Modular Nanotransporter with P21 Fragment Inhibits DNA Repair after Bleomycin Treatment

T. R. Kamaletdinova; A. A. Rosenkranz; A. V. Ulasov; Y. V. Khramtsov; A. D. Tsvetkova; G. P. Georgiev; A. S. Sobolev

doi:10.1134/S1607672918020114

Modular Nanotransporter with P21 Fragment Inhibits DNA Repair after Bleomycin Treatment

Autores: Kamaletdinova T.R.¹, Rosenkranz A.A.¹^,2, Ulasov A.V.¹, Khramtsov Y.V.¹, Tsvetkova A.D.¹^,2, Georgiev G.P.¹, Sobolev A.S.¹^,2
Afiliações:
1. Institute of Gene Biology
2. Faculty of Biology
Edição: Volume 479, Nº 1 (2018)
Páginas: 95-97
Seção: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212175
DOI: https://doi.org/10.1134/S1607672918020114
ID: 212175

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Modular nanotransporter (MNT) with C-terminal fragment of the p21 protein was synthesized and characterized, and its effect on DNA lesions was studied. This p21 fragment in MNT can significantly inhibit DNA repair in A431 human carcinoma cells after bleomycin treatment.