Occurrence of 14-hydroxylated taxoids in the plant in vitro cell cultures of different yew species ( Taxus  spp.)

D. V. Kochkin; E. B. Globa; E. V. Demidova; V. V. Gaisinsky; B. A. Galishev; N. G. Kolotyrkina; Vl. V. Kuznetsov; A. M. Nosov

doi:10.1134/S1607672917050131

Occurrence of 14-hydroxylated taxoids in the plant in vitro cell cultures of different yew species (Taxus spp.)

Autores: Kochkin D.V.¹^,2, Globa E.B.², Demidova E.V.², Gaisinsky V.V.², Galishev B.A.³, Kolotyrkina N.G.⁴, Kuznetsov V.V.², Nosov A.M.¹^,2
Afiliações:
1. Faculty of Biology
2. Timiryazev Institute of Plant Physiology
3. Yeltsin Ural Federal University
4. Zelinsky Institute of Organic Chemistry
Edição: Volume 476, Nº 1 (2017)
Páginas: 337-339
Seção: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211996
DOI: https://doi.org/10.1134/S1607672917050131
ID: 211996

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This is the first study to show that the formation of 14β-hydroxylated derivatives of taxa-4(20),11-diene is a specific feature of in vitro cultured dedifferentiated yew cells that distinguishes them from intact plant cells. This may be due to a lower toxicity of the 14-OH taxoids for proliferating plant cells compared to the 13-OH derivatives.