Occurrence of 14-hydroxylated taxoids in the plant in vitro cell cultures of different yew species ( Taxus  spp.)

D. V. Kochkin; E. B. Globa; E. V. Demidova; V. V. Gaisinsky; B. A. Galishev; N. G. Kolotyrkina; Vl. V. Kuznetsov; A. M. Nosov

doi:10.1134/S1607672917050131

Occurrence of 14-hydroxylated taxoids in the plant in vitro cell cultures of different yew species (Taxus spp.)

Authors: Kochkin D.V.¹^,2, Globa E.B.², Demidova E.V.², Gaisinsky V.V.², Galishev B.A.³, Kolotyrkina N.G.⁴, Kuznetsov V.V.², Nosov A.M.¹^,2
Affiliations:
1. Faculty of Biology
2. Timiryazev Institute of Plant Physiology
3. Yeltsin Ural Federal University
4. Zelinsky Institute of Organic Chemistry
Issue: Vol 476, No 1 (2017)
Pages: 337-339
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211996
DOI: https://doi.org/10.1134/S1607672917050131
ID: 211996

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

This is the first study to show that the formation of 14β-hydroxylated derivatives of taxa-4(20),11-diene is a specific feature of in vitro cultured dedifferentiated yew cells that distinguishes them from intact plant cells. This may be due to a lower toxicity of the 14-OH taxoids for proliferating plant cells compared to the 13-OH derivatives.