Evidence based practice: phosphatidylcholine. A review of evidence for the mode of action in injection lipolysis. Jeremy Mills Publishing: Yorkshire, UK; 2005. 154 p.
  16. Duncan D, Rotunda AM. Injectable therapies for localized fat loss: State of the art. Clin Plast Surg. 2011;38(3):489–501. doi: 10.1016/j.cps.2011.02.005
  17. Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatol Surg. 2004;30(7):1001–1008. doi: 10.1111/j.1524-4725.2004.30305
  18. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. J Cosmet Dermatol. 2005;4(4):308–313. doi: 10.1111/j.1473-2165.2005.00211
  19. Rose PT, Morgan M. Histological changes associated with mesotherapy for fat dissolution. J Cosmet Laser Ther. 2005;7(1):17–19. doi: 10.1080/14764170510037743
  20. Palumbo P, Melchiorre E, La Torre C, et al. Effects of phosphatidylcholine and sodium deoxycholate on human primary adipocytes and fresh human adipose tissue. Int J Immunopathol Pharmacol. 2010;23(2):481–489. doi: 10.1177/039463201002300210
  21. Duncan D, Rubin JP, Golitz L, et al. Refinement of technique in injection lipolysis based on scientific studies and clinical eva luation. Clin Plast Surg. 2009;36(2):195–209. doi: 10.1016/j.cps.2008.11.001
  22. Salti G, Ghersetich I, Tantussi F, et al. Phosphatidylcholine and sodium deoxycholate in the treatment of localized fat: A double-blind, randomized study. Dermatol Surg. 2008;34(2):60–66; discussion 66. doi: 10.1111/j.1524-4725.2007.34009
  23. Rotunda AM, Ablon G, Kolodney MS. Lipomas treated with subcutaneous deoxycholate injections. J Am Acad Dermatol. 2005;53(6):973–978. doi: 10.1016/j.jaad.2005.07.068
  24. Yagima Odo ME, Cuce LC, Odo LM, Natrielli A. Action of sodium deoxycholate on subcutaneous human tissue: Local and syste mic effects. Dermatol Surg. 2007;33(2):178–188; discussion 88–89. doi: 10.1111/j.1524-4725.2006.33036
  25. American Society for Aesthetic Plastic Surgery [Internet]. National plastic surgery statistics: Cosmetic and reconstruction procedure trends. New York: American Society for Aesthetic Plastic Surgery. Available from: http://www.plasticsurgery.org/public_education/statistical_trends.cf. Accessed: 15.07.2022.
  26. Vedamurthy M. Mesotherapy. Indian J Dermatol Venereol Leprol. 2007;73(1):60–62. doi: 10.4103/0378-6323.30661
  27. Gupta A, Lobocki C, Singh S, et al. Actions and comparative efficacy of phosphatidylcholine formulation and isolated sodium deoxycholate for different cell types. Aesthetic Plast Surg. 2009;33(3):346–352. doi: 10.1007/s00266-008-9301-0
  28. Duncan D, Hasengschwandtner F. Lipodissolve for subcutaneous fat reduction and skin retraction. Aesthetic Surgery Journal. 2005;25(5):530–543. doi: 10.1016/j.asj.2005.07.009
  29. El-Gowelli HM, El Sabaa B, Yosry E, El-Saghir H. Histopatholo gical and ultra-structural characterization of local neuromuscular damage induced by repeated phosphatidylcholine/deoxycholate injection. Exp Toxicol Pathol. 2016;68(1):39–46. doi: 10.1016/j.etp.2015.09.006
  30. Blandford AD, Ansari W, Young JM, et al. Deoxycholic acid and the marginal mandibular nerve: a cadaver study. Aesthetic Plast Surg. 2018;42(5):1394–1398. doi: 10.1007/s00266-018-1164-4
  31. Sorenson E, Chesnut C. Marginal mandibular versus pseudo-marginal mandibular nerve injury with submandibular deoxycholic acid injection. Dermatol Surg. 2018;44(5):733–735. doi: 10.1097/DSS.0000000000001291
  32. Fagien S, Mcchesney P, Subramanian M, et al. Prevention and management of injection-related adverse effects in facial aesthetics: Considerations for ATX-101 (deoxycholic acid injection) treatment. Dermatol Surg. 2016;42(1):300–304. doi: 10.1097/DSS.0000000000000898
  33. Jones DH, Carruthers J, Joseph JH, et al. REFINE-1, a multicenter, randomized, double-blind, placebo-controlled, phase 3 trial with ATX-101, an injectable drug for submental fat reduction. Dermatol Surg. 2016;42(1):38–49. doi: 10.1097/DSS.0000000000000578
  34. Souyoul S, Gioe O, Emerson A, Hoope D. Alopecia after injection of ATX-101 for reduction of submental fat. Сase Reports JAAD Case Rep. 2017;3(3):250–252. doi: 10.1016/j.jdcr.2017.02.021
  35. Metzger KC, Crowley EL, Kadlubowska D, et al. Uncommon adverse effects of deoxycholic acid injection for submental fullness: Beyond the clinical trials. J Cutan Med Surg. 2020;24(6):619–624. doi: 10.1177/1203475420943270
  36. Prantl L, Gehmert S, Brébant V, et al. Lipolytic effects of nano particle sized polyenylphosphatidylcholine on adipose tissue: First promising in vitro and in vivo results. Hoesl Lin Hemorheol Microcirc. 2020;75(2):189–199. doi: 10.3233/CH-190715
  37. Urbani CE. Urticarial reaction to ethylenediamine in aminophylline following mesotherapy. Contact Dermatitis. 1994;31(3):198–199. doi: 10.1111/j.1600-0536.1994.tb01975.x
  38. Vikbjerg AF, Mu H, Xu X. Lipase-catalyzed acyl exchange of soybean phosphatidylcholine in n-Hexane: A critical evaluation of both acyl incorporation and product recovery. Biotechnol Prog. 2005;21(2):397–404. doi: 10.1021/bp049633y
  39. Duncan DI, Chubaty R. Clinical safety data and standards of practice for injection lipolysis: A retrospective study. Aesthet Surg J. 2006;26(5):575–585. doi: 10.1016/j.asj.2006.08.006
  40. Rosina P, Chieregalo C, Miccolis D, D'Onghia FS. Psoriasis and side-effects of mesotherapy. Int J Dermatol. 2001;40(9):581–583. doi: 10.1046/j.1365-4362.2001.01248-3.x
  41. Gokdemir G, Kucukunal A, Sakiz D. Cutaneous granulomatous reaction from mesotherapy. Dermatol Surg. 2009;35(2):291–293. doi: 10.1111/j.1524-4725.2008.01053.x
  42. Davis MD, Wright TI, Shehan JM. A complication of mesotherapy: Noninfectious granulomatous panniculitis. Arch Dermatol. 2008;144(6):808–809. doi: 10.1001/archderm.144.6.808
  43. Tan J, Rao B. Mesotherapy-induced panniculitis treated with dapsone: Case report and review of reported adverse effects of mesotherapy. J Cutan Med Surg. 2006;10(2):92–95. doi: 10.2310/7750.2006.00013
  44. Kutlubay Z, Gokalp H, Ince U, Engin B. Cutaneous foreign body granulomas associated with lipolytic cocktail: Who is the ene my, mesotherapy or drugs injected? J Cosmet Laser Ther. 2017;19(5):310–312. doi: 10.1080/14764172.2017.1303167

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Patient D., 52 years old. Type of injection lipolytic injection area during initial treatment.

Download (28KB)
3. Fig. 2. Patient D., 52 years old. Ultrasound picture of the soft tissues of the face in the area of injection injection during the initial treatment.

Download (26KB)
4. Fig. 3. Patient D., 52 years old. Appearance at the control examination after the end of medication therapy: complete reduction of edema and erythema.

Download (24KB)

Copyright (c) 2022 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies